Genular: Defining Cellular Identity and Function

Details for: Htr2b

Gene ID: 15559

Symbol: Htr2b

Ensembl ID: ENSMUSG00000026228

Description: 5-hydroxytryptamine (serotonin) receptor 2B

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Serotonin receptors
(R-MMU-390666)
Signaling by gpcr
(R-MMU-372790)
Activation of phospholipase c activity
(GO:0007202)
Behavior
(GO:0007610)
Calcium-mediated signaling
(GO:0019722)
Cardiac muscle hypertrophy
(GO:0003300)
Cellular response to amine stimulus
(GO:0071418)
Cellular response to serotonin
(GO:1904015)
Cellular response to temperature stimulus
(GO:0071502)
Cgmp-mediated signaling
(GO:0019934)
Chemical synaptic transmission
(GO:0007268)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Embryonic morphogenesis
(GO:0048598)
Erk1 and erk2 cascade
(GO:0070371)
G-protein alpha-subunit binding
(GO:0001965)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor internalization
(GO:0002031)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor complex
(GO:0098666)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Gq/11-coupled serotonin receptor activity
(GO:0001587)
Gtpase activator activity
(GO:0005096)
Heart development
(GO:0007507)
Heart morphogenesis
(GO:0003007)
Intestine smooth muscle contraction
(GO:0014827)
Intracellular calcium ion homeostasis
(GO:0006874)
Membrane
(GO:0016020)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of apoptotic process
(GO:0043066)
Neural crest cell differentiation
(GO:0014033)
Neural crest cell migration
(GO:0001755)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Neurotransmitter receptor activity
(GO:0030594)
Nucleoplasm
(GO:0005654)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase c-activating serotonin receptor signaling pathway
(GO:0007208)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of phosphatidylinositol biosynthetic process
(GO:0010513)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein kinase c signaling
(GO:0070528)
Regulation of behavior
(GO:0050795)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to xenobiotic stimulus
(GO:0009410)
Serotonin binding
(GO:0051378)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Synapse
(GO:0045202)
Vasoconstriction
(GO:0042310)

Other Information

Proteins

5-hydroxytryptamine receptor 2B

Genular Protein ID: 3287204590

Symbol: 5HT2B_MOUSE

Name: 5-hydroxytryptamine receptor 2B

UniProtKB Accession Codes:

Q02152 Q8JZK5 Q9QWS2

Database IDs:

Citations:

PubMed ID: 1426253

Title: New mouse 5-HT2-like receptor. Expression in brain, heart and intestine.

PubMed ID: 1426253

DOI: 10.1016/0014-5793(92)80936-b

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10944220

Title: Serotonin 2B receptor is required for heart development.

PubMed ID: 10944220

DOI: 10.1073/pnas.97.17.9508

PubMed ID: 11413089

Title: Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.

PubMed ID: 11413089

DOI: 10.1161/01.cir.103.24.2973

PubMed ID: 12244304

Title: Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension.

PubMed ID: 12244304

DOI: 10.1038/nm764

PubMed ID: 12738797

Title: Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.

PubMed ID: 12738797

DOI: 10.1096/fj.02-1122fje

PubMed ID: 16940156

Title: Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells.

PubMed ID: 16940156

DOI: 10.1096/fj.06-5724com

PubMed ID: 17846081

Title: The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation.

PubMed ID: 17846081

DOI: 10.1096/fj.07-9209com

PubMed ID: 18337424

Title: Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro.

PubMed ID: 18337424

DOI: 10.1523/jneurosci.5723-07.2008

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

PubMed ID: 19941613

Title: Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.

PubMed ID: 19941613

DOI: 10.1111/j.1365-2982.2009.01435.x

PubMed ID: 21273425

Title: Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia.

PubMed ID: 21273425

DOI: 10.1523/jneurosci.4682-10.2011

PubMed ID: 23346101

Title: 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.

PubMed ID: 23346101

DOI: 10.1155/2012/398406

Sequence Information:

Length: 479
Mass: 53597
Checksum: F02B30D80C8C9B6D
Sequence:

MASSYKMSEQ STTSEHILQK TCDHLILTNR SGLETDSVAE EMKQTVEGQG HTVHWAALLI 
LAVIIPTIGG NILVILAVAL EKRLQYATNY FLMSLAIADL LVGLFVMPIA LLTIMFEAIW 
PLPLALCPAW LFLDVLFSTA SIMHLCAISL DRYIAIKKPI QANQCNSRAT AFIKITVVWL 
ISIGIAIPVP IKGIETDVIN PHNVTCELTK DRFGSFMVFG SLAAFFAPLT IMVVTYFLTI 
HTLQKKAYLV KNKPPQRLTR WTVPTVFLRE DSSFSSPEKV AMLDGSHRDK ILPNSSDETL 
MRRMSSVGKR SAQTISNEQR ASKALGVVFF LFLLMWCPFF ITNLTLALCD SCNQTTLKTL 
LEIFVWIGYV SSGVNPLIYT LFNKTFREAF GRYITCNYRA TKSVKALRKF SSTLCFGNSM 
VENSKFFTKH GIRNGINPAM YQSPMRLRSS TIQSSSIILL DTLLTENDGD KAEEQVSYI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htr2b

Associated with

Other Information

New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. PubMed ID: 1426253

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Serotonin 2B receptor is required for heart development. PubMed ID: 10944220

Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function. PubMed ID: 11413089

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. PubMed ID: 12244304

Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. PubMed ID: 12738797

Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. PubMed ID: 16940156

The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. PubMed ID: 17846081

Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro. PubMed ID: 18337424

A population-specific HTR2B stop codon predisposes to severe impulsivity. PubMed ID: 21179162

Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. PubMed ID: 19941613

Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia. PubMed ID: 21273425

5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. PubMed ID: 23346101