Details for: CYP2C18

Gene ID: 1562

Symbol: CYP2C18

Ensembl ID: ENSG00000108242

Description: cytochrome P450 family 2 subfamily C member 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.4929
    Cell Significance Index: 34.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.9467
    Cell Significance Index: 63.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6886
    Cell Significance Index: 77.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1729
    Cell Significance Index: 413.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6266
    Cell Significance Index: 39.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0664
    Cell Significance Index: 16.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0120
    Cell Significance Index: 117.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9743
    Cell Significance Index: 58.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.7416
    Cell Significance Index: 84.6500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.6657
    Cell Significance Index: 4.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4667
    Cell Significance Index: 9.9400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4649
    Cell Significance Index: 4.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4210
    Cell Significance Index: 45.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4122
    Cell Significance Index: 86.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3094
    Cell Significance Index: 21.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.2676
    Cell Significance Index: 150.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2565
    Cell Significance Index: 231.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2336
    Cell Significance Index: 5.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1489
    Cell Significance Index: 2.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1470
    Cell Significance Index: 2.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1422
    Cell Significance Index: 2.4000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1295
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1046
    Cell Significance Index: 17.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0850
    Cell Significance Index: 0.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0677
    Cell Significance Index: 42.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0674
    Cell Significance Index: 3.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0425
    Cell Significance Index: 4.2000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0307
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0254
    Cell Significance Index: 5.0900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0252
    Cell Significance Index: 0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0223
    Cell Significance Index: 6.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0185
    Cell Significance Index: 0.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0117
    Cell Significance Index: 0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0063
    Cell Significance Index: 2.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0018
    Cell Significance Index: 0.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0074
    Cell Significance Index: -1.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0114
    Cell Significance Index: -0.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0153
    Cell Significance Index: -3.0400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0226
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0252
    Cell Significance Index: -3.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0333
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0371
    Cell Significance Index: -4.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0413
    Cell Significance Index: -6.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0447
    Cell Significance Index: -2.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0488
    Cell Significance Index: -2.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0489
    Cell Significance Index: -3.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0508
    Cell Significance Index: -5.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0534
    Cell Significance Index: -0.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0540
    Cell Significance Index: -1.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0543
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0553
    Cell Significance Index: -4.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0555
    Cell Significance Index: -3.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0575
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0580
    Cell Significance Index: -1.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0585
    Cell Significance Index: -1.4600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0588
    Cell Significance Index: -0.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0589
    Cell Significance Index: -1.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0690
    Cell Significance Index: -3.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0728
    Cell Significance Index: -2.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0763
    Cell Significance Index: -1.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0790
    Cell Significance Index: -2.9900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0815
    Cell Significance Index: -0.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0825
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0825
    Cell Significance Index: -2.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0862
    Cell Significance Index: -4.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0869
    Cell Significance Index: -4.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0881
    Cell Significance Index: -2.3600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0940
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0979
    Cell Significance Index: -0.6500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0998
    Cell Significance Index: -0.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1011
    Cell Significance Index: -3.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1040
    Cell Significance Index: -2.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1113
    Cell Significance Index: -2.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1120
    Cell Significance Index: -2.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1122
    Cell Significance Index: -5.8300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1131
    Cell Significance Index: -1.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1134
    Cell Significance Index: -4.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1135
    Cell Significance Index: -3.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1152
    Cell Significance Index: -2.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1178
    Cell Significance Index: -2.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1194
    Cell Significance Index: -5.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1285
    Cell Significance Index: -2.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1320
    Cell Significance Index: -2.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1335
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1338
    Cell Significance Index: -2.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1348
    Cell Significance Index: -1.9300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1364
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CYP2C18 is a membrane-bound enzyme that is primarily expressed in the endoplasmic reticulum of various tissues, including the liver, kidney, and intestine. It belongs to the cytochrome P450 superfamily, which is characterized by the presence of a heme group and a flavin-dependent monooxygenase activity. CYP2C18 is a member of the 2C subfamily, which is known to be involved in the metabolism of a wide range of compounds, including steroids, fatty acids, and xenobiotics. **Pathways and Functions:** CYP2C18 is involved in the metabolism of various compounds through its monooxygenase activity, which involves the incorporation of one atom of oxygen into the substrate. The enzyme is also capable of participating in the epoxygenase pathway, which involves the incorporation of oxygen into arachidonic acid, leading to the formation of epoxyeicosatrienoic acids (EETs). EETs have been shown to have anti-inflammatory and vasodilatory effects. In addition to its metabolic functions, CYP2C18 has been implicated in the regulation of various cellular processes, including cell signaling, apoptosis, and differentiation. The enzyme has also been shown to be involved in the metabolism of retinoic acid, a key regulator of cell growth and differentiation. **Clinical Significance:** CYP2C18 has been implicated in the metabolism of various drugs, including warfarin, which is used to prevent thrombosis. Variations in the CYP2C18 gene have been associated with altered warfarin sensitivity and increased risk of bleeding. Additionally, CYP2C18 has been shown to play a role in the metabolism of other drugs, including certain antidepressants and anti-anxiety medications. Furthermore, CYP2C18 has been implicated in the pathogenesis of various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. The enzyme has been shown to be involved in the metabolism of carcinogens, which can lead to the formation of reactive oxygen species (ROS) and DNA damage, contributing to the development of cancer. In conclusion, CYP2C18 is a key enzyme involved in the metabolism of various endogenous and exogenous compounds. Its involvement in the epoxygenase pathway and its regulation of cellular processes make it an important target for therapeutic intervention. Further research is needed to fully elucidate the clinical significance of CYP2C18 and its role in human disease. **Significantly Expressed Cells:** CYP2C18 is expressed in various tissues, including: * Keratinocyte * Foveolar cell of stomach * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Tuft cell of colon * Absorptive cell * BEST4+ intestinal epithelial cell * Human, intestinal epithelial cell * Intestinal crypt stem cell of colon * Small intestine goblet cell **Proteins:** CYP2C18 is encoded by the CYP2C18 gene, which is located on chromosome 19q13.4. The protein is also known as CP2CI_HUMAN.

Genular Protein ID: 289754708

Symbol: CP2CI_HUMAN

Name: Cytochrome P450 2C18

UniProtKB Accession Codes:

P33260 B2R8K2 Q16703 Q16751 Q4VAT5 Q6GRG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 EC 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2009263

Title: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

PubMed ID: 2009263

DOI: 10.1021/bi00227a012

PubMed ID: 8095407

Title:

PubMed ID: 8095407

DOI: 10.1021/bi00056a025

PubMed ID: 8333835

Title: Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18.

PubMed ID: 8333835

DOI: 10.1006/bbrc.1993.1803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 16963442

Title: Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.

PubMed ID: 16963442

DOI: 10.1074/jbc.m606755200

Sequence Information:

  • Length: 490
  • Mass: 55711
  • Checksum: C933CF31F078FD1E
  • Sequence:
    • MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM SKSLTNFSKV 
YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF PVAEKVNKGL GILFSNGKRW 
KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS 
VIFHDRFDYK DQRFLNLMEK FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI 
KSYVLERIKE HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE 
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID 
LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK 
KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP 
PLYQLCFIPV

Genular Protein ID: 1824903753

Symbol: Q7Z348_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z348

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 310
  • Mass: 35558
  • Checksum: C823EFD4AC53C732
  • Sequence:
    • EIRRFCLMTL RNFGMGKRSI EDRVQEEARC LVEELRKTNA SPCDPAFILG CAPCNVICSV 
IFHDRFDYKD QRFLNLMEKF NENLRILSSP WIQEKHNQQS EFTVESLIAT VTDMFGAGTE 
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID 
LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK 
KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP 
PLYQLCFIPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.