Details for: CYP2C8

Gene ID: 1558

Symbol: CYP2C8

Ensembl ID: ENSG00000138115

Description: cytochrome P450 family 2 subfamily C member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.5868
    Cell Significance Index: -2.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.1126
    Cell Significance Index: -2.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 6.3607
    Cell Significance Index: 107.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.0925
    Cell Significance Index: -2.5800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.7736
    Cell Significance Index: 6.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3056
    Cell Significance Index: 19.2700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.9917
    Cell Significance Index: 7.6200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9386
    Cell Significance Index: 5.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6433
    Cell Significance Index: 39.4400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6132
    Cell Significance Index: 6.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5414
    Cell Significance Index: 13.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5129
    Cell Significance Index: 11.2300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4497
    Cell Significance Index: 6.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3577
    Cell Significance Index: 9.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2727
    Cell Significance Index: 51.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2006
    Cell Significance Index: 12.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1875
    Cell Significance Index: 3.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1866
    Cell Significance Index: 0.5000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1768
    Cell Significance Index: 0.6200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1767
    Cell Significance Index: 1.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1737
    Cell Significance Index: 49.9900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1609
    Cell Significance Index: 1.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1559
    Cell Significance Index: 3.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1266
    Cell Significance Index: 25.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1254
    Cell Significance Index: 4.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1072
    Cell Significance Index: 4.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1043
    Cell Significance Index: 3.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0908
    Cell Significance Index: 9.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0592
    Cell Significance Index: 53.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0556
    Cell Significance Index: 19.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0488
    Cell Significance Index: 3.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0245
    Cell Significance Index: 0.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0221
    Cell Significance Index: 3.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0220
    Cell Significance Index: 2.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0170
    Cell Significance Index: 1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0151
    Cell Significance Index: 0.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0141
    Cell Significance Index: 0.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0131
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0090
    Cell Significance Index: 0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0079
    Cell Significance Index: 1.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0064
    Cell Significance Index: 0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0062
    Cell Significance Index: 0.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0046
    Cell Significance Index: 0.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 7.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0015
    Cell Significance Index: -0.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0030
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0117
    Cell Significance Index: -2.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0152
    Cell Significance Index: -1.8700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0159
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0217
    Cell Significance Index: -2.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0223
    Cell Significance Index: -1.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0228
    Cell Significance Index: -2.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0244
    Cell Significance Index: -0.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0249
    Cell Significance Index: -2.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0257
    Cell Significance Index: -1.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0259
    Cell Significance Index: -0.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0266
    Cell Significance Index: -0.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0296
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0322
    Cell Significance Index: -2.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0332
    Cell Significance Index: -0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0354
    Cell Significance Index: -2.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0366
    Cell Significance Index: -0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0370
    Cell Significance Index: -1.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0381
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0386
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0420
    Cell Significance Index: -1.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0436
    Cell Significance Index: -2.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0445
    Cell Significance Index: -2.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0453
    Cell Significance Index: -0.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0470
    Cell Significance Index: -0.9300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0479
    Cell Significance Index: -0.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0490
    Cell Significance Index: -1.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0494
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0535
    Cell Significance Index: -2.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0555
    Cell Significance Index: -1.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0597
    Cell Significance Index: -2.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0627
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0647
    Cell Significance Index: -1.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0649
    Cell Significance Index: -0.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP2C8 is a monooxygenase enzyme that utilizes reduced flavin as a cofactor to catalyze the oxidation of its substrates. The enzyme is membrane-bound and has been localized to various tissues, including the liver, colon, and kidney. CYP2C8 is highly expressed in the periportal and centrilobular regions of the liver, where it plays a key role in the metabolism of lipids and xenobiotics. One of the unique characteristics of CYP2C8 is its ability to catalyze the formation of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), which are important signaling molecules involved in various physiological processes, including inflammation and lipid metabolism. CYP2C8 also exhibits a high degree of substrate specificity, with a preference for fatty acids and arachidonic acid over other substrates. **Pathways and Functions** CYP2C8 is involved in several key metabolic pathways, including: 1. **Arachidonic acid epoxygenase activity**: CYP2C8 catalyzes the oxidation of arachidonic acid to form epoxyeicosatrienoic acids (EETs), which are important signaling molecules involved in inflammation and lipid metabolism. 2. **Fatty acid metabolism**: CYP2C8 is involved in the oxidation of various fatty acids, including long-chain fatty acids, which are important energy sources for the cell. 3. **Biosynthesis of specialized proresolving mediators (spms)**: CYP2C8 is involved in the synthesis of spms, which are important anti-inflammatory molecules involved in the resolution of inflammation. 4. **Xenobiotic metabolism**: CYP2C8 is involved in the metabolism of various xenobiotics, including drugs and environmental toxins. **Clinical Significance** CYP2C8 plays a critical role in the metabolism of various drugs, including: 1. **Warfarin**: CYP2C8 is involved in the metabolism of warfarin, a widely used anticoagulant. 2. **Clopidogrel**: CYP2C8 is involved in the metabolism of clopidogrel, a widely used antiplatelet agent. 3. **Aspirin**: CYP2C8 is involved in the metabolism of aspirin, a widely used anti-inflammatory agent. Variations in the CYP2C8 gene have been associated with an increased risk of bleeding and cardiovascular disease, highlighting the importance of this enzyme in clinical practice. Additionally, CYP2C8 has been implicated in various diseases, including cancer, inflammatory bowel disease, and atherosclerosis. In conclusion, CYP2C8 is a critical enzyme involved in the metabolism of various substrates, including drugs, hormones, and lipids. Its unique characteristics and substrate specificity make it an important target for therapeutic interventions and diagnostic testing. Further research is needed to fully understand the role of CYP2C8 in human health and disease.

