Details for: CYP2C18

Gene ID: 1562

Symbol: CYP2C18

Ensembl ID: ENSG00000108242

Description: cytochrome P450 family 2 subfamily C member 18

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.14
    Marker Score: 1786
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.46
    Marker Score: 9284
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1552
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5274
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7293
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 797
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.79
    Marker Score: 3804
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1430
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.75
    Marker Score: 186
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.72
    Marker Score: 174
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7
    Marker Score: 5455
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 941
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1191
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.57
    Marker Score: 885
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.54
    Marker Score: 537
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.48
    Marker Score: 140
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.47
    Marker Score: 234
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.46
    Marker Score: 946
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 267
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 435
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.43
    Marker Score: 985
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.42
    Marker Score: 158
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.37
    Marker Score: 1613
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5610
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 206
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.33
    Marker Score: 779
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.33
    Marker Score: 1021
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.32
    Marker Score: 339
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.31
    Marker Score: 1654
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.29
    Marker Score: 110
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 508
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.28
    Marker Score: 1769
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.22
    Marker Score: 2024
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 255
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.19
    Marker Score: 530
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.19
    Marker Score: 54
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.16
    Marker Score: 153
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 223.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 106
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.14
    Marker Score: 91
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 316
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 207
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1108
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.13
    Marker Score: 1730
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.13
    Marker Score: 948
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 523
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.12
    Marker Score: 46.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.12
    Marker Score: 51.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7524
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 203
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 172
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.11
    Marker Score: 119
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.11
    Marker Score: 80
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.11
    Marker Score: 3966
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 329
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.11
    Marker Score: 117
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.1
    Marker Score: 91
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 172
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.1
    Marker Score: 21.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.1
    Marker Score: 236
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 43

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Other Information

**Key characteristics** - The CYP2C18 gene is located on chromosome 15q21.1. - It is a member of the cytochrome P450 family 2 subfamily C. - The protein is encoded by a single gene. - It is a secreted protein. - It is a homo-tetrameric protein. **Pathways and functions** - The CYP2C18 protein is involved in a variety of metabolic pathways, including the arachidonic acid epoxygenase activity, aromatase activity, biological oxidations, cytochrome p450 - arranged by substrate type, the heme binding, iron ion binding, linoleic acid epoxygenase activity, and retinol metabolic process. **Clinical significance** Mutations in the CYP2C18 gene have been linked to a number of human diseases, including acne, abnormal skin pigmentation, and an increased risk of liver disease.

Genular Protein ID: 289754708

Symbol: CP2CI_HUMAN

Name: Cytochrome P450 2C18

UniProtKB Accession Codes:

P33260 B2R8K2 Q16703 Q16751 Q4VAT5 Q6GRG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 EC 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2009263

Title: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

PubMed ID: 2009263

DOI: 10.1021/bi00227a012

PubMed ID: 8095407

Title:

PubMed ID: 8095407

DOI: 10.1021/bi00056a025

PubMed ID: 8333835

Title: Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18.

PubMed ID: 8333835

DOI: 10.1006/bbrc.1993.1803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 16963442

Title: Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.

PubMed ID: 16963442

DOI: 10.1074/jbc.m606755200

Sequence Information:

  • Length: 490
  • Mass: 55711
  • Checksum: C933CF31F078FD1E
  • Sequence:
    • MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM SKSLTNFSKV 
YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF PVAEKVNKGL GILFSNGKRW 
KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS 
VIFHDRFDYK DQRFLNLMEK FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI 
KSYVLERIKE HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE 
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID 
LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK 
KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP 
PLYQLCFIPV

Genular Protein ID: 1824903753

Symbol: Q7Z348_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z348

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 310
  • Mass: 35558
  • Checksum: C823EFD4AC53C732
  • Sequence:
    • EIRRFCLMTL RNFGMGKRSI EDRVQEEARC LVEELRKTNA SPCDPAFILG CAPCNVICSV 
IFHDRFDYKD QRFLNLMEKF NENLRILSSP WIQEKHNQQS EFTVESLIAT VTDMFGAGTE 
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID 
LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK 
KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP 
PLYQLCFIPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.