Genular: Defining Cellular Identity and Function

Details for: Htr1a

Gene ID: 15550

Symbol: Htr1a

Ensembl ID: ENSMUSG00000021721

Description: 5-hydroxytryptamine (serotonin) receptor 1A

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Gpcr ligand binding
(R-MMU-500792)
Serotonin receptors
(R-MMU-390666)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway
(GO:0007198)
Axon hillock
(GO:0043203)
Behavior
(GO:0007610)
Behavioral fear response
(GO:0001662)
Cell projection
(GO:0042995)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Exploration behavior
(GO:0035640)
G-protein alpha-subunit binding
(GO:0001965)
Gaba-ergic synapse
(GO:0098982)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Membrane
(GO:0016020)
Negative regulation of gamma-aminobutyric acid secretion
(GO:0014053)
Neuronal cell body
(GO:0043025)
Neurotransmitter receptor activity
(GO:0030594)
Nmda glutamate receptor clustering
(GO:0097114)
Plasma membrane
(GO:0005886)
Positive regulation of microtubule depolymerization
(GO:0031117)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Receptor-receptor interaction
(GO:0090722)
Regulation of behavior
(GO:0050795)
Regulation of dopamine metabolic process
(GO:0042053)
Regulation of feeding behavior
(GO:0060259)
Regulation of hormone secretion
(GO:0046883)
Regulation of serotonin secretion
(GO:0014062)
Regulation of vasoconstriction
(GO:0019229)
Serotonin binding
(GO:0051378)
Serotonin metabolic process
(GO:0042428)
Serotonin receptor signaling pathway
(GO:0007210)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)

Other Information

Proteins

5-hydroxytryptamine receptor 1A

Genular Protein ID: 1761634244

Symbol: 5HT1A_MOUSE

Name: 5-hydroxytryptamine receptor 1A

UniProtKB Accession Codes:

Q64264 Q60956 Q61617 Q8BGS4

Database IDs:

Citations:

PubMed ID: 8254366

Title: Cloning and differentiation-induced expression of a murine serotonin 1A receptor in a septal cell line.

PubMed ID: 8254366

DOI: 10.1523/jneurosci.13-12-05164.1993

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626793

Title: The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1.

PubMed ID: 8626793

DOI: 10.1074/jbc.271.8.4417

PubMed ID: 8288218

Title: Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.

PubMed ID: 8288218

DOI: 10.1006/geno.1993.1452

PubMed ID: 9826725

Title: Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.

PubMed ID: 9826725

DOI: 10.1073/pnas.95.24.14476

PubMed ID: 11080193

Title: Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice.

PubMed ID: 11080193

DOI: 10.1046/j.1471-4159.2000.0752415.x

PubMed ID: 17543467

Title: Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants.

PubMed ID: 17543467

DOI: 10.1016/j.neuroscience.2007.04.004

PubMed ID: 18599790

Title: Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.

PubMed ID: 18599790

DOI: 10.1126/science.1157871

PubMed ID: 21508226

Title: Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety.

PubMed ID: 21508226

DOI: 10.1523/jneurosci.5836-10.2011

Sequence Information:

Length: 421
Mass: 46176
Checksum: 74F519DF7CC0C7AA
Sequence:

MDMFSLGQGN NTTTSLEPFG TGGNDTGLSN VTFSYQVITS LLLGTLIFCA VLGNACVVAA 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 
RSNPNECTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKKGAGT 
SFGTSSAPPP KKSLNGQPGS GDCRRSAENR AVGTPCANGA VRQGEDDATL EVIEVHRVGN 
SKGHLPLPSE SGATSYVPAC LERKNERTAE AKRKMALARE RKTVKTLGII MGTFILCWLP 
FFIVALVLPF CESSCHMPEL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 
R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htr1a

Associated with

Other Information

Cloning and differentiation-induced expression of a murine serotonin 1A receptor in a septal cell line. PubMed ID: 8254366

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. PubMed ID: 8626793

Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. PubMed ID: 8288218

Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. PubMed ID: 9826725

Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice. PubMed ID: 11080193

Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. PubMed ID: 17543467

Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. PubMed ID: 18599790

Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. PubMed ID: 21508226