Details for: CYP2C9

Gene ID: 1559

Symbol: CYP2C9

Ensembl ID: ENSG00000138109

Description: cytochrome P450 family 2 subfamily C member 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.68
    Marker Score: 14,415
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.09
    Marker Score: 13,431
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.98
    Marker Score: 8,560
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.53
    Marker Score: 1,634
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.02
    Marker Score: 316
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1,850
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1,323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.79
    Marker Score: 299
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,515
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.72
    Marker Score: 198
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1,437
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.69
    Marker Score: 991
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.67
    Marker Score: 670
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2,687
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.64
    Marker Score: 158
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 362
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.62
    Marker Score: 151
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.62
    Marker Score: 325
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 352
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 939
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.57
    Marker Score: 568
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1,346
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.54
    Marker Score: 752
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.51
    Marker Score: 780
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.49
    Marker Score: 2,349
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6,514
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.38
    Marker Score: 2,419
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.36
    Marker Score: 244
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.32
    Marker Score: 118
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 148
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 113
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.27
    Marker Score: 170
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 516
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.18
    Marker Score: 191
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.15
    Marker Score: 125
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.14
    Marker Score: 492
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.13
    Marker Score: 399
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.11
    Marker Score: 260
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1
    Marker Score: 227
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.09
    Marker Score: 150
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.07
    Marker Score: 170
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 423
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.06
    Marker Score: 175
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 20

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP2C9 is a monooxygenase enzyme that belongs to the cytochrome P450 family. It has a molecular weight of approximately 50 kDa and is composed of 500 amino acids. The enzyme is characterized by its ability to catalyze the incorporation of molecular oxygen to form reactive metabolites, which are then further metabolized or excreted. CYP2C9 is specifically involved in the oxidation of arachidonic acid, which is a key step in the synthesis of eicosanoids, including prostaglandins and leukotrienes. The enzyme is also involved in the metabolism of steroids, including the oxidation of androgens and estrogens. **Pathways and Functions** CYP2C9 is involved in a range of metabolic pathways, including: 1. **Arachidonic acid metabolism**: CYP2C9 is involved in the oxidation of arachidonic acid, which is a key step in the synthesis of eicosanoids. 2. **Steroid metabolism**: CYP2C9 is involved in the oxidation of androgens and estrogens, which can affect reproductive and metabolic processes. 3. **Xenobiotic metabolism**: CYP2C9 is involved in the detoxification of xenobiotics, including environmental pollutants and certain medications. 4. **Lipid metabolism**: CYP2C9 is involved in the metabolism of lipids, including the oxidation of fatty acids. 5. **Aromatase activity**: CYP2C9 is involved in the metabolism of aromatase, which is a key enzyme in the synthesis of estrogens. **Clinical Significance** Variations in the CYP2C9 gene have been associated with altered metabolic activity, which can have significant implications for the efficacy and safety of certain medications. For example: 1. **Warfarin metabolism**: CYP2C9 is involved in the metabolism of warfarin, a blood thinner that is used to prevent thrombosis. Variations in the CYP2C9 gene can affect the metabolism of warfarin, leading to either increased or decreased anticoagulant activity. 2. **Anti-inflammatory medications**: CYP2C9 is involved in the metabolism of certain anti-inflammatory medications, including ibuprofen and naproxen. Variations in the CYP2C9 gene can affect the efficacy and safety of these medications. 3. **Cancer treatment**: CYP2C9 is involved in the metabolism of certain cancer treatments, including cyclophosphamide and doxorubicin. Variations in the CYP2C9 gene can affect the efficacy and safety of these treatments. In conclusion, CYP2C9 is a critical enzyme involved in a range of metabolic pathways, including the oxidation of arachidonic acid, the metabolism of steroids, and the detoxification of xenobiotics. Variations in the CYP2C9 gene can have significant implications for the efficacy and safety of certain medications, highlighting the importance of personalized medicine and genetic testing in clinical practice.

