CYP2B6 | ENSG00000197408 | NCBI 1555

Details for: CYP2B6

Gene ID: 1555

Symbol: CYP2B6

Ensembl ID: ENSG00000197408

Description: cytochrome P450 family 2 subfamily B member 6

Associated with

Biological oxidations
(R-HSA-211859)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Anandamide 8,9 epoxidase activity
(GO:0062187)
Anandamide 11,12 epoxidase activity
(GO:0062188)
Anandamide 14,15 epoxidase activity
(GO:0062189)
Arachidonic acid epoxygenase activity
(GO:0008392)
Cellular ketone metabolic process
(GO:0042180)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Epoxygenase p450 pathway
(GO:0019373)
Estrogen 2-hydroxylase activity
(GO:0101021)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Steroid metabolic process
(GO:0008202)
Testosterone 16-alpha-hydroxylase activity
(GO:0008390)
Testosterone 16-beta-hydroxylase activity
(GO:0062184)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2B6

Genular Protein ID: 3336004032

Symbol: CP2B6_HUMAN

Name: Cytochrome P450 2B6

UniProtKB Accession Codes:

P20813 B4DWP3 Q2V565 Q9UK46

Database IDs:

Citations:

PubMed ID: 2573390

Title: cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.

PubMed ID: 2573390

DOI: 10.1021/bi00444a029

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2813061

Title: Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.

PubMed ID: 2813061

DOI: 10.1093/nar/17.20.8241

PubMed ID: 10768437

Title: Gene expression in distinct regions of the heart.

PubMed ID: 10768437

DOI: 10.1016/s0140-6736(00)99016-0

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 21289075

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

PubMed ID: 21289075

DOI: 10.1124/dmd.110.036707

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20061448

Title: Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

PubMed ID: 20061448

DOI: 10.1124/mol.109.062570

PubMed ID: 21875942

Title: Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.

PubMed ID: 21875942

DOI: 10.1124/mol.111.074427

PubMed ID: 22909231

Title: Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

PubMed ID: 22909231

DOI: 10.1021/bi300894z

PubMed ID: 15622315

Title: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

PubMed ID: 15622315

PubMed ID: 15194512

Title: Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

PubMed ID: 15194512

DOI: 10.1016/j.bbrc.2004.05.116

PubMed ID: 20639527

Title: Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.

PubMed ID: 20639527

DOI: 10.1093/jac/dkq260

PubMed ID: 20860463

Title: Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.

PubMed ID: 20860463

DOI: 10.2217/pgs.10.94

PubMed ID: 11243870

Title: A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.

PubMed ID: 11243870

DOI: 10.1006/bbrc.2001.4524

PubMed ID: 11470993

Title: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

PubMed ID: 11470993

DOI: 10.1097/00008571-200107000-00004

PubMed ID: 12642465

Title: Functional characterization of cytochrome P450 2B6 allelic variants.

PubMed ID: 12642465

DOI: 10.1124/dmd.31.4.398

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

PubMed ID: 14551287

Title: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

PubMed ID: 14551287

DOI: 10.1124/jpet.103.054866

PubMed ID: 15190123

Title: Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles.

PubMed ID: 15190123

DOI: 10.1124/jpet.104.068973

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

Length: 491
Mass: 56278
Checksum: B9799164BE8FBF1D
Sequence:

MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE 
KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK IAMVDPFFRG YGVIFANGNR 
WKVLRRFSVT TMRDFGMGKR SVEERIQEEA QCLIEELRKS KGALMDPTFL FQSITANIIC 
SIVFGKRFHY QDQEFLKMLN LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE 
INAYIGHSVE KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT 
ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE AVIYEIQRFS 
DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH YFEKPDAFNP DHFLDANGAL 
KKTEAFIPFS LGKRICLGEG IARAELFLFF TTILQNFSMA SPVAPEDIDL TPQECGVGKI 
PPTYQIRFLP R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2B6

Associated with

Other Information

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. PubMed ID: 2573390

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages. PubMed ID: 2813061

Gene expression in distinct regions of the heart. PubMed ID: 10768437

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. PubMed ID: 11695850

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. PubMed ID: 21289075

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. PubMed ID: 20061448

Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. PubMed ID: 21875942

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. PubMed ID: 22909231

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. PubMed ID: 15622315

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. PubMed ID: 15194512

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. PubMed ID: 20639527

Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. PubMed ID: 20860463

A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation. PubMed ID: 11243870

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. PubMed ID: 11470993

Functional characterization of cytochrome P450 2B6 allelic variants. PubMed ID: 12642465

Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. PubMed ID: 12721789

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. PubMed ID: 14551287

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. PubMed ID: 15190123

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410