CYP3A7 | ENSG00000160870 | NCBI 1551

Details for: CYP3A7

Gene ID: 1551

Symbol: CYP3A7

Ensembl ID: ENSG00000160870

Description: cytochrome P450 family 3 subfamily A member 7

Associated with

Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
All-trans retinoic acid 18-hydroxylase activity
(GO:0062183)
Aromatase activity
(GO:0070330)
Endoplasmic reticulum membrane
(GO:0005789)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Monooxygenase activity
(GO:0004497)
Oxidative demethylation
(GO:0070989)
Oxygen binding
(GO:0019825)
Retinoic acid 4-hydroxylase activity
(GO:0008401)
Retinoic acid metabolic process
(GO:0042573)
Retinol metabolic process
(GO:0042572)
Steroid biosynthetic process
(GO:0006694)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Testosterone 6-beta-hydroxylase activity
(GO:0050649)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: plasmablast (CL0000980)
Fold Change: 1.5236
Cell Significance Index: 14.1400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4218
Cell Significance Index: 270.5800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.2377
Cell Significance Index: 29.9800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.0119
Cell Significance Index: 32.4100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9702
Cell Significance Index: 95.9700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8807
Cell Significance Index: 795.2300
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.7882
Cell Significance Index: 11.2200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5759
Cell Significance Index: 114.2900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5427
Cell Significance Index: 7.4100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5077
Cell Significance Index: 82.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4724
Cell Significance Index: 51.3800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.4278
Cell Significance Index: 6.3200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3620
Cell Significance Index: 7.7100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2893
Cell Significance Index: 22.2000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2779
Cell Significance Index: 19.2200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2500
Cell Significance Index: 15.0100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.2309
Cell Significance Index: 3.0200
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.1832
Cell Significance Index: 0.6900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1658
Cell Significance Index: 10.1900
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1082
Cell Significance Index: 1.2900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0953
Cell Significance Index: 19.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0722
Cell Significance Index: 3.7500
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0577
Cell Significance Index: 0.9700
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.0556
Cell Significance Index: 0.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0555
Cell Significance Index: 1.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0538
Cell Significance Index: 19.2900
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0461
Cell Significance Index: 0.6600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0342
Cell Significance Index: 0.8200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0318
Cell Significance Index: 0.6600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0287
Cell Significance Index: 1.2700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0256
Cell Significance Index: 0.9700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0251
Cell Significance Index: 1.2700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0184
Cell Significance Index: 5.3100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0057
Cell Significance Index: 0.2000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0018
Cell Significance Index: 0.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0031
Cell Significance Index: -0.1400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0037
Cell Significance Index: -0.1000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0057
Cell Significance Index: -4.1900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0062
Cell Significance Index: -0.1100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0062
Cell Significance Index: -4.6600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0063
Cell Significance Index: -4.6400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0072
Cell Significance Index: -0.1800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0075
Cell Significance Index: -1.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0080
Cell Significance Index: -4.3600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0087
Cell Significance Index: -4.8900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0156
Cell Significance Index: -1.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0162
Cell Significance Index: -1.9900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0196
Cell Significance Index: -3.3400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0239
Cell Significance Index: -5.0300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0258
Cell Significance Index: -3.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0278
Cell Significance Index: -3.1900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0385
Cell Significance Index: -1.1400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0421
Cell Significance Index: -2.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0429
Cell Significance Index: -2.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0448
Cell Significance Index: -2.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0474
Cell Significance Index: -1.2900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0527
Cell Significance Index: -4.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0544
Cell Significance Index: -3.4300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0587
Cell Significance Index: -1.0200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0730
Cell Significance Index: -1.1000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0749
Cell Significance Index: -3.5200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0857
Cell Significance Index: -3.5100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0901
Cell Significance Index: -1.2900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0931
Cell Significance Index: -1.8200
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0950
Cell Significance Index: -1.3500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0951
Cell Significance Index: -3.3300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0968
Cell Significance Index: -3.1700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1099
Cell Significance Index: -3.5000
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1134
Cell Significance Index: -1.8200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1148
Cell Significance Index: -2.2400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1155
Cell Significance Index: -2.4100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1183
Cell Significance Index: -2.9500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1213
Cell Significance Index: -3.0300
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1259
Cell Significance Index: -2.1700
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.1269
Cell Significance Index: -1.5100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1351
Cell Significance Index: -4.9600
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.1413
Cell Significance Index: -1.9600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1428
Cell Significance Index: -3.0300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1438
Cell Significance Index: -3.8400
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1490
Cell Significance Index: -1.8800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1500
Cell Significance Index: -3.2400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1552
Cell Significance Index: -4.4500
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.1617
Cell Significance Index: -2.3000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1636
Cell Significance Index: -2.0400
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1658
Cell Significance Index: -2.2700
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.1662
Cell Significance Index: -1.7800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1676
Cell Significance Index: -3.3700
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.1721
Cell Significance Index: -2.5800
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.1723
Cell Significance Index: -1.6800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1750
Cell Significance Index: -3.4600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1794
Cell Significance Index: -4.5700
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1858
Cell Significance Index: -3.7800
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.1878
Cell Significance Index: -2.1300
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1927
Cell Significance Index: -4.2200
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1948
Cell Significance Index: -2.0200
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1951
Cell Significance Index: -3.8400
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.1970
Cell Significance Index: -2.1500
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1983
Cell Significance Index: -2.0700
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2016
Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** CYP3A7 is a monooxygenase enzyme that exhibits a high degree of substrate specificity, primarily targeting steroids, retinoids, and xenobiotics. Its expression is tightly regulated by various factors, including transcriptional control and post-translational modifications. CYP3A7 has a distinct molecular structure, featuring a heme-binding domain and a cytochrome P450 reductase (POR) interaction site. This unique structure enables the enzyme to efficiently catalyze oxidative reactions. **Pathways and Functions:** CYP3A7 is involved in a wide range of metabolic pathways, including: 1. **Steroid biosynthesis and metabolism:** CYP3A7 plays a critical role in the hydroxylation of steroids, such as testosterone and estrogen, which are essential for various physiological processes. 2. **Retinoid metabolism:** This enzyme is involved in the hydroxylation of retinoids, including all-trans retinoic acid, which is crucial for cell differentiation and development. 3. **Xenobiotic metabolism:** CYP3A7 is responsible for the metabolism of xenobiotics, including drugs and environmental toxins, which helps to detoxify these substances. 4. **Endoplasmic reticulum membrane:** CYP3A7 is embedded in the endoplasmic reticulum membrane, where it interacts with other enzymes and proteins to facilitate metabolic reactions. **Clinical Significance:** CYP3A7 has significant implications in various clinical contexts, including: 1. **Pharmacokinetics and pharmacodynamics:** Variations in CYP3A7 expression and activity can affect the metabolism and efficacy of drugs, such as statins and antipsychotics. 2. **Cancer therapy:** CYP3A7 is involved in the metabolism of certain chemotherapeutic agents, which can influence treatment outcomes. 3. **Retinoid therapy:** Abnormalities in CYP3A7 expression can impact the efficacy and safety of retinoid-based treatments for conditions such as acne and psoriasis. 4. **Endocrine disorders:** CYP3A7 is involved in the regulation of steroid metabolism, which can contribute to the development of endocrine disorders, such as polycystic ovary syndrome (PCOS). In conclusion, CYP3A7 is a multifaceted enzyme that plays a crucial role in various metabolic pathways. Its clinical significance extends to pharmacokinetics, cancer therapy, retinoid therapy, and endocrine disorders. Further research is needed to fully elucidate the mechanisms and implications of CYP3A7 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.