Gene CYP2B6 - ENSG00000197408 | NCBI Gene ID: 1555

Details for: CYP2B6

Gene ID: 1555

Symbol: CYP2B6

Ensembl ID: ENSG00000197408

Description: cytochrome P450 family 2 subfamily B member 6

Associated with

Biological oxidations
(R-HSA-211859)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Anandamide 8,9 epoxidase activity
(GO:0062187)
Anandamide 11,12 epoxidase activity
(GO:0062188)
Anandamide 14,15 epoxidase activity
(GO:0062189)
Arachidonic acid epoxygenase activity
(GO:0008392)
Cellular ketone metabolic process
(GO:0042180)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Epoxygenase p450 pathway
(GO:0019373)
Estrogen 2-hydroxylase activity
(GO:0101021)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Steroid metabolic process
(GO:0008202)
Testosterone 16-alpha-hydroxylase activity
(GO:0008390)
Testosterone 16-beta-hydroxylase activity
(GO:0062184)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.1
Marker Score: 11289
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.69
Marker Score: 10876
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.63
Marker Score: 7039
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.42
Marker Score: 663
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.15
Marker Score: 1233
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.03
Marker Score: 1945
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71825
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48050
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5329
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.92
Marker Score: 618
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.79
Marker Score: 838
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: secretory cell (CL0000151)
Fold Change: 0.77
Marker Score: 1404
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.77
Marker Score: 1556
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 694
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.69
Marker Score: 262
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.69
Marker Score: 215
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: mast cell (CL0000097)
Fold Change: 0.67
Marker Score: 391
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.61
Marker Score: 389
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 471
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.58
Marker Score: 346
Cell Name: club cell (CL0000158)
Fold Change: 0.56
Marker Score: 653
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.55
Marker Score: 8580
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.5
Marker Score: 341
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.5
Marker Score: 3694
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.49
Marker Score: 1756
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.49
Marker Score: 136
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.43
Marker Score: 159
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.42
Marker Score: 194
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.38
Marker Score: 1322
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.38
Marker Score: 378
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.37
Marker Score: 185
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.37
Marker Score: 371
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.36
Marker Score: 559
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.32
Marker Score: 219
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.32
Marker Score: 1013
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.31
Marker Score: 149
Cell Name: lactocyte (CL0002325)
Fold Change: 0.29
Marker Score: 4658
Cell Name: ionocyte (CL0005006)
Fold Change: 0.28
Marker Score: 86
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.28
Marker Score: 1841
Cell Name: Unknown (CL0000003)
Fold Change: 0.28
Marker Score: 858
Cell Name: enterocyte (CL0000584)
Fold Change: 0.27
Marker Score: 1316
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.27
Marker Score: 74
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.26
Marker Score: 74
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.25
Marker Score: 714
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.23
Marker Score: 125
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.23
Marker Score: 65
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.22
Marker Score: 271
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.22
Marker Score: 1155
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.22
Marker Score: 101
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.21
Marker Score: 78
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.2
Marker Score: 53
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.2
Marker Score: 62
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2
Marker Score: 81
Cell Name: basal cell (CL0000646)
Fold Change: 0.19
Marker Score: 251
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.19
Marker Score: 166
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.18
Marker Score: 81
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.17
Marker Score: 1490
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.16
Marker Score: 111
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.16
Marker Score: 71
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.15
Marker Score: 46
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.14
Marker Score: 275
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.14
Marker Score: 35
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.13
Marker Score: 89
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.12
Marker Score: 124
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.12
Marker Score: 248
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.12
Marker Score: 88
Cell Name: macrophage (CL0000235)
Fold Change: 0.12
Marker Score: 129
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.12
Marker Score: 25.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.12
Marker Score: 103
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.12
Marker Score: 27
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.11
Marker Score: 266
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.11
Marker Score: 22
Cell Name: acinar cell (CL0000622)
Fold Change: 0.11
Marker Score: 79
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.11
Marker Score: 196
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.11
Marker Score: 24
Cell Name: pericyte (CL0000669)
Fold Change: 0.11
Marker Score: 64
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.11
Marker Score: 28
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.11
Marker Score: 29
Cell Name: stem cell (CL0000034)
Fold Change: 0.1
Marker Score: 249
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.1
Marker Score: 59
Cell Name: astrocyte (CL0000127)
Fold Change: 0.1
Marker Score: 89
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.1
Marker Score: 63
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.1
Marker Score: 21.5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.09
Marker Score: 147
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.09
Marker Score: 22.5
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.09
Marker Score: 25.5

