Genular: Defining Cellular Identity and Function

Details for: Hyal2

Gene ID: 15587

Symbol: Hyal2

Ensembl ID: ENSMUSG00000010047

Description: hyaluronoglucosaminidase 2

Associated with

Glycosaminoglycan metabolism
(R-MMU-1630316)
Hyaluronan metabolism
(R-MMU-2142845)
Hyaluronan uptake and degradation
(R-MMU-2160916)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Apical plasma membrane
(GO:0016324)
Carbohydrate metabolic process
(GO:0005975)
Cell surface
(GO:0009986)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to uv-b
(GO:0071493)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Endocytic vesicle
(GO:0030139)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Fusion of virus membrane with host plasma membrane
(GO:0019064)
Glycosaminoglycan catabolic process
(GO:0006027)
Golgi membrane
(GO:0000139)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hyaluronan catabolic process
(GO:0030214)
Hyaluronic acid binding
(GO:0005540)
Hyaluronoglucuronidase activity
(GO:0033906)
Hyalurononglucosaminidase activity
(GO:0004415)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metabolic process
(GO:0008152)
Microvillus
(GO:0005902)
Monocyte activation
(GO:0042117)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Receptor signaling protein tyrosine kinase inhibitor activity
(GO:0030294)
Receptor tyrosine kinase binding
(GO:0030971)
Response to reactive oxygen species
(GO:0000302)
Response to virus
(GO:0009615)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Side of membrane
(GO:0098552)
Skeletal system morphogenesis
(GO:0048705)
Symbiont entry into host cell
(GO:0046718)
Transcription coactivator activity
(GO:0003713)
Transforming growth factor beta binding
(GO:0050431)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

Hyaluronidase-2

Genular Protein ID: 1162817258

Symbol: HYAL2_MOUSE

Name: Hyaluronidase-2

UniProtKB Accession Codes:

O35632 O35631 Q99MS9 Q99MT0

Database IDs:

Citations:

PubMed ID: 9790770

Title: Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase.

PubMed ID: 9790770

DOI: 10.1006/geno.1998.5472

PubMed ID: 11296287

Title: Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.

PubMed ID: 11296287

DOI: 10.1073/pnas.071572898

PubMed ID: 11960552

Title: Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts.

PubMed ID: 11960552

DOI: 10.1186/1471-2121-3-8

PubMed ID: 11731268

Title: Hyal2 -- less active, but more versatile?

PubMed ID: 11731268

DOI: 10.1016/s0945-053x(01)00170-6

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

Sequence Information:

Length: 473
Mass: 53618
Checksum: DD433C9FFCF8147C
Sequence:

MRAGLGPIIT LALVLEVAWA GELKPTAPPI FTGRPFVVAW NVPTQECAPR HKVPLDLRAF 
DVKATPNEGF FNQNITTFYY DRLGLYPRFD AAGTSVHGGV PQNGSLCAHL PMLKESVERY 
IQTQEPGGLA VIDWEEWRPV WVRNWQEKDV YRQSSRQLVA SRHPDWPSDR VMKQAQYEFE 
FAARQFMLNT LRYVKAVRPQ HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW 
LWAESTALFP SVYLDETLAS SVHSRNFVSF RVREALRVAH THHANHALPV YVFTRPTYTR 
GLTGLSQVDL ISTIGESAAL GSAGVIFWGD SEDASSMETC QYLKNYLTQL LVPYIVNVSW 
ATQYCSWTQC HGHGRCVRRN PSANTFLHLN ASSFRLVPGH TPSEPQLRPE GQLSEADLNY 
LQKHFRCQCY LGWGGEQCQR NYKGAAGNAS RAWAGSHLTS LLGLVAVALT WTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hyal2

Associated with

Other Information

Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. PubMed ID: 9790770

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. PubMed ID: 11296287

Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts. PubMed ID: 11960552