Genular Protein ID: 293904082

Symbol: CP2C8_HUMAN

Name: CYPIIC8

UniProtKB Accession Codes:

P10632 A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 4 Rhea 56 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3500169

Title: Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.

PubMed ID: 3500169

DOI: 10.1016/s0021-9258(18)47697-1

PubMed ID: 3697070

Title: cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.

PubMed ID: 3697070

DOI: 10.1093/nar/15.23.10053

PubMed ID: 2009263

Title: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

PubMed ID: 2009263

DOI: 10.1021/bi00227a012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1707679

Title: Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region.

PubMed ID: 1707679

DOI: 10.1016/0167-4781(91)90138-c

PubMed ID: 7574697

Title: Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

PubMed ID: 7574697

DOI: 10.1006/abbi.1995.1438

PubMed ID: 3196692

Title: Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

PubMed ID: 3196692

DOI: 10.1021/bi00418a039

PubMed ID: 2729895

Title: Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.

PubMed ID: 2729895

DOI: 10.1111/j.1469-1809.1989.tb01119.x

PubMed ID: 2216732

Title: Sequence of a human liver cytochrome P-450 cDNA clone.

PubMed ID: 2216732

DOI: 10.1093/nar/18.18.5550

PubMed ID: 15365880

Title: A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin.

PubMed ID: 15365880

DOI: 10.1007/s10038-004-0188-6

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 15766564

Title: Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

PubMed ID: 15766564

DOI: 10.1016/j.bbrc.2005.02.103

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14676196

Title: Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.

PubMed ID: 14676196

DOI: 10.1074/jbc.m312516200

PubMed ID: 18413310

Title: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

PubMed ID: 18413310

DOI: 10.1074/jbc.m802180200

PubMed ID: 11668219

Title: Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

PubMed ID: 11668219

DOI: 10.1097/00008571-200110000-00006

PubMed ID: 12429347

Title: CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

PubMed ID: 12429347

DOI: 10.1016/s0006-2952(02)01354-0

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 26427316

Title: Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6alpha-hydroxylation and amodiaquine N-deethylation.

PubMed ID: 26427316

DOI: 10.1016/j.dmpk.2015.07.003

Sequence Information:

  • Length: 490
  • Mass: 55825
  • Checksum: E920EB2084F477E1
  • Sequence:
    • MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV 
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 
PSYQICFIPV

Genular Protein ID: 1774902649

Symbol: B7Z1F5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1F5 F5H7Q9

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 420
  • Mass: 47786
  • Checksum: E74FEC3C5A3453AF
  • Sequence:
    • MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW KEIRRFSLTT 
LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK 
DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE 
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE TTSTTLRYGL 
LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD LVPTGVPHAV 
TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA 
GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.