Genular: Defining Cellular Identity and Function

Details for: Slc6a4

Gene ID: 15567

Symbol: Slc6a4

Ensembl ID: ENSMUSG00000020838

Description: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Associated with

Neuronal system
(R-MMU-112316)
Neurotransmitter clearance
(R-MMU-112311)
Serotonin clearance from the synaptic cleft
(R-MMU-380615)
Transmission across chemical synapses
(R-MMU-112315)
Actin filament binding
(GO:0051015)
Amino acid transport
(GO:0006865)
Anchoring junction
(GO:0070161)
Antiporter activity
(GO:0015297)
Brain morphogenesis
(GO:0048854)
Cell projection
(GO:0042995)
Cellular response to cgmp
(GO:0071321)
Cellular response to organic substance
(GO:0071310)
Circadian rhythm
(GO:0007623)
Cocaine binding
(GO:0019811)
Endomembrane system
(GO:0012505)
Endosome
(GO:0005768)
Enteric nervous system development
(GO:0048484)
Focal adhesion
(GO:0005925)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Membrane raft
(GO:0045121)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Monoamine transmembrane transporter activity
(GO:0008504)
Monoamine transport
(GO:0015844)
Monoatomic cation channel activity
(GO:0005261)
Negative regulation of cerebellar granule cell precursor proliferation
(GO:0021941)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of organ growth
(GO:0046621)
Negative regulation of synaptic transmission, dopaminergic
(GO:0032227)
Neuron projection
(GO:0043005)
Neurotransmitter reuptake
(GO:0098810)
Neurotransmitter transmembrane transporter activity
(GO:0005326)
Neurotransmitter transport
(GO:0006836)
Nitric-oxide synthase binding
(GO:0050998)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of serotonin secretion
(GO:0014064)
Postsynaptic membrane
(GO:0045211)
Presynapse
(GO:0098793)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Regulation of thalamus size
(GO:0090067)
Response to toxic substance
(GO:0009636)
Serotonergic synapse
(GO:0099154)
Serotonin:sodium:chloride symporter activity
(GO:0005335)
Serotonin binding
(GO:0051378)
Serotonin transport
(GO:0006837)
Serotonin uptake
(GO:0051610)
Social behavior
(GO:0035176)
Sodium ion binding
(GO:0031402)
Sodium ion transmembrane transport
(GO:0035725)
Sperm ejaculation
(GO:0042713)
Synapse
(GO:0045202)
Syntaxin-1 binding
(GO:0017075)
Vasoconstriction
(GO:0042310)

Other Information

Proteins

5HT transporter

Genular Protein ID: 3021311812

Symbol: SC6A4_MOUSE

Name: 5HT transporter

UniProtKB Accession Codes:

Q60857 O35241 Q5NCR6

Database IDs:

Citations:

PubMed ID: 9037532

Title: Cloning and expression of the mouse serotonin transporter.

PubMed ID: 9037532

DOI: 10.1016/s0169-328x(96)00172-6

PubMed ID: 9073170

Title: Gene structure and 5'-flanking regulatory region of the murine serotonin transporter.

PubMed ID: 9073170

DOI: 10.1016/s0169-328x(96)00234-3

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8507984

Title: Murine serotonin transporter: sequence and localization to chromosome 11.

PubMed ID: 8507984

DOI: 10.1007/bf00417438

PubMed ID: 9547354

Title: Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice.

PubMed ID: 9547354

DOI: 10.1124/mol.53.4.649

PubMed ID: 16803896

Title: Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.

PubMed ID: 16803896

DOI: 10.1074/jbc.m603877200

PubMed ID: 17452640

Title: Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.

PubMed ID: 17452640

DOI: 10.1073/pnas.0610964104

PubMed ID: 18317590

Title: Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.

PubMed ID: 18317590

DOI: 10.1172/jci33374

PubMed ID: 20676059

Title: Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.

PubMed ID: 20676059

DOI: 10.1038/emboj.2010.172

PubMed ID: 22572884

Title: Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.

PubMed ID: 22572884

DOI: 10.1124/mol.112.079079

PubMed ID: 25600870

Title: Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development.

PubMed ID: 25600870

DOI: 10.1016/j.celrep.2014.12.033

PubMed ID: 27111230

Title: Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

PubMed ID: 27111230

DOI: 10.1172/jci84877

PubMed ID: 29038237

Title: The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

PubMed ID: 29038237

DOI: 10.1523/jneurosci.1482-17.2017

Sequence Information:

Length: 630
Mass: 70048
Checksum: 2B6ABD26E3288CD0
Sequence:

METTPLNSQK VLSECKDKED CQENGVLQKG VPTPADKAGP GQISNGYSAV PSTSAGDEAP 
HSTPAATTTL VAEIHQGERE TWGKKMDFLL SVIGYAVDLG NIWRFPYICY QNGGGAFLLP 
YTIMAIFGGI PLFYMELALG QYHRNGCISI WKKICPIFKG IGYAICIIAF YIASYYNTII 
AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFAQDNITW TLHSTSPAEE FYLRHVLQIH 
QSKGLQDLGT ISWQLALCIM LIFTIIYFSI WKGVKTSGKV VWVTATFPYI VLSVLLVRGA 
TLPGAWRGVV FYLKPNWQKL LETGVWVDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 
ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 
TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHIWAK RREWFVLIVV ITCILGSLLT 
LTSGGAYVVT LLEEYATGPA VLTVALIEAV VVSWFYGITQ FCSDVKEMLG FSPGWFWRIC 
WVAISPLFLL FIICSFLMSP PQLRLFQYNY PHWSIILGYC IGTSSVICIP IYIIYRLIST 
PGTLKERIIK SITPETPTEI PCGDIRMNAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc6a4

Associated with

Other Information

Cloning and expression of the mouse serotonin transporter. PubMed ID: 9037532

Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. PubMed ID: 9073170

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Murine serotonin transporter: sequence and localization to chromosome 11. PubMed ID: 8507984

Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. PubMed ID: 9547354

Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. PubMed ID: 16803896

Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. PubMed ID: 17452640

Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. PubMed ID: 18317590

Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. PubMed ID: 20676059

Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. PubMed ID: 22572884

Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. PubMed ID: 25600870

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. PubMed ID: 27111230

The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. PubMed ID: 29038237