Genular: Defining Cellular Identity and Function

Details for: Hspa2

Gene ID: 15512

Symbol: Hspa2

Ensembl ID: ENSMUSG00000059970

Description: heat shock protein 2

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Attenuation phase
(R-MMU-3371568)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Cytokine signaling in immune system
(R-MMU-1280215)
Hsf1-dependent transactivation
(R-MMU-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Pkr-mediated signaling
(R-MMU-9833482)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Catsper complex
(GO:0036128)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Enzyme binding
(GO:0019899)
Glycolipid binding
(GO:0051861)
Heat shock protein binding
(GO:0031072)
Male germ cell nucleus
(GO:0001673)
Male meiosis i
(GO:0007141)
Male meiotic nuclear division
(GO:0007140)
Meiotic spindle
(GO:0072687)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Negative regulation of inclusion body assembly
(GO:0090084)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of atp-dependent activity
(GO:0032781)
Positive regulation of atpase-coupled calcium transmembrane transporter activity
(GO:1901896)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
Synaptonemal complex
(GO:0000795)
Synaptonemal complex disassembly
(GO:0070194)
Tau protein binding
(GO:0048156)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Heat shock-related 70 kDa protein 2

Genular Protein ID: 3305435165

Symbol: HSP72_MOUSE

Name: Heat shock-related 70 kDa protein 2

UniProtKB Accession Codes:

P17156 Q99KD7

Database IDs:

Citations:

PubMed ID: 3405224

Title: Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line.

PubMed ID: 3405224

DOI: 10.1128/mcb.8.7.2925-2932.1988

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18849567

Title: A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.

PubMed ID: 18849567

DOI: 10.1074/jbc.m805590200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20547853

Title: MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.

PubMed ID: 20547853

DOI: 10.1073/pnas.1007158107

PubMed ID: 21224844

Title: A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.

PubMed ID: 21224844

DOI: 10.1038/ncomms1153

PubMed ID: 23055941

Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

PubMed ID: 23055941

DOI: 10.1371/journal.pgen.1002969

PubMed ID: 24557841

Title: SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis.

PubMed ID: 24557841

DOI: 10.1093/molehr/gau014

Sequence Information:

Length: 633
Mass: 69642
Checksum: 6F65773C7EFFA69F
Sequence:

MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV 
AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG EMKTFFPEEI 
SSMVLTKMKE IAEAYLGGKV QSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA 
AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM 
VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI 
TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK 
ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN 
TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT 
FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA 
AKNAVESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK 
ELERVCNPII SKLYQGGPGG GGSSGGPTIE EVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspa2

Associated with

Other Information

Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. PubMed ID: 3405224

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. PubMed ID: 18849567

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. PubMed ID: 20547853

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. PubMed ID: 21224844

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PubMed ID: 23055941

SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. PubMed ID: 24557841