Genular: Defining Cellular Identity and Function

Details for: Hyal1

Gene ID: 15586

Symbol: Hyal1

Ensembl ID: ENSMUSG00000010051

Description: hyaluronoglucosaminidase 1

Associated with

Chondroitin sulfate/dermatan sulfate metabolism
(R-MMU-1793185)
Cs/ds degradation
(R-MMU-2024101)
Glycosaminoglycan metabolism
(R-MMU-1630316)
Hyaluronan metabolism
(R-MMU-2142845)
Hyaluronan uptake and degradation
(R-MMU-2160916)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Carbohydrate metabolic process
(GO:0005975)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to ph
(GO:0071467)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cellular response to uv-b
(GO:0071493)
Chondroitin hydrolase activity
(GO:0052757)
Chondroitin sulfate catabolic process
(GO:0030207)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Embryonic skeletal joint morphogenesis
(GO:0060272)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hyaluranon cable
(GO:0036117)
Hyaluronan biosynthetic process
(GO:0030213)
Hyaluronan catabolic process
(GO:0030214)
Hyaluronan metabolic process
(GO:0030212)
Hyaluronan synthase activity
(GO:0050501)
Hyalurononglucosaminidase activity
(GO:0004415)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Inflammatory response
(GO:0006954)
Lysosome
(GO:0005764)
Metabolic process
(GO:0008152)
Negative regulation of cell growth
(GO:0030308)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of growth
(GO:0045927)
Positive regulation of hyaluranon cable assembly
(GO:1900106)
Response to antibiotic
(GO:0046677)
Response to reactive oxygen species
(GO:0000302)
Response to virus
(GO:0009615)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

Hyaluronidase-1

Genular Protein ID: 2139559201

Symbol: HYAL1_MOUSE

Name: Hyaluronidase-1

UniProtKB Accession Codes:

Q91ZJ9 B1AV90 O70229 Q8CE62 Q8QZX3 Q8VBW7 Q8VDK0

Database IDs:

Citations:

PubMed ID: 9503017

Title: The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus.

PubMed ID: 9503017

DOI: 10.1006/geno.1997.5158

PubMed ID: 11960552

Title: Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts.

PubMed ID: 11960552

DOI: 10.1186/1471-2121-3-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11929860

Title: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.

PubMed ID: 11929860

DOI: 10.1074/jbc.m108991200

Sequence Information:

Length: 462
Mass: 52109
Checksum: DCE7339D7E0BCB9D
Sequence:

MLGLTQHAQK VWRMKPFSPE VSPGSSPATA GHLLRISTLF LTLLELAQVC RGSVVSNRPF 
ITVWNGDTHW CLTEYGVDVD VSVFDVVANK EQSFQGSNMT IFYREELGTY PYYTPTGEPV 
FGGLPQNASL VTHLAHTFQD IKAAMPEPDF SGLAVIDWEA WRPRWAFNWD SKDIYRQRSM 
ELVQAEHPDW PETLVEAAAK NQFQEAAEAW MAGTLQLGQV LRPRGLWGYY GFPDCYNNDF 
LSLNYTGQCP VFVRDQNDQL GWLWNQSYAL YPSIYLPAAL MGTEKSQMYV RHRVQEALRV 
AIVSRDPHVP VMPYVQIFYE MTDYLLPLEE LEHSLGESAA QGVAGAVLWL SSDKTSTKES 
CQAIKAYMDS TLGPFIVNVT SAALLCSEAL CSGHGRCVRH PSYPEALLTL NPASFSIELT 
HDGRPPSLKG TLSLKDRAQM AMKFRCRCYR GWRGKWCDKR GM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hyal1

Associated with

Other Information

The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. PubMed ID: 9503017

Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts. PubMed ID: 11960552

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334