Genular: Defining Cellular Identity and Function

Details for: Hsp90ab1

Gene ID: 15516

Symbol: Hsp90ab1

Ensembl ID: ENSMUSG00000023944

Description: heat shock protein 90 alpha (cytosolic), class B member 1

Associated with

Aryl hydrocarbon receptor signalling
(R-MMU-8937144)
Attenuation phase
(R-MMU-3371568)
Axon guidance
(R-MMU-422475)
Biological oxidations
(R-MMU-211859)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Developmental biology
(R-MMU-1266738)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G2/m transition
(R-MMU-69275)
Hsf1 activation
(R-MMU-3371511)
Hsf1-dependent transactivation
(R-MMU-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Inflammasomes
(R-MMU-622312)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Mitotic g2-g2/m phases
(R-MMU-453274)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Phase i - functionalization of compounds
(R-MMU-211945)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rhobtb2 gtpase cycle
(R-MMU-9013418)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Sema3a pak dependent axon repulsion
(R-MMU-399954)
Semaphorin interactions
(R-MMU-373755)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The nlrp3 inflammasome
(R-MMU-844456)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Atp-dependent protein binding
(GO:0043008)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell surface
(GO:0009986)
Cellular response to heat
(GO:0034605)
Cellular response to interleukin-4
(GO:0071353)
Cop9 signalosome
(GO:0008180)
Ctp binding
(GO:0002135)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Datp binding
(GO:0032564)
Disordered domain specific binding
(GO:0097718)
Dna polymerase binding
(GO:0070182)
Double-stranded rna binding
(GO:0003725)
Extracellular region
(GO:0005576)
Gtp binding
(GO:0005525)
Heat shock protein binding
(GO:0031072)
Heterocyclic compound binding
(GO:1901363)
Histone deacetylase binding
(GO:0042826)
Histone methyltransferase binding
(GO:1990226)
Identical protein binding
(GO:0042802)
Intracellular anatomical structure
(GO:0005622)
Kinase binding
(GO:0019900)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of complement-dependent cytotoxicity
(GO:1903660)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of proteasomal protein catabolic process
(GO:1901799)
Negative regulation of protein metabolic process
(GO:0051248)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptide binding
(GO:0042277)
Placenta development
(GO:0001890)
Plasma membrane
(GO:0005886)
Positive regulation of cell size
(GO:0045793)
Positive regulation of cyclin-dependent protein kinase activity
(GO:1904031)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein kinase regulator activity
(GO:0019887)
Protein stabilization
(GO:0050821)
Regulation of protein localization
(GO:0032880)
Response to organic substance
(GO:0010033)
Sulfonylurea receptor binding
(GO:0017098)
Tau protein binding
(GO:0048156)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Utp binding
(GO:0002134)

Other Information

Proteins

Heat shock protein HSP 90-beta

Genular Protein ID: 281421588

Symbol: HS90B_MOUSE

Name: Heat shock protein HSP 90-beta

UniProtKB Accession Codes:

P11499 O89078 Q3UIQ7

Database IDs:

Citations:

PubMed ID: 2469626

Title: Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.

PubMed ID: 2469626

DOI: 10.1016/0378-1119(88)90182-5

PubMed ID: 2445630

Title: Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences.

PubMed ID: 2445630

DOI: 10.1016/0378-1119(87)90155-7

PubMed ID: 2925609

Title: Murine 86- and 84-kDa heat shock proteins, cDNA sequences, chromosome assignments, and evolutionary origins.

PubMed ID: 2925609

DOI: 10.1016/s0021-9258(18)83551-7

PubMed ID: 1976316

Title: Characterization of the mouse 84-kD heat shock protein gene family.

PubMed ID: 1976316

DOI: 10.1089/dna.1990.9.387

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 3458168

Title: A mouse tumor-specific transplantation antigen is a heat shock-related protein.

PubMed ID: 3458168

DOI: 10.1073/pnas.83.10.3121

PubMed ID: 8289821

Title: The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.

PubMed ID: 8289821

DOI: 10.1128/mcb.14.2.1459-1464.1994

PubMed ID: 9798653

Title: Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.

PubMed ID: 9798653

DOI: 10.1016/s0161-5890(98)00031-5

PubMed ID: 1406681

Title: Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

PubMed ID: 1406681

DOI: 10.1128/mcb.12.11.5059-5068.1992

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 15642353

Title: Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein.

PubMed ID: 15642353

DOI: 10.1016/j.febslet.2004.12.005

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17622165

Title: A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.

PubMed ID: 17622165

DOI: 10.1021/pr070122r

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21689689

Title: TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells.

PubMed ID: 21689689

DOI: 10.1016/j.bbamcr.2011.05.013

PubMed ID: 22556278

Title: Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.

PubMed ID: 22556278

DOI: 10.1074/mcp.m111.015966

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 27686098

Title: REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor.

PubMed ID: 27686098

DOI: 10.1242/jcs.190959

PubMed ID: 27496612

Title: Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.

PubMed ID: 27496612

DOI: 10.1002/jcb.25669

Sequence Information:

Length: 724
Mass: 83281
Checksum: CE323E81CE173ECB
Sequence:

MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK 
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE 
DKEDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV 
FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA 
EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ 
KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG 
LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA 
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE 
TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVTAEEP SAAVPDEIPP LEGDEDASRM 
EEVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hsp90ab1

Associated with

Other Information

Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens. PubMed ID: 2469626

Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences. PubMed ID: 2445630

Murine 86- and 84-kDa heat shock proteins, cDNA sequences, chromosome assignments, and evolutionary origins. PubMed ID: 2925609

Characterization of the mouse 84-kD heat shock protein gene family. PubMed ID: 1976316

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A mouse tumor-specific transplantation antigen is a heat shock-related protein. PubMed ID: 3458168

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo. PubMed ID: 8289821

Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. PubMed ID: 9798653

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84). PubMed ID: 1406681

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. PubMed ID: 15642353

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. PubMed ID: 17622165

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells. PubMed ID: 21689689

Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag. PubMed ID: 22556278

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor. PubMed ID: 27686098

Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90. PubMed ID: 27496612