Details for: CYP2C8

Gene ID: 1558

Symbol: CYP2C8

Ensembl ID: ENSG00000138115

Description: cytochrome P450 family 2 subfamily C member 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.9
    Marker Score: 15567
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.11
    Marker Score: 13559
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.04
    Marker Score: 2182
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.03
    Marker Score: 8755
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.43
    Marker Score: 442.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.11
    Marker Score: 2296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1947
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 690
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1
    Marker Score: 274
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 401.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 417
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 468
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1454
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 384
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 469
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.5
    Marker Score: 110
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7833
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 299
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.45
    Marker Score: 1815
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 144
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.37
    Marker Score: 3138
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.36
    Marker Score: 3385
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 20835
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.34
    Marker Score: 520
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 155
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.32
    Marker Score: 3001
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.3
    Marker Score: 1045
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.28
    Marker Score: 280
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.23
    Marker Score: 213
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.22
    Marker Score: 2286
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 81
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2
    Marker Score: 138
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.2
    Marker Score: 92
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 461
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 122
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.19
    Marker Score: 191
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.18
    Marker Score: 275
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.18
    Marker Score: 66.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.18
    Marker Score: 6484
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.17
    Marker Score: 641
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.15
    Marker Score: 3068
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 126
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 95.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.14
    Marker Score: 5299
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.13
    Marker Score: 1948
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 186
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.11
    Marker Score: 468
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.1
    Marker Score: 800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1
    Marker Score: 429
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 157.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1
    Marker Score: 408
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1
    Marker Score: 642
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 169.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 121
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.09
    Marker Score: 748
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 88

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Other Information

**Key characteristics** * The CYP2C8 gene is located on chromosome 15q21.1. * It is a member of the cytochrome P450 family of enzymes. * It is a bifunctional enzyme that can act as a cytochrome P450 enzyme or a cytochrome P450 reductase enzyme. * It is involved in the metabolism of a variety of compounds, including arachidonic acid, aspirin, and spearmine. **Pathways and functions** * The CYP2C8 enzyme is involved in the metabolism of arachidonic acid, an intermediate in the synthesis of eicosanoids. * It is also involved in the metabolism of aspirin, a nonsteroidal anti-inflammatory drug. * It is involved in the biosynthesis of spearmine, a compound that is used in the synthesis of vitamin K. **Clinical significance** * Mutations in the CYP2C8 gene have been linked to a number of liver diseases, including liver cirrhosis and hepatic failure. * CYP2C8 inhibitors are being investigated as a treatment for liver diseases. **Additional information** * The CYP2C8 gene is highly expressed in the liver. * It is a highly conserved gene, with a similar gene found in humans, mice, and rats. * The CYP2C8 enzyme is a highly important enzyme in the liver. It is involved in the metabolism of a variety of compounds that are involved in liver function, including arachidonic acid, aspirin, and spearmine.

Genular Protein ID: 293904082

Symbol: CP2C8_HUMAN

Name: CYPIIC8

UniProtKB Accession Codes:

P10632 A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 4 Rhea 56 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3500169

Title: Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.

PubMed ID: 3500169

DOI: 10.1016/s0021-9258(18)47697-1

PubMed ID: 3697070

Title: cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.

PubMed ID: 3697070

DOI: 10.1093/nar/15.23.10053

PubMed ID: 2009263

Title: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

PubMed ID: 2009263

DOI: 10.1021/bi00227a012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1707679

Title: Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region.

PubMed ID: 1707679

DOI: 10.1016/0167-4781(91)90138-c

PubMed ID: 7574697

Title: Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

PubMed ID: 7574697

DOI: 10.1006/abbi.1995.1438

PubMed ID: 3196692

Title: Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

PubMed ID: 3196692

DOI: 10.1021/bi00418a039

PubMed ID: 2729895

Title: Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.

PubMed ID: 2729895

DOI: 10.1111/j.1469-1809.1989.tb01119.x

PubMed ID: 2216732

Title: Sequence of a human liver cytochrome P-450 cDNA clone.

PubMed ID: 2216732

DOI: 10.1093/nar/18.18.5550

PubMed ID: 15365880

Title: A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin.

PubMed ID: 15365880

DOI: 10.1007/s10038-004-0188-6

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 15766564

Title: Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

PubMed ID: 15766564

DOI: 10.1016/j.bbrc.2005.02.103

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14676196

Title: Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.

PubMed ID: 14676196

DOI: 10.1074/jbc.m312516200

PubMed ID: 18413310

Title: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

PubMed ID: 18413310

DOI: 10.1074/jbc.m802180200

PubMed ID: 11668219

Title: Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

PubMed ID: 11668219

DOI: 10.1097/00008571-200110000-00006

PubMed ID: 12429347

Title: CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

PubMed ID: 12429347

DOI: 10.1016/s0006-2952(02)01354-0

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 26427316

Title: Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6alpha-hydroxylation and amodiaquine N-deethylation.

PubMed ID: 26427316

DOI: 10.1016/j.dmpk.2015.07.003

Sequence Information:

  • Length: 490
  • Mass: 55825
  • Checksum: E920EB2084F477E1
  • Sequence:
    • MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV 
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 
PSYQICFIPV

Genular Protein ID: 1774902649

Symbol: B7Z1F5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1F5 F5H7Q9

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 420
  • Mass: 47786
  • Checksum: E74FEC3C5A3453AF
  • Sequence:
    • MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW KEIRRFSLTT 
LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK 
DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE 
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE TTSTTLRYGL 
LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD LVPTGVPHAV 
TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA 
GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.