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**Key characteristics:** * The CYP2B6 gene is located on chromosome 17q21.1. * The gene is approximately 2.7 kb in length. * CYP2B6 is a transmembrane protein that is composed of 131 amino acids. * The enzyme is a member of the cytochrome P450 family of proteins. * CYP2B6 is a multi-functional enzyme that can perform a variety of different reactions. **Pathways and functions:** * CYP2B6 is involved in the metabolism of a variety of drugs, including cyclophosphamide, methotrexate, and warfarin. * The enzyme is also involved in the metabolism of hormones, such as estrogen and testosterone. * CYP2B6 is also involved in the metabolism of dietary compounds, such as fatty acids and xenobiotics. **Clinical significance:** * Mutations in the CYP2B6 gene have been linked to a number of human diseases, including liver disease, cancer, and metabolic disorders. * CYP2B6 inhibitors are being developed as potential treatments for these diseases. **Additional information:** * CYP2B6 is a highly expressed gene in the liver. * The enzyme is regulated by a variety of factors, including hormones, nutrients, and toxins. * CYP2B6 is a well-characterized enzyme that has been extensively studied in both animal and human systems.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytochrome P450 2B6

Genular Protein ID: 3336004032

Symbol: CP2B6_HUMAN

Name: Cytochrome P450 2B6

UniProtKB Accession Codes:

P20813 B4DWP3 Q2V565 Q9UK46

Database IDs:

Citations:

PubMed ID: 2573390

Title: cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.

PubMed ID: 2573390

DOI: 10.1021/bi00444a029

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2813061

Title: Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.

PubMed ID: 2813061

DOI: 10.1093/nar/17.20.8241

PubMed ID: 10768437

Title: Gene expression in distinct regions of the heart.

PubMed ID: 10768437

DOI: 10.1016/s0140-6736(00)99016-0

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 21289075

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

PubMed ID: 21289075

DOI: 10.1124/dmd.110.036707

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20061448

Title: Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

PubMed ID: 20061448

DOI: 10.1124/mol.109.062570

PubMed ID: 21875942

Title: Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.

PubMed ID: 21875942

DOI: 10.1124/mol.111.074427

PubMed ID: 22909231

Title: Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

PubMed ID: 22909231

DOI: 10.1021/bi300894z

PubMed ID: 15622315

Title: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

PubMed ID: 15622315

PubMed ID: 15194512

Title: Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

PubMed ID: 15194512

DOI: 10.1016/j.bbrc.2004.05.116

PubMed ID: 20639527

Title: Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.

PubMed ID: 20639527

DOI: 10.1093/jac/dkq260

PubMed ID: 20860463

Title: Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.

PubMed ID: 20860463

DOI: 10.2217/pgs.10.94

PubMed ID: 11243870

Title: A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.

PubMed ID: 11243870

DOI: 10.1006/bbrc.2001.4524

PubMed ID: 11470993

Title: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

PubMed ID: 11470993

DOI: 10.1097/00008571-200107000-00004

PubMed ID: 12642465

Title: Functional characterization of cytochrome P450 2B6 allelic variants.

PubMed ID: 12642465

DOI: 10.1124/dmd.31.4.398

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

PubMed ID: 14551287

Title: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

PubMed ID: 14551287

DOI: 10.1124/jpet.103.054866

PubMed ID: 15190123

Title: Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles.

PubMed ID: 15190123

DOI: 10.1124/jpet.104.068973

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

Length: 491
Mass: 56278
Checksum: B9799164BE8FBF1D
Sequence:

MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE 
KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK IAMVDPFFRG YGVIFANGNR 
WKVLRRFSVT TMRDFGMGKR SVEERIQEEA QCLIEELRKS KGALMDPTFL FQSITANIIC 
SIVFGKRFHY QDQEFLKMLN LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE 
INAYIGHSVE KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT 
ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE AVIYEIQRFS 
DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH YFEKPDAFNP DHFLDANGAL 
KKTEAFIPFS LGKRICLGEG IARAELFLFF TTILQNFSMA SPVAPEDIDL TPQECGVGKI 
PPTYQIRFLP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CYP2B6

Associated with

Cells (max top 100)

Other Information

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. PubMed ID: 2573390

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages. PubMed ID: 2813061

Gene expression in distinct regions of the heart. PubMed ID: 10768437

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. PubMed ID: 11695850

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. PubMed ID: 21289075

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. PubMed ID: 20061448

Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. PubMed ID: 21875942

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. PubMed ID: 22909231

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. PubMed ID: 15622315

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. PubMed ID: 15194512

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. PubMed ID: 20639527

Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. PubMed ID: 20860463

A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation. PubMed ID: 11243870

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. PubMed ID: 11470993

Functional characterization of cytochrome P450 2B6 allelic variants. PubMed ID: 12642465

Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. PubMed ID: 12721789

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. PubMed ID: 14551287

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. PubMed ID: 15190123

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410