Details for: CYP2A13

Gene ID: 1553

Symbol: CYP2A13

Ensembl ID: ENSG00000197838

Description: cytochrome P450 family 2 subfamily A member 13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53067
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3179
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.06
    Marker Score: 2954
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.3
    Marker Score: 2377
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 525.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2414
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.92
    Marker Score: 265
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.87
    Marker Score: 583
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1373
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.78
    Marker Score: 5207
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.78
    Marker Score: 213
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.68
    Marker Score: 336
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.55
    Marker Score: 4072
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1024
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 273
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 754
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.32
    Marker Score: 414
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4713
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.29
    Marker Score: 892
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.28
    Marker Score: 71
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 167
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 753
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.2
    Marker Score: 232.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 490
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.12
    Marker Score: 105.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.11
    Marker Score: 950
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 170
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.07
    Marker Score: 127
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 198
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 107
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.02
    Marker Score: 64
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 18

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Other Information

**Key characteristics:** * The CYP2A13 gene is located on chromosome 19p13.1. * It is a large gene with a molecular weight of approximately 130 kDa. * It contains 13 exons and 12 introns. * The protein encoded by CYP2A13 is a transmembrane protein with a molecular weight of approximately 150 kDa. **Pathways and functions:** * CYP2A13 is involved in the following pathways and functions: * Aflatoxin activation and detoxification * Aflatoxin metabolic process * Arachidonic acid epoxygenase activity * Aromatase activity * Biological oxidations * Coumarin 7-hydroxylase activity * Coumarin metabolic process * Cyp2e1 reactions * Cytochrome p450 - arranged by substrate type * Epoxygenase p450 pathway * Fatty acids * Heme binding * Iron ion binding * Metabolism * Monooxygenase activity * Oxidoreductase activity * Acting on paired donors, with incorporation or reduction of molecular oxygen * Reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen **Clinical significance:** * CYP2A13 gene mutations have been linked to an increased risk of liver cancer and other liver diseases. * CYP2A13 inhibitors are being investigated as potential treatments for cancer and other liver diseases. **Other important points:** * CYP2A13 is a highly expressed gene in many cell types. * It is also expressed in immune cells, where it plays a role in the activation of aflatoxins. * CYP2A13 is a promising target for the development of new therapies for cancer and other liver diseases.

Genular Protein ID: 562174136

Symbol: CP2AD_HUMAN

Name: Cytochrome P450 2A13

UniProtKB Accession Codes:

Q16696 Q53YR8 Q6R569 Q6R570 Q9H2X2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7668294

Title: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

PubMed ID: 7668294

PubMed ID: 11016631

Title: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

PubMed ID: 11016631

PubMed ID: 15063809

Title: Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility.

PubMed ID: 15063809

DOI: 10.1016/j.bbrc.2004.03.092

PubMed ID: 18779312

Title: Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

PubMed ID: 18779312

DOI: 10.1124/dmd.108.023770

PubMed ID: 17540336

Title: Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.

PubMed ID: 17540336

DOI: 10.1016/j.abb.2007.04.028

PubMed ID: 17428784

Title: Structure of the human lung cytochrome P450 2A13.

PubMed ID: 17428784

DOI: 10.1074/jbc.m702361200

PubMed ID: 12130698

Title: Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.

PubMed ID: 12130698

DOI: 10.1124/jpet.302.2.416

PubMed ID: 15618722

Title: Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.

PubMed ID: 15618722

DOI: 10.2133/dmpk.18.86

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 494
  • Mass: 56688
  • Checksum: A39F18AD71C28821
  • Sequence:
    • MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK 
ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG RGEQATFDWL FKGYGVAFSN 
GERAKQLRRF SIATLRGFGV GKRGIEERIQ EEAGFLIDAL RGTHGANIDP TFFLSRTVSN 
VISSIVFGDR FDYEDKEFLS LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE 
LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YTEAVIHEIQ 
RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR DPRFFSNPRD FNPQHFLDKK 
GQFKKSDAFV PFSIGKRYCF GEGLARMELF LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF 
ATIPRNYTMS FLPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.