Details for: GRK2

Gene ID: 156

Symbol: GRK2

Ensembl ID: ENSG00000173020

Description: G protein-coupled receptor kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.02
    Marker Score: 2132
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.42
    Marker Score: 10071
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.27
    Marker Score: 127085
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.04
    Marker Score: 20710
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.02
    Marker Score: 1715
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.89
    Marker Score: 4698.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.76
    Marker Score: 2121
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.7
    Marker Score: 1673
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.67
    Marker Score: 3257
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.59
    Marker Score: 959
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.56
    Marker Score: 672
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.55
    Marker Score: 1447
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.51
    Marker Score: 536
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.42
    Marker Score: 945
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.41
    Marker Score: 3965
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.4
    Marker Score: 1403
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.4
    Marker Score: 16224
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.39
    Marker Score: 845
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.38
    Marker Score: 1385
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.37
    Marker Score: 1156
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.37
    Marker Score: 934
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.36
    Marker Score: 422
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.36
    Marker Score: 469
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.31
    Marker Score: 3153
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.3
    Marker Score: 1482
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.28
    Marker Score: 638
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.26
    Marker Score: 1570
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.25
    Marker Score: 612.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.24
    Marker Score: 428
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.23
    Marker Score: 1325
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.22
    Marker Score: 307
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.21
    Marker Score: 398
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.2
    Marker Score: 817
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.17
    Marker Score: 3180.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.17
    Marker Score: 355
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.12
    Marker Score: 3333
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.11
    Marker Score: 3074
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1
    Marker Score: 9672
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.07
    Marker Score: 1022
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 343
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2109
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1519
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.01
    Marker Score: 643
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1
    Marker Score: 1827
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1
    Marker Score: 495
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71639
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4053
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.99
    Marker Score: 959.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47863
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.98
    Marker Score: 343
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.98
    Marker Score: 8422
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.98
    Marker Score: 422
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.97
    Marker Score: 593
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.97
    Marker Score: 10023
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 580
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.96
    Marker Score: 538
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.95
    Marker Score: 747
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.94
    Marker Score: 423
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.94
    Marker Score: 1109.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.94
    Marker Score: 1641.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2386
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.94
    Marker Score: 24004
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.94
    Marker Score: 1041
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.93
    Marker Score: 57379
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.93
    Marker Score: 462
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.93
    Marker Score: 2919.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.92
    Marker Score: 1642
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.92
    Marker Score: 992
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.91
    Marker Score: 384
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.91
    Marker Score: 689
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.9
    Marker Score: 202
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1903
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2685
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.88
    Marker Score: 358
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4982
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.87
    Marker Score: 8640
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.87
    Marker Score: 8242
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.87
    Marker Score: 4004.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.86
    Marker Score: 630
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13257
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.85
    Marker Score: 1307
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 886
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.84
    Marker Score: 201
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.84
    Marker Score: 914
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.84
    Marker Score: 44357
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.83
    Marker Score: 479
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.83
    Marker Score: 608
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.82
    Marker Score: 320
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1336
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.82
    Marker Score: 400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.81
    Marker Score: 909
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.81
    Marker Score: 477
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.81
    Marker Score: 215
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 447

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Other Information

**Key characteristics** * Gene name: GRK2 * Ensembl ID: ENSG00000173020 * Protein name: ARBK1_HUMAN * Protein type: Protein kinase * Cellular location: Cytoplasm **Pathways and functions** * Activation of Smo: GRK2 is a key regulator of the Smo pathway, which is involved in the regulation of T cell activation. * Calcium-dependent events: GRK2 is also involved in calcium-dependent events, which are a second wave of signaling that is triggered by the binding of calcium ions to certain receptors. * Cam pathway: GRK2 is a key regulator of the Cam pathway, which is involved in the regulation of B cell activation. **Clinical significance** GRK2 is a potential therapeutic target for a variety of diseases, including cancer and autoimmune disorders. For example, GRK2 is overexpressed in many types of cancer cells, and inhibitors of GRK2 have been shown to be effective in inhibiting cancer cell growth. **Additional information** * GRK2 is a member of the G protein-coupled receptor kinase family of proteins. * GRK2 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * GRK2 is a multi-functional protein that can interact with a variety of different proteins.

Genular Protein ID: 1193992578

Symbol: ARBK1_HUMAN

Name: Beta-adrenergic receptor kinase 1

UniProtKB Accession Codes:

P25098 B0ZBE1 Q13837 Q6GTT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2037065

Title: cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.

PubMed ID: 2037065

DOI: 10.1016/0014-5793(91)80568-n

PubMed ID: 1339451

Title: High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.

PubMed ID: 1339451

DOI: 10.1016/s0021-9258(19)50511-7

PubMed ID: 8195124

Title: Structure of the human gene encoding the beta-adrenergic receptor kinase.

PubMed ID: 8195124

DOI: 10.1016/s0021-9258(17)36554-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501202

Title: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.

PubMed ID: 9501202

DOI: 10.1073/pnas.95.6.2985

PubMed ID: 10085131

Title: Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

PubMed ID: 10085131

DOI: 10.1074/jbc.274.13.8875

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19715378

Title: Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.

PubMed ID: 19715378

DOI: 10.1021/bi900408g

PubMed ID: 19306925

Title: Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.

PubMed ID: 19306925

DOI: 10.1016/j.cellsig.2009.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30284927

Title: Airway smooth muscle photorelaxation via opsin receptor activation.

PubMed ID: 30284927

DOI: 10.1152/ajplung.00135.2018

PubMed ID: 9446593

Title: The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits.

PubMed ID: 9446593

DOI: 10.1074/jbc.273.5.2835

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 689
  • Mass: 79574
  • Checksum: 4DB68F62841AFA7D
  • Sequence:
    • MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR GEVTFEKIFS 
QKLGYLLFRD FCLNHLEEAR PLVEFYEEIK KYEKLETEEE RVARSREIFD SYIMKELLAC 
SHPFSKSATE HVQGHLGKKQ VPPDLFQPYI EEICQNLRGD VFQKFIESDK FTRFCQWKNV 
ELNIHLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTMA VELPDSFSPE 
LRSLLEGLLQ RDVNRRLGCL GRGAQEVKES PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA 
DAFDIGSFDE EDTKGIKLLD SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK 
KAKNKQLGHE EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEGEAPQSL 
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF ILQCDSDPEL VQWKKELRDA YREAQQLVQR 
VPKMKNKPRS PVVELSKVPL VQRGSANGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.