Genular: Defining Cellular Identity and Function

Details for: Hspa9

Gene ID: 15526

Symbol: Hspa9

Ensembl ID: ENSMUSG00000024359

Description: heat shock protein 9

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cytoplasm
(GO:0005737)
Enzyme binding
(GO:0019899)
Erythrocyte differentiation
(GO:0030218)
Fibroblast growth factor binding
(GO:0017134)
Heat shock protein binding
(GO:0031072)
Iron-sulfur cluster assembly
(GO:0016226)
Mitochondrial matrix
(GO:0005759)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of hematopoietic stem cell differentiation
(GO:1902037)
Negative regulation of hemopoiesis
(GO:1903707)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Regulation of erythrocyte differentiation
(GO:0045646)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

75 kDa glucose-regulated protein

Genular Protein ID: 2415900329

Symbol: GRP75_MOUSE

Name: 75 kDa glucose-regulated protein

UniProtKB Accession Codes:

P38647 Q3TW93 Q3UVN1 Q3V015 Q7TSZ0 Q9CQ05

Database IDs:

Citations:

PubMed ID: 8454632

Title: Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype.

PubMed ID: 8454632

DOI: 10.1016/s0021-9258(18)53295-6

PubMed ID: 7693662

Title: Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells.

PubMed ID: 7693662

DOI: 10.1016/s0021-9258(18)41515-3

PubMed ID: 7684501

Title: Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.

PubMed ID: 7684501

DOI: 10.1128/mcb.13.6.3598-3610.1993

PubMed ID: 8262211

Title: Structure and organization of the gene encoding a mouse mitochondrial stress-70 protein.

PubMed ID: 8262211

DOI: 10.1016/0014-5793(93)81602-v

PubMed ID: 7692847

Title: Antigenic protein specific for C3H strain mouse is a mitochondrial stress-70 protein.

PubMed ID: 7692847

DOI: 10.1006/bbrc.1993.2238

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7523108

Title: Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.

PubMed ID: 7523108

DOI: 10.1002/elps.11501501101

PubMed ID: 7865888

Title: PBP74, a new member of the mammalian 70-kDa heat shock protein family, is a mitochondrial protein.

PubMed ID: 7865888

DOI: 10.1091/mbc.5.11.1265

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21123823

Title: Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

PubMed ID: 21123823

DOI: 10.1182/blood-2010-06-293167

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 26702583

Title: Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.

PubMed ID: 26702583

DOI: 10.1016/j.mito.2015.12.005

Sequence Information:

Length: 679
Mass: 73461
Checksum: DF1C997775627928
Sequence:

MISASRAAAA RLVGTAASRS PAAARPQDGW NGLSHEAFRF VSRRDYASEA IKGAVVGIDL 
GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL VGMPAKRQAV TNPNNTFYAT 
KRLIGRRYDD PEVQKDTKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN 
YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI 
AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK 
DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDASGPK HLNMKLTRAQ FEGIVTDLIK 
RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG 
AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT 
QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG 
REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK 
DQLPADECNK LKEEISKMRA LLAGKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE 
GSGSSGTGEQ KEDQKEEKQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspa9

Associated with

Other Information

Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. PubMed ID: 8454632

Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells. PubMed ID: 7693662

Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. PubMed ID: 7684501

Structure and organization of the gene encoding a mouse mitochondrial stress-70 protein. PubMed ID: 8262211

Antigenic protein specific for C3H strain mouse is a mitochondrial stress-70 protein. PubMed ID: 7692847

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. PubMed ID: 7523108

PBP74, a new member of the mammalian 70-kDa heat shock protein family, is a mitochondrial protein. PubMed ID: 7865888

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice. PubMed ID: 21123823

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. PubMed ID: 26702583