Genular Protein ID: 1904467796

Symbol: CP2C9_HUMAN

Name: (R)-limonene 6-monooxygenase

UniProtKB Accession Codes:

P11712 P11713 Q16756 Q16872 Q5VX92 Q6IRV8 Q8WW80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 4 EMBL 14 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 13 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 100 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2827463

Title: Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.

PubMed ID: 2827463

PubMed ID: 3697070

Title: cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.

PubMed ID: 3697070

DOI: 10.1093/nar/15.23.10053

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2963808

Title: Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form.

PubMed ID: 2963808

DOI: 10.1093/oxfordjournals.jbchem.a122145

PubMed ID: 3032244

Title: Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase.

PubMed ID: 3032244

DOI: 10.1021/bi00378a016

PubMed ID: 3196692

Title: Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

PubMed ID: 3196692

DOI: 10.1021/bi00418a039

PubMed ID: 1445376

Title: Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity.

PubMed ID: 1445376

PubMed ID: 3079764

Title: Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

PubMed ID: 3079764

DOI: 10.1016/s0021-9258(17)36183-5

PubMed ID: 3243766

Title: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.

PubMed ID: 3243766

DOI: 10.1093/oxfordjournals.jbchem.a122582

PubMed ID: 1857342

Title: Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

PubMed ID: 1857342

PubMed ID: 8809086

Title: Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

PubMed ID: 8809086

DOI: 10.1006/abbi.1996.0414

PubMed ID: 8215449

Title: Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity.

PubMed ID: 8215449

DOI: 10.1006/abbi.1993.1536

PubMed ID: 7574697

Title: Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

PubMed ID: 7574697

DOI: 10.1006/abbi.1995.1438

PubMed ID: 9866708

Title: Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.

PubMed ID: 9866708

DOI: 10.1006/abio.1998.2897

PubMed ID: 9435160

Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

PubMed ID: 9435160

PubMed ID: 11950794

Title: Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

PubMed ID: 11950794

DOI: 10.1124/dmd.30.5.602

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15766564

Title: Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

PubMed ID: 15766564

DOI: 10.1016/j.bbrc.2005.02.103

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12861225

Title: Crystal structure of human cytochrome P450 2C9 with bound warfarin.

PubMed ID: 12861225

DOI: 10.1038/nature01862

PubMed ID: 8946475

Title: Genetic analysis of the human cytochrome P450 CYP2C9 locus.

PubMed ID: 8946475

DOI: 10.1097/00008571-199610000-00007

PubMed ID: 9110362

Title: Allelic and functional variability of cytochrome P4502C9.

PubMed ID: 9110362

DOI: 10.1097/00008571-199702000-00007

PubMed ID: 10739176

Title: Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.

PubMed ID: 10739176

DOI: 10.1097/00008571-200002000-00011

PubMed ID: 11455026

Title: Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans.

PubMed ID: 11455026

DOI: 10.1124/mol.60.2.382

PubMed ID: 11926893

Title: Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.

PubMed ID: 11926893

DOI: 10.1001/jama.287.13.1690

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 21451434

Title: Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient.

PubMed ID: 21451434

DOI: 10.1097/fpc.0b013e328344c340

PubMed ID: 23582453

Title: Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity.

PubMed ID: 23582453

DOI: 10.1016/j.thromres.2013.03.019

PubMed ID: 24956244

Title: Warfarin dose requirements in a patient with the CYP2C9*14 allele.

PubMed ID: 24956244

DOI: 10.2217/pgs.14.47

PubMed ID: 25994031

Title: Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59.

PubMed ID: 25994031

DOI: 10.1124/dmd.115.063412

Sequence Information:

  • Length: 490
  • Mass: 55628
  • Checksum: 4FDFC395303A4E3E
  • Sequence:
    • MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI SKSLTNLSKV 
YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF PLAERANRGF GIVFSNGKKW 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS 
IIFHKRFDYK DQQFLNLMEK LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM 
KSYILEKVKE HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE 
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA VVHEVQRYID 
LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE FPNPEMFDPH HFLDEGGNFK 
KSKYFMPFSA GKRICVGEAL AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP 
PFYQLCFIPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.