Genular: Defining Cellular Identity and Function

Details for: Elavl1

Gene ID: 15568

Symbol: Elavl1

Ensembl ID: ENSMUSG00000040028

Description: ELAV like RNA binding protein 1

Associated with

Hur (elavl1) binds and stabilizes mrna
(R-MMU-450520)
Metabolism of rna
(R-MMU-8953854)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
3'-utr-mediated mrna stabilization
(GO:0070935)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Double-stranded rna binding
(GO:0003725)
Endoplasmic reticulum
(GO:0005783)
Glutamatergic synapse
(GO:0098978)
Lncrna binding
(GO:0106222)
Mirna binding
(GO:0035198)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna 3'-utr binding
(GO:0003730)
Mrna binding
(GO:0003729)
Mrna destabilization
(GO:0061157)
Mrna stabilization
(GO:0048255)
Negative regulation of mirna-mediated gene silencing
(GO:0060965)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of superoxide anion generation
(GO:0032930)
Positive regulation of translation
(GO:0045727)
Post-transcriptional gene silencing
(GO:0016441)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Regulation of stem cell population maintenance
(GO:2000036)
Regulation of translation
(GO:0006417)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Sarcoplasm
(GO:0016528)

Other Information

Proteins

ELAV-like protein 1

Genular Protein ID: 46575379

Symbol: ELAV1_MOUSE

Name: ELAV-like protein 1

UniProtKB Accession Codes:

P70372 Q60745 Q78QY3

Database IDs:

Citations:

PubMed ID: 9763509

Title: ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.

PubMed ID: 9763509

DOI: 10.1242/jcs.111.21.3145

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7753842

Title: A conserved family of elav-like genes in vertebrates.

PubMed ID: 7753842

DOI: 10.1073/pnas.92.10.4557

PubMed ID: 12237300

Title: Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.

PubMed ID: 12237300

DOI: 10.1074/jbc.m206187200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21402775

Title: Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.

PubMed ID: 21402775

DOI: 10.1128/mcb.01424-10

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24394384

Title: N-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.

PubMed ID: 24394384

DOI: 10.1038/ncb2902

PubMed ID: 27616329

Title: Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.

PubMed ID: 27616329

DOI: 10.1016/j.bbalip.2016.09.006

Sequence Information:

Length: 326
Mass: 36169
Checksum: 74A98DEE5B921AF6
Sequence:

MSNGYEDHMA EDCRDDIGRT NLIVNYLPQN MTQEELRSLF SSIGEVESAK LIRDKVAGHS 
LGYGFVNYVT AKDAERAIST LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK 
DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT 
VKFAANPNQN KNMALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG ISGVNVPGNA 
SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM 
AIASLNGYRL GDKILQVSFK TNKSHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Elavl1

Associated with

Other Information

ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. PubMed ID: 9763509

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A conserved family of elav-like genes in vertebrates. PubMed ID: 7753842

Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. PubMed ID: 12237300

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation. PubMed ID: 21402775

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. PubMed ID: 24394384

Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. PubMed ID: 27616329