CYP2A13 | ENSG00000197838 | NCBI 1553

Details for: CYP2A13

Gene ID: 1553

Symbol: CYP2A13

Ensembl ID: ENSG00000197838

Description: cytochrome P450 family 2 subfamily A member 13

Associated with

Aflatoxin activation and detoxification
(R-HSA-5423646)
Biological oxidations
(R-HSA-211859)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Aflatoxin metabolic process
(GO:0046222)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Coumarin 7-hydroxylase activity
(GO:0008389)
Coumarin metabolic process
(GO:0009804)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Epoxygenase p450 pathway
(GO:0019373)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2A13

Genular Protein ID: 562174136

Symbol: CP2AD_HUMAN

Name: Cytochrome P450 2A13

UniProtKB Accession Codes:

Q16696 Q53YR8 Q6R569 Q6R570 Q9H2X2

Database IDs:

Citations:

PubMed ID: 7668294

Title: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

PubMed ID: 7668294

PubMed ID: 11016631

Title: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

PubMed ID: 11016631

PubMed ID: 15063809

Title: Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility.

PubMed ID: 15063809

DOI: 10.1016/j.bbrc.2004.03.092

PubMed ID: 18779312

Title: Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

PubMed ID: 18779312

DOI: 10.1124/dmd.108.023770

PubMed ID: 17540336

Title: Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.

PubMed ID: 17540336

DOI: 10.1016/j.abb.2007.04.028

PubMed ID: 17428784

Title: Structure of the human lung cytochrome P450 2A13.

PubMed ID: 17428784

DOI: 10.1074/jbc.m702361200

PubMed ID: 12130698

Title: Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.

PubMed ID: 12130698

DOI: 10.1124/jpet.302.2.416

PubMed ID: 15618722

Title: Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.

PubMed ID: 15618722

DOI: 10.2133/dmpk.18.86

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

Length: 494
Mass: 56688
Checksum: A39F18AD71C28821
Sequence:

MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK 
ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG RGEQATFDWL FKGYGVAFSN 
GERAKQLRRF SIATLRGFGV GKRGIEERIQ EEAGFLIDAL RGTHGANIDP TFFLSRTVSN 
VISSIVFGDR FDYEDKEFLS LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE 
LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YTEAVIHEIQ 
RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR DPRFFSNPRD FNPQHFLDKK 
GQFKKSDAFV PFSIGKRYCF GEGLARMELF LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF 
ATIPRNYTMS FLPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2A13

Associated with

Other Information

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. PubMed ID: 7668294

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. PubMed ID: 11016631

Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. PubMed ID: 15063809

Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes. PubMed ID: 18779312

Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants. PubMed ID: 17540336

Structure of the human lung cytochrome P450 2A13. PubMed ID: 17428784

Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. PubMed ID: 12130698

Eighteen novel polymorphisms of the CYP2A13 gene in Japanese. PubMed ID: 15618722

Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. PubMed ID: 12721789