Genular: Defining Cellular Identity and Function

Details for: Htr2a

Gene ID: 15558

Symbol: Htr2a

Ensembl ID: ENSMUSG00000034997

Description: 5-hydroxytryptamine (serotonin) receptor 2A

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Serotonin receptors
(R-MMU-390666)
Signaling by gpcr
(R-MMU-372790)
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
(GO:0071886)
Activation of phospholipase c activity
(GO:0007202)
Artery smooth muscle contraction
(GO:0014824)
Behavior
(GO:0007610)
Behavioral response to cocaine
(GO:0048148)
Cell body fiber
(GO:0070852)
Cell projection
(GO:0042995)
Chemical synaptic transmission
(GO:0007268)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dendritic shaft
(GO:0043198)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Glutamatergic synapse
(GO:0098978)
Glycolytic process
(GO:0006096)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor complex
(GO:0098666)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Gq/11-coupled serotonin receptor activity
(GO:0001587)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of synaptic transmission, glutamatergic
(GO:0051967)
Neuronal cell body
(GO:0043025)
Neurotransmitter receptor activity
(GO:0030594)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase c-activating serotonin receptor signaling pathway
(GO:0007208)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol biosynthetic process
(GO:0010513)
Positive regulation of vasoconstriction
(GO:0045907)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex binding
(GO:0044877)
Protein localization to cytoskeleton
(GO:0044380)
Protein tyrosine kinase activator activity
(GO:0030296)
Regulation of dopamine secretion
(GO:0014059)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to xenobiotic stimulus
(GO:0009410)
Serotonin binding
(GO:0051378)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Temperature homeostasis
(GO:0001659)
Urinary bladder smooth muscle contraction
(GO:0014832)

Other Information

Proteins

5-hydroxytryptamine receptor 2A

Genular Protein ID: 2100368498

Symbol: 5HT2A_MOUSE

Name: 5-hydroxytryptamine receptor 2A

UniProtKB Accession Codes:

P35363

Database IDs:

Citations:

PubMed ID: 1333538

Title: Gene structure and expression of the mouse 5-HT2 receptor.

PubMed ID: 1333538

DOI: 10.1002/jnr.490330203

PubMed ID: 11960784

Title: 5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice.

PubMed ID: 11960784

DOI: 10.1152/ajpgi.00435.2001

PubMed ID: 14988405

Title: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

PubMed ID: 14988405

DOI: 10.1074/jbc.m312106200

PubMed ID: 16873667

Title: Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

PubMed ID: 16873667

DOI: 10.1126/science.1123432

PubMed ID: 17270739

Title: Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.

PubMed ID: 17270739

DOI: 10.1016/j.neuron.2007.01.008

PubMed ID: 18297054

Title: Identification of a serotonin/glutamate receptor complex implicated in psychosis.

PubMed ID: 18297054

DOI: 10.1038/nature06612

PubMed ID: 21645528

Title: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

PubMed ID: 21645528

DOI: 10.1016/j.neuropharm.2011.05.023

PubMed ID: 23346101

Title: 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.

PubMed ID: 23346101

DOI: 10.1155/2012/398406

PubMed ID: 23129762

Title: Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function.

PubMed ID: 23129762

DOI: 10.1074/jbc.m112.413161

Sequence Information:

Length: 471
Mass: 52842
Checksum: DE763E5617EE8435
Sequence:

MEILCEDNIS LSSIPNSLMQ LGDDSRLYPN DFNSRDANTS EASNWTIDAE NRTNLSCEGY 
LPPTCLSILH LQEKNWSALL TTVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD 
MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP 
IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF 
VAFFIPLTIM VITYFLTIKS LQKEATLCVS DLSTRAKLSS FSFLPQSSLS SEKLFQRSIH 
REPGSYAGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNENVIGA 
LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENRKPLQLIL VNTIPTLAYK 
SSQLQVGQKK NSQEDAEPTA NDCSMVTLGN QHSEEMCTDN IETVNEKVSC V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htr2a

Associated with

Other Information

Gene structure and expression of the mouse 5-HT2 receptor. PubMed ID: 1333538

5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice. PubMed ID: 11960784

The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. PubMed ID: 14988405

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. PubMed ID: 16873667

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. PubMed ID: 17270739

Identification of a serotonin/glutamate receptor complex implicated in psychosis. PubMed ID: 18297054

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. PubMed ID: 21645528

5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. PubMed ID: 23346101

Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. PubMed ID: 23129762