CYP2C19 | ENSG00000165841 | NCBI 1557

Details for: CYP2C19

Gene ID: 1557

Symbol: CYP2C19

Ensembl ID: ENSG00000165841

Description: cytochrome P450 family 2 subfamily C member 19

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-HSA-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-HSA-2142670)
Xenobiotics
(R-HSA-211981)
(r)-limonene 6-monooxygenase activity
(GO:0052741)
(s)-limonene 6-monooxygenase activity
(GO:0018675)
(s)-limonene 7-monooxygenase activity
(GO:0018676)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Omega-hydroxylase p450 pathway
(GO:0097267)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Oxygen binding
(GO:0019825)
Plasma membrane
(GO:0005886)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2C19

Genular Protein ID: 3604756082

Symbol: CP2CJ_HUMAN

Name: Cytochrome P450 2C19

UniProtKB Accession Codes:

P33261 P33259 Q8WZB1 Q8WZB2 Q9UCD4

Database IDs:

Citations:

PubMed ID: 2009263

Title: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

PubMed ID: 2009263

DOI: 10.1021/bi00227a012

PubMed ID: 8095407

Title:

PubMed ID: 8095407

DOI: 10.1021/bi00056a025

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 8215410

Title: Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation.

PubMed ID: 8215410

DOI: 10.1006/abbi.1993.1506

PubMed ID: 11950794

Title: Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

PubMed ID: 11950794

DOI: 10.1124/dmd.30.5.602

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 23959307

Title: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

PubMed ID: 23959307

DOI: 10.1128/aac.00843-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28378927

Title: Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

PubMed ID: 28378927

DOI: 10.1002/cpt.690

PubMed ID: 23118231

Title: Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19.

PubMed ID: 23118231

DOI: 10.1074/jbc.m112.424895

PubMed ID: 8195181

Title: The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

PubMed ID: 8195181

DOI: 10.1016/s0021-9258(17)40694-6

PubMed ID: 7969038

Title: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

PubMed ID: 7969038

PubMed ID: 9103550

Title: Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele.

PubMed ID: 9103550

PubMed ID: 9732415

Title: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.

PubMed ID: 9732415

PubMed ID: 10022751

Title: An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians.

PubMed ID: 10022751

DOI: 10.1097/00008571-199804000-00006

PubMed ID: 10411572

Title: A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.

PubMed ID: 10411572

PubMed ID: 12464799

Title: Identification and functional characterization of new potentially defective alleles of human CYP2C19.

PubMed ID: 12464799

DOI: 10.1097/00008571-200212000-00004

PubMed ID: 15499191

Title: A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation.

PubMed ID: 15499191

DOI: 10.2133/dmpk.19.236

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 16141610

Title: Genetic variations and haplotypes of CYP2C19 in a Japanese population.

PubMed ID: 16141610

DOI: 10.2133/dmpk.20.300

Sequence Information:

Length: 490
Mass: 55945
Checksum: B451BFFE9A009465
Sequence:

MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV SKSLTNLSKI 
YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF PLAERANRGF GIVFSNGKRW 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
IIFQKRFDYK DQQFLNLMEK LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM 
ESDILEKVKE HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE 
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRGHMPYTDA VVHEVQRYID 
LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE FPNPEMFDPR HFLDEGGNFK 
KSNYFMPFSA GKRICVGEGL ARMELFLFLT FILQNFNLKS LIDPKDLDTT PVVNGFASVP 
PFYQLCFIPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2C19

Associated with

Other Information

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. PubMed ID: 2009263

PubMed ID: 8095407

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation. PubMed ID: 8215410

Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. PubMed ID: 11950794

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. PubMed ID: 18577768

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. PubMed ID: 20972997

CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. PubMed ID: 23959307

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. PubMed ID: 28378927

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19. PubMed ID: 23118231

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. PubMed ID: 8195181

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. PubMed ID: 7969038

Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. PubMed ID: 9103550

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. PubMed ID: 9732415

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. PubMed ID: 10022751

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. PubMed ID: 10411572

Identification and functional characterization of new potentially defective alleles of human CYP2C19. PubMed ID: 12464799

A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation. PubMed ID: 15499191

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

Genetic variations and haplotypes of CYP2C19 in a Japanese population. PubMed ID: 16141610