Genular: Defining Cellular Identity and Function

Details for: Hspd1

Gene ID: 15510

Symbol: Hspd1

Ensembl ID: ENSMUSG00000025980

Description: heat shock protein 1 (chaperonin)

Associated with

Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Mitochondrial protein import
(R-MMU-1268020)
Protein localization
(R-MMU-9609507)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adhesion of symbiont to host
(GO:0044406)
Apolipoprotein a-i binding
(GO:0034186)
Apolipoprotein binding
(GO:0034185)
Apoptotic mitochondrial changes
(GO:0008637)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
B cell activation
(GO:0042113)
B cell proliferation
(GO:0042100)
Biological process involved in interaction with symbiont
(GO:0051702)
Cell surface
(GO:0009986)
Cellular response to interleukin-7
(GO:0098761)
Clathrin-coated pit
(GO:0005905)
Coated vesicle
(GO:0030135)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Double-stranded rna binding
(GO:0003725)
Early endosome
(GO:0005769)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Golgi cisterna
(GO:0031985)
High-density lipoprotein particle binding
(GO:0008035)
Interferon-alpha production
(GO:0032607)
Intracellular membrane-bounded organelle
(GO:0043231)
Isomerase activity
(GO:0016853)
Isotype switching to igg isotypes
(GO:0048291)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide receptor complex
(GO:0046696)
Membrane
(GO:0016020)
Migrasome
(GO:0140494)
Mitochondrial crista
(GO:0030061)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial unfolded protein response
(GO:0034514)
Mitochondrion
(GO:0005739)
Modification-dependent protein binding
(GO:0140030)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Myelin sheath
(GO:0043209)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of apoptotic process in bone marrow cell
(GO:0071866)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Nucleotide binding
(GO:0000166)
P53 binding
(GO:0002039)
Peroxisomal matrix
(GO:0005782)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell mediated immune response to tumor cell
(GO:0002842)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein folding
(GO:0006457)
Protein import into mitochondrial intermembrane space
(GO:0045041)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Response to unfolded protein
(GO:0006986)
Secretory granule
(GO:0030141)
Sperm midpiece
(GO:0097225)
Sperm plasma membrane
(GO:0097524)
T cell activation
(GO:0042110)
Type ii interferon production
(GO:0032609)
Ubiquitin protein ligase binding
(GO:0031625)
Zymogen granule
(GO:0042588)

Other Information

Proteins

60 kDa heat shock protein, mitochondrial

Genular Protein ID: 2360959971

Symbol: CH60_MOUSE

Name: 60 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P63038 P19226 P19227 P97602 Q3KQP2 Q3UIP0 Q8C2C7 Q8VEF4

Database IDs:

Citations:

PubMed ID: 2263486

Title: Nucleotide and deduced amino acid sequence of a murine cDNA clone encoding one member of the hsp65 multigene family.

PubMed ID: 2263486

DOI: 10.1093/nar/18.23.7153

PubMed ID: 1347942

Title: An interaction between p21ras and heat shock protein hsp60, a chaperonin.

PubMed ID: 1347942

DOI: 10.1073/pnas.89.6.2012

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1979012

Title: Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA.

PubMed ID: 1979012

DOI: 10.1016/0167-4781(90)90008-p

PubMed ID: 7523108

Title: Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.

PubMed ID: 7523108

DOI: 10.1002/elps.11501501101

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 573
Mass: 60955
Checksum: 0014B58B77D0127B
Sequence:

MLRLPTVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR 
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA 
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK 
DIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ 
DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV 
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQAH DLGKVGEVIV TKDDAMLLKG 
KGDKAHIEKR IQEITEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR 
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLKPANED QKIGIEIIKR ALKIPAMTIA 
KNAGVEGSLI VEKILQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT 
TAEAVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspd1

Associated with

Other Information

Nucleotide and deduced amino acid sequence of a murine cDNA clone encoding one member of the hsp65 multigene family. PubMed ID: 2263486

An interaction between p21ras and heat shock protein hsp60, a chaperonin. PubMed ID: 1347942

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA. PubMed ID: 1979012

Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. PubMed ID: 7523108

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753