Details for: CYP2A13

Gene ID: 1553

Symbol: CYP2A13

Ensembl ID: ENSG00000197838

Description: cytochrome P450 family 2 subfamily A member 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 4.8753
    Cell Significance Index: 50.2900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.5524
    Cell Significance Index: 5.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1907
    Cell Significance Index: 2.7800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0552
    Cell Significance Index: 0.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0498
    Cell Significance Index: 0.6800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0302
    Cell Significance Index: 0.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0202
    Cell Significance Index: 0.1400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0069
    Cell Significance Index: 0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0082
    Cell Significance Index: -1.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0082
    Cell Significance Index: -1.6200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0104
    Cell Significance Index: -2.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0109
    Cell Significance Index: -3.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0146
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0160
    Cell Significance Index: -1.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0212
    Cell Significance Index: -0.4700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0273
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0283
    Cell Significance Index: -1.9000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0305
    Cell Significance Index: -0.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0307
    Cell Significance Index: -1.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0313
    Cell Significance Index: -0.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0353
    Cell Significance Index: -0.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0371
    Cell Significance Index: -2.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0455
    Cell Significance Index: -1.2200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0519
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0540
    Cell Significance Index: -0.5700
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0555
    Cell Significance Index: -0.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0561
    Cell Significance Index: -3.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0566
    Cell Significance Index: -1.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0579
    Cell Significance Index: -1.8300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0649
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0661
    Cell Significance Index: -0.9100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0676
    Cell Significance Index: -0.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0676
    Cell Significance Index: -2.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0714
    Cell Significance Index: -2.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0718
    Cell Significance Index: -2.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0719
    Cell Significance Index: -1.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0733
    Cell Significance Index: -1.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0743
    Cell Significance Index: -1.0300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0753
    Cell Significance Index: -0.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0782
    Cell Significance Index: -1.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0787
    Cell Significance Index: -2.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0804
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0818
    Cell Significance Index: -2.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0824
    Cell Significance Index: -2.3000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0825
    Cell Significance Index: -0.8800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.0830
    Cell Significance Index: -0.8200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0854
    Cell Significance Index: -0.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0866
    Cell Significance Index: -1.6000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0874
    Cell Significance Index: -0.6800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0878
    Cell Significance Index: -0.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0930
    Cell Significance Index: -2.0100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0934
    Cell Significance Index: -1.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0939
    Cell Significance Index: -1.9600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0947
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0962
    Cell Significance Index: -1.0700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0974
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0975
    Cell Significance Index: -2.8100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0983
    Cell Significance Index: -1.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0997
    Cell Significance Index: -2.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1011
    Cell Significance Index: -1.7000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1025
    Cell Significance Index: -1.2200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1085
    Cell Significance Index: -1.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1098
    Cell Significance Index: -2.3300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1107
    Cell Significance Index: -1.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1113
    Cell Significance Index: -2.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1131
    Cell Significance Index: -2.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1135
    Cell Significance Index: -1.4900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1150
    Cell Significance Index: -1.7500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1155
    Cell Significance Index: -1.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1161
    Cell Significance Index: -2.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1173
    Cell Significance Index: -2.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1174
    Cell Significance Index: -2.0300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1187
    Cell Significance Index: -1.4200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1190
    Cell Significance Index: -1.3600
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1199
    Cell Significance Index: -1.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1210
    Cell Significance Index: -1.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1234
    Cell Significance Index: -2.9900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.1237
    Cell Significance Index: -1.3800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1249
    Cell Significance Index: -1.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1250
    Cell Significance Index: -1.7800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1265
    Cell Significance Index: -1.4700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1271
    Cell Significance Index: -1.2300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1290
    Cell Significance Index: -1.4000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1296
    Cell Significance Index: -1.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Substrate specificity**: CYP2A13 exhibits specificity for arachidonic acid, coumarins, and other compounds, which are metabolized through its monooxygenase activity. 2. **Monooxygenase activity**: The enzyme catalyzes the incorporation of one atom of oxygen into the substrate, resulting in the formation of a hydroxylated product. 3. **Expression in various tissues**: CYP2A13 is expressed in multiple tissues, including the liver, kidneys, intestines, and the central nervous system. 4. **Regulation of metabolic pathways**: The CYP2A13 enzyme is involved in various metabolic pathways, including the aflatoxin activation and detoxification, arachidonic acid epoxygenase activity, and xenobiotic metabolic process. **Pathways and Functions** 1. **Aflatoxin activation and detoxification**: CYP2A13 plays a critical role in the metabolism of aflatoxins, which are toxic compounds produced by certain molds. The enzyme catalyzes the conversion of aflatoxins into less toxic metabolites, thereby protecting the body from their harmful effects. 2. **Arachidonic acid epoxygenase activity**: CYP2A13 is involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid that plays a crucial role in inflammation and immune responses. 3. **Coumarin metabolic process**: The enzyme catalyzes the hydroxylation of coumarins, a group of compounds that are found in various plants and are used as anticoagulants. 4. **Xenobiotic metabolic process**: CYP2A13 is involved in the metabolism of various xenobiotics, including environmental pollutants, drugs, and endogenous compounds. **Clinical Significance** 1. **Cancer risk**: The CYP2A13 enzyme is involved in the metabolism of aflatoxins, which are known to be carcinogenic. Variations in the CYP2A13 gene have been associated with an increased risk of liver cancer. 2. **Neurological disorders**: The enzyme's involvement in the metabolism of arachidonic acid and coumarins suggests that CYP2A13 may play a role in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Drug metabolism**: CYP2A13 is involved in the metabolism of various drugs, including anticoagulants and anti-inflammatory agents. Variations in the CYP2A13 gene may affect the efficacy and toxicity of these medications. 4. **Environmental exposure**: The enzyme's role in the metabolism of xenobiotics highlights the importance of understanding the impact of environmental exposure on human health. CYP2A13 may play a role in the detoxification of environmental pollutants, such as pesticides and heavy metals. In conclusion, the CYP2A13 gene plays a critical role in the metabolism and detoxification of various compounds, including xenobiotics, arachidonic acid, and coumarins. Its involvement in various metabolic pathways and its expression in multiple tissues make it a crucial component of the cytochrome P450 enzyme family. Understanding the functions and clinical significance of CYP2A13 can provide valuable insights into the development of new therapeutic strategies and the prevention of various diseases.

