CYP2C9 | ENSG00000138109 | NCBI 1559

Details for: CYP2C9

Gene ID: 1559

Symbol: CYP2C9

Ensembl ID: ENSG00000138109

Description: cytochrome P450 family 2 subfamily C member 9

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-HSA-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-HSA-2142670)
Xenobiotics
(R-HSA-211981)
(r)-limonene 6-monooxygenase activity
(GO:0052741)
(s)-limonene 6-monooxygenase activity
(GO:0018675)
(s)-limonene 7-monooxygenase activity
(GO:0018676)
Amide metabolic process
(GO:0043603)
Arachidonic acid 11,12-epoxygenase activity
(GO:0008405)
Arachidonic acid 14,15-epoxygenase activity
(GO:0008404)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Caffeine oxidase activity
(GO:0034875)
Cholesterol metabolic process
(GO:0008203)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Epoxygenase p450 pathway
(GO:0019373)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Icosanoid biosynthetic process
(GO:0046456)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Monocarboxylic acid metabolic process
(GO:0032787)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Omega-hydroxylase p450 pathway
(GO:0097267)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Plasma membrane
(GO:0005886)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Urea metabolic process
(GO:0019627)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

(R)-limonene 6-monooxygenase

Genular Protein ID: 1904467796

Symbol: CP2C9_HUMAN

Name: (R)-limonene 6-monooxygenase

UniProtKB Accession Codes:

P11712 P11713 Q16756 Q16872 Q5VX92 Q6IRV8 Q8WW80

Database IDs:

Citations:

PubMed ID: 2827463

Title: Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.

PubMed ID: 2827463

PubMed ID: 3697070

Title: cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.

PubMed ID: 3697070

DOI: 10.1093/nar/15.23.10053

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2963808

Title: Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form.

PubMed ID: 2963808

DOI: 10.1093/oxfordjournals.jbchem.a122145

PubMed ID: 3032244

Title: Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase.

PubMed ID: 3032244

DOI: 10.1021/bi00378a016

PubMed ID: 3196692

Title: Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

PubMed ID: 3196692

DOI: 10.1021/bi00418a039

PubMed ID: 1445376

Title: Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity.

PubMed ID: 1445376

PubMed ID: 3079764

Title: Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

PubMed ID: 3079764

DOI: 10.1016/s0021-9258(17)36183-5

PubMed ID: 3243766

Title: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.

PubMed ID: 3243766

DOI: 10.1093/oxfordjournals.jbchem.a122582

PubMed ID: 1857342

Title: Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

PubMed ID: 1857342

PubMed ID: 8809086

Title: Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

PubMed ID: 8809086

DOI: 10.1006/abbi.1996.0414

PubMed ID: 8215449

Title: Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity.

PubMed ID: 8215449

DOI: 10.1006/abbi.1993.1536

PubMed ID: 7574697

Title: Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

PubMed ID: 7574697

DOI: 10.1006/abbi.1995.1438

PubMed ID: 9866708

Title: Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.

PubMed ID: 9866708

DOI: 10.1006/abio.1998.2897

PubMed ID: 9435160

Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

PubMed ID: 9435160

PubMed ID: 11950794

Title: Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

PubMed ID: 11950794

DOI: 10.1124/dmd.30.5.602

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15766564

Title: Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

PubMed ID: 15766564

DOI: 10.1016/j.bbrc.2005.02.103

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12861225

Title: Crystal structure of human cytochrome P450 2C9 with bound warfarin.

PubMed ID: 12861225

DOI: 10.1038/nature01862

PubMed ID: 8946475

Title: Genetic analysis of the human cytochrome P450 CYP2C9 locus.

PubMed ID: 8946475

DOI: 10.1097/00008571-199610000-00007

PubMed ID: 9110362

Title: Allelic and functional variability of cytochrome P4502C9.

PubMed ID: 9110362

DOI: 10.1097/00008571-199702000-00007

PubMed ID: 10739176

Title: Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.

PubMed ID: 10739176

DOI: 10.1097/00008571-200002000-00011

PubMed ID: 11455026

Title: Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans.

PubMed ID: 11455026

DOI: 10.1124/mol.60.2.382

PubMed ID: 11926893

Title: Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.

PubMed ID: 11926893

DOI: 10.1001/jama.287.13.1690

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 21451434

Title: Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient.

PubMed ID: 21451434

DOI: 10.1097/fpc.0b013e328344c340

PubMed ID: 23582453

Title: Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity.

PubMed ID: 23582453

DOI: 10.1016/j.thromres.2013.03.019

PubMed ID: 24956244

Title: Warfarin dose requirements in a patient with the CYP2C9*14 allele.

PubMed ID: 24956244

DOI: 10.2217/pgs.14.47

PubMed ID: 25994031

Title: Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59.

PubMed ID: 25994031

DOI: 10.1124/dmd.115.063412

Sequence Information:

Length: 490
Mass: 55628
Checksum: 4FDFC395303A4E3E
Sequence:

MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI SKSLTNLSKV 
YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF PLAERANRGF GIVFSNGKKW 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
IIFHKRFDYK DQQFLNLMEK LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM 
KSYILEKVKE HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE 
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA VVHEVQRYID 
LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE FPNPEMFDPH HFLDEGGNFK 
KSKYFMPFSA GKRICVGEAL AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP 
PFYQLCFIPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2C9

Associated with

Other Information

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10. PubMed ID: 2827463

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. PubMed ID: 3697070

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. PubMed ID: 2963808

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. PubMed ID: 3032244

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. PubMed ID: 3196692

Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity. PubMed ID: 1445376

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. PubMed ID: 3079764

Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization. PubMed ID: 3243766

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. PubMed ID: 1857342

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. PubMed ID: 8809086

Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity. PubMed ID: 8215449

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. PubMed ID: 7574697

Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS. PubMed ID: 9866708

Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. PubMed ID: 9435160

Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. PubMed ID: 11950794

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. PubMed ID: 15766564

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576

Cholesterol 25-hydroxylation activity of CYP3A. PubMed ID: 21576599

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of human cytochrome P450 2C9 with bound warfarin. PubMed ID: 12861225

Genetic analysis of the human cytochrome P450 CYP2C9 locus. PubMed ID: 8946475

Allelic and functional variability of cytochrome P4502C9. PubMed ID: 9110362

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus. PubMed ID: 10739176

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. PubMed ID: 11455026

Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. PubMed ID: 11926893

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient. PubMed ID: 21451434

Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity. PubMed ID: 23582453

Warfarin dose requirements in a patient with the CYP2C9*14 allele. PubMed ID: 24956244

Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59. PubMed ID: 25994031