GRK2 | ENSG00000173020 | NCBI 156

Details for: GRK2

Gene ID: 156

Symbol: GRK2

Ensembl ID: ENSG00000173020

Description: G protein-coupled receptor kinase 2

Associated with

Activation of smo
(R-HSA-5635838)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Dag and ip3 signaling
(R-HSA-1489509)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Hedgehog 'on' state
(R-HSA-5632684)
Intracellular signaling by second messengers
(R-HSA-9006925)
Membrane trafficking
(R-HSA-199991)
Opioid signalling
(R-HSA-111885)
Plc beta mediated events
(R-HSA-112043)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Alpha-2a adrenergic receptor binding
(GO:0031694)
Atp binding
(GO:0005524)
Beta-adrenergic receptor kinase activity
(GO:0047696)
Cardiac muscle contraction
(GO:0060048)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Desensitization of g protein-coupled receptor signaling pathway
(GO:0002029)
Edg-2 lysophosphatidic acid receptor binding
(GO:0031755)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor kinase activity
(GO:0004703)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Membrane
(GO:0016020)
Negative regulation of relaxation of smooth muscle
(GO:1901081)
Negative regulation of striated muscle contraction
(GO:0045988)
Negative regulation of the force of heart contraction by chemical signal
(GO:0003108)
Peptidyl-serine phosphorylation
(GO:0018105)
Plasma membrane
(GO:0005886)
Positive regulation of catecholamine secretion
(GO:0033605)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Receptor internalization
(GO:0031623)
Regulation of the force of heart contraction
(GO:0002026)
Symbiont entry into host cell
(GO:0046718)
Tachykinin receptor signaling pathway
(GO:0007217)
Viral genome replication
(GO:0019079)

Other Information

Proteins

Beta-adrenergic receptor kinase 1

Genular Protein ID: 1193992578

Symbol: ARBK1_HUMAN

Name: Beta-adrenergic receptor kinase 1

UniProtKB Accession Codes:

P25098 B0ZBE1 Q13837 Q6GTT3

Database IDs:

Citations:

PubMed ID: 2037065

Title: cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.

PubMed ID: 2037065

DOI: 10.1016/0014-5793(91)80568-n

PubMed ID: 1339451

Title: High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.

PubMed ID: 1339451

DOI: 10.1016/s0021-9258(19)50511-7

PubMed ID: 8195124

Title: Structure of the human gene encoding the beta-adrenergic receptor kinase.

PubMed ID: 8195124

DOI: 10.1016/s0021-9258(17)36554-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501202

Title: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.

PubMed ID: 9501202

DOI: 10.1073/pnas.95.6.2985

PubMed ID: 10085131

Title: Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

PubMed ID: 10085131

DOI: 10.1074/jbc.274.13.8875

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19715378

Title: Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.

PubMed ID: 19715378

DOI: 10.1021/bi900408g

PubMed ID: 19306925

Title: Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.

PubMed ID: 19306925

DOI: 10.1016/j.cellsig.2009.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30284927

Title: Airway smooth muscle photorelaxation via opsin receptor activation.

PubMed ID: 30284927

DOI: 10.1152/ajplung.00135.2018

PubMed ID: 9446593

Title: The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits.

PubMed ID: 9446593

DOI: 10.1074/jbc.273.5.2835

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 689
Mass: 79574
Checksum: 4DB68F62841AFA7D
Sequence:

MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR GEVTFEKIFS 
QKLGYLLFRD FCLNHLEEAR PLVEFYEEIK KYEKLETEEE RVARSREIFD SYIMKELLAC 
SHPFSKSATE HVQGHLGKKQ VPPDLFQPYI EEICQNLRGD VFQKFIESDK FTRFCQWKNV 
ELNIHLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTMA VELPDSFSPE 
LRSLLEGLLQ RDVNRRLGCL GRGAQEVKES PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA 
DAFDIGSFDE EDTKGIKLLD SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK 
KAKNKQLGHE EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEGEAPQSL 
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF ILQCDSDPEL VQWKKELRDA YREAQQLVQR 
VPKMKNKPRS PVVELSKVPL VQRGSANGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRK2

Associated with

Other Information

cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. PubMed ID: 2037065

High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. PubMed ID: 1339451

Structure of the human gene encoding the beta-adrenergic receptor kinase. PubMed ID: 8195124

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. PubMed ID: 9501202

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. PubMed ID: 10085131

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. PubMed ID: 19715378

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. PubMed ID: 19306925

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Airway smooth muscle photorelaxation via opsin receptor activation. PubMed ID: 30284927

The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. PubMed ID: 9446593

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846