Genular Protein ID: 562174136

Symbol: CP2AD_HUMAN

Name: Cytochrome P450 2A13

UniProtKB Accession Codes:

Q16696 Q53YR8 Q6R569 Q6R570 Q9H2X2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7668294

Title: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

PubMed ID: 7668294

PubMed ID: 11016631

Title: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

PubMed ID: 11016631

PubMed ID: 15063809

Title: Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility.

PubMed ID: 15063809

DOI: 10.1016/j.bbrc.2004.03.092

PubMed ID: 18779312

Title: Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

PubMed ID: 18779312

DOI: 10.1124/dmd.108.023770

PubMed ID: 17540336

Title: Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.

PubMed ID: 17540336

DOI: 10.1016/j.abb.2007.04.028

PubMed ID: 17428784

Title: Structure of the human lung cytochrome P450 2A13.

PubMed ID: 17428784

DOI: 10.1074/jbc.m702361200

PubMed ID: 12130698

Title: Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.

PubMed ID: 12130698

DOI: 10.1124/jpet.302.2.416

PubMed ID: 15618722

Title: Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.

PubMed ID: 15618722

DOI: 10.2133/dmpk.18.86

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 494
  • Mass: 56688
  • Checksum: A39F18AD71C28821
  • Sequence:
    • MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK 
ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG RGEQATFDWL FKGYGVAFSN 
GERAKQLRRF SIATLRGFGV GKRGIEERIQ EEAGFLIDAL RGTHGANIDP TFFLSRTVSN 
VISSIVFGDR FDYEDKEFLS LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE 
LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YTEAVIHEIQ 
RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR DPRFFSNPRD FNPQHFLDKK 
GQFKKSDAFV PFSIGKRYCF GEGLARMELF LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF 
ATIPRNYTMS FLPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.