Genular: Defining Cellular Identity and Function

Details for: Htr2c

Gene ID: 15560

Symbol: Htr2c

Ensembl ID: ENSMUSG00000041380

Description: 5-hydroxytryptamine (serotonin) receptor 2C

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Serotonin receptors
(R-MMU-390666)
Signaling by gpcr
(R-MMU-372790)
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
(GO:0071886)
Behavior
(GO:0007610)
Behavioral fear response
(GO:0001662)
Behavioral response to nicotine
(GO:0035095)
Cell surface
(GO:0009986)
Cgmp-mediated signaling
(GO:0019934)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
External side of plasma membrane
(GO:0009897)
Feeding behavior
(GO:0007631)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor complex
(GO:0098666)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Gq/11-coupled serotonin receptor activity
(GO:0001587)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Negative regulation of dopamine metabolic process
(GO:0045963)
Neurotransmitter receptor activity
(GO:0030594)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase c-activating serotonin receptor signaling pathway
(GO:0007208)
Phospholipase d-activating g protein-coupled receptor signaling pathway
(GO:0031583)
Plasma membrane
(GO:0005886)
Positive regulation of acetylcholine secretion, neurotransmission
(GO:0014057)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gamma-aminobutyric acid secretion
(GO:0014054)
Positive regulation of phosphatidylinositol biosynthetic process
(GO:0010513)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Regulation of appetite
(GO:0032098)
Regulation of corticotropin-releasing hormone secretion
(GO:0043397)
Regulation of nervous system process
(GO:0031644)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to xenobiotic stimulus
(GO:0009410)
Serotonin binding
(GO:0051378)
Signal transduction
(GO:0007165)

Other Information

Proteins

5-hydroxytryptamine receptor 1C
Q8BZI5_MOUSE

Genular Protein ID: 3317146402

Symbol: 5HT2C_MOUSE

Name: 5-hydroxytryptamine receptor 1C

UniProtKB Accession Codes:

P34968 B1ATN5 Q5WRU6

Database IDs:

Citations:

PubMed ID: 1661811

Title: The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked.

PubMed ID: 1661811

DOI: 10.1016/0169-328x(91)90116-f

PubMed ID: 1381232

Title: Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes.

PubMed ID: 1381232

DOI: 10.1097/00001756-199204000-00014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 7700379

Title: Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors.

PubMed ID: 7700379

DOI: 10.1038/374542a0

PubMed ID: 9771748

Title: Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene.

PubMed ID: 9771748

DOI: 10.1038/2647

PubMed ID: 16914526

Title: Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.

PubMed ID: 16914526

DOI: 10.1091/mbc.e06-03-0218

PubMed ID: 17451451

Title: Serotonin 5-HT(2C) receptors regulate anxiety-like behavior.

PubMed ID: 17451451

DOI: 10.1111/j.1601-183x.2007.00316.x

PubMed ID: 17596444

Title: Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

PubMed ID: 17596444

DOI: 10.1523/jneurosci.2584-06.2007

PubMed ID: 19038216

Title: 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

PubMed ID: 19038216

DOI: 10.1016/j.neuron.2008.09.033

PubMed ID: 19501602

Title: Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

PubMed ID: 19501602

DOI: 10.1016/j.neuropharm.2009.05.011

PubMed ID: 21048120

Title: A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.

PubMed ID: 21048120

DOI: 10.1523/jneurosci.5412-09.2010

PubMed ID: 21037584

Title: 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

PubMed ID: 21037584

DOI: 10.1038/nn.2664

PubMed ID: 21835345

Title: Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

PubMed ID: 21835345

DOI: 10.1016/j.neuron.2011.06.012

Sequence Information:

Length: 459
Mass: 51929
Checksum: AA3C537B2ADCB0C9
Sequence:

MVNLGTAVRS LLVHLIGLLV WQFDISISPV AAIVTDTFNS SDGGRLFQFP DGVQNWPALS 
IVVIIIMTIG GNILVIMAVS MEKKLHNATN YFLMSLAIAD MLVGLLVMPL SLLAILYDYV 
WPLPRYLCPV WISLDVLFST ASIMHLCAIS LDRYVAIRNP IEHSRFNSRT KAIMKIAIVW 
AISIGVSVPI PVIGLRDESK VFVNNTTCVL NDPNFVLIGS FVAFFIPLTI MVITYFLTIY 
VLRRQTLMLL RGHTEEELRN ISLNFLKCCC KKGDEEENAP NPNPDQKPRR KKKEKRPRGT 
MQAINNEKKA SKVLGIVFFV FLIMWCPFFI TNILSVLCGK ACNQKLMEKL LNVFVWIGYV 
CSGINPLVYT LFNKIYRRAF SKYLRCDYKP DKKPPVRQIP RVAATALSGR ELNVNIYRHT 
NERVVRKAND TEPGIEMQVE NLELPVNPSN VVSERISSV

Genular Protein ID: 3352142770

Symbol: Q8BZI5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BZI5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 459
Mass: 51915
Checksum: 478F09FF476279FE
Sequence:

MVNLGTAVRS LLVHLIGLLV WQFDISISPV AAIVTDTFNS SDGGRLFQFP DGVQNWPALS 
IVVIIIMTIG GNILVIMAVS MEKKLHNATN YFLMSLAIAD MLVGLLVMPL SLLAILYDYV 
WPLPRYLCPV WISLDVLFST ASIMHLCAIS LDRYVAVRNP IEHSRFNSRT KAIMKIAIVW 
AISIGVSVPI PVIGLRDESK VFVNNTTCVL NDPNFVLIGS FVAFFIPLTI MVITYFLTIY 
VLRRQTLMLL RGHTEEELRN ISLNFLKCCC KKGDEEENAP NPNPDQKPRR KKKEKRPRGT 
MQAINNEKKA SKVLGIVFFV FLIMWCPFFI TNILSVLCGK ACNQKLMEKL LNVFVWIGYV 
CSGINPLVYT LFNKIYRRAF SKYLRCDYKP DKKPPVRQIP RVAATALSGR ELNVNIYRHT 
NERVVRKAND TEPGIEMQVE NLELPVNPSN VVSERISSV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htr2c

Associated with

Other Information

The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked. PubMed ID: 1661811

Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. PubMed ID: 1381232

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. PubMed ID: 7700379

Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. PubMed ID: 9771748

Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. PubMed ID: 16914526

Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. PubMed ID: 17451451

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. PubMed ID: 17596444

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. PubMed ID: 19038216

Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. PubMed ID: 19501602

A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. PubMed ID: 21048120

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. PubMed ID: 21037584

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. PubMed ID: 21835345

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073