Genular: Defining Cellular Identity and Function

Details for: Htr1b

Gene ID: 15551

Symbol: Htr1b

Ensembl ID: ENSMUSG00000049511

Description: 5-hydroxytryptamine (serotonin) receptor 1B

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Serotonin receptors
(R-MMU-390666)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway
(GO:0007198)
Behavior
(GO:0007610)
Bone remodeling
(GO:0046849)
Calyx of held
(GO:0044305)
Cellular response to alkaloid
(GO:0071312)
Cellular response to temperature stimulus
(GO:0071502)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chemical synaptic transmission
(GO:0007268)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Drinking behavior
(GO:0042756)
Endoplasmic reticulum
(GO:0005783)
Feeding behavior
(GO:0007631)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor internalization
(GO:0002031)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor complex
(GO:0098666)
Heterocyclic compound binding
(GO:1901363)
Membrane
(GO:0016020)
Negative regulation of gamma-aminobutyric acid secretion
(GO:0014053)
Negative regulation of serotonin secretion
(GO:0014063)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Negative regulation of synaptic transmission, glutamatergic
(GO:0051967)
Neurotransmitter receptor activity
(GO:0030594)
Plasma membrane
(GO:0005886)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of behavior
(GO:0050795)
Regulation of dopamine secretion
(GO:0014059)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to toxic substance
(GO:0009636)
Serotonergic synapse
(GO:0099154)
Serotonin binding
(GO:0051378)
Signal transduction
(GO:0007165)
Vasoconstriction
(GO:0042310)
Voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
(GO:0099626)

Other Information

Proteins

5-hydroxytryptamine receptor 1B

Genular Protein ID: 597797150

Symbol: 5HT1B_MOUSE

Name: 5-hydroxytryptamine receptor 1B

UniProtKB Accession Codes:

P28334

Database IDs:

Citations:

PubMed ID: 1557407

Title: Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

PubMed ID: 1557407

DOI: 10.1073/pnas.89.7.3020

PubMed ID: 8091214

Title: Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

PubMed ID: 8091214

DOI: 10.1126/science.8091214

PubMed ID: 8742487

Title: Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice.

PubMed ID: 8742487

PubMed ID: 9349547

Title: Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies.

PubMed ID: 9349547

DOI: 10.1046/j.1471-4159.1997.69052019.x

PubMed ID: 10651141

Title: 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice.

PubMed ID: 10651141

DOI: 10.1007/s002109900163

PubMed ID: 16750486

Title: Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice.

PubMed ID: 16750486

DOI: 10.1016/j.brainresbull.2006.04.004

Sequence Information:

Length: 386
Mass: 43079
Checksum: 58F70FBEA770C0B3
Sequence:

MEEQGIQCAP PPPAASQTGV PLTNLSHNCS ADGYIYQDSI ALPWKVLLVA LLALITLATT 
LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP ISTMYTVTGR WTLGQVVCDF 
WLSSDITCCT ASIMHLCVIA LDRYWAITDA VEYSAKRTPK RAAIMIVLVW VFSISISLPP 
FFWRQAKAEE EMLDCFVNTD HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP 
NKTGKRLTRA QLITDSPGST SSVTSINSRA PDVPSESGSP VYVNQVKVRV SDALLEKKKL 
MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF NWLGYLNSLI 
NPIIYTMSNE DFKQAFHKLI RFKCAG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htr1b

Associated with

Other Information

Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. PubMed ID: 1557407

Enhanced aggressive behavior in mice lacking 5-HT1B receptor. PubMed ID: 8091214

Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice. PubMed ID: 8742487

Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. PubMed ID: 9349547

5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice. PubMed ID: 10651141