Details for: CYP2D6

Gene ID: 1565

Symbol: CYP2D6

Ensembl ID: ENSG00000100197

Description: cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5644
    Cell Significance Index: 38.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.5634
    Cell Significance Index: 37.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4313
    Cell Significance Index: 272.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6640
    Cell Significance Index: 11.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4654
    Cell Significance Index: 27.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3879
    Cell Significance Index: 350.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3263
    Cell Significance Index: 32.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3163
    Cell Significance Index: 34.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2452
    Cell Significance Index: 1.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2422
    Cell Significance Index: 6.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2184
    Cell Significance Index: 15.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2087
    Cell Significance Index: 4.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1980
    Cell Significance Index: 32.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1935
    Cell Significance Index: 5.5800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1540
    Cell Significance Index: 0.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1440
    Cell Significance Index: 28.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0802
    Cell Significance Index: 0.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0719
    Cell Significance Index: 1.0300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0712
    Cell Significance Index: 0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0672
    Cell Significance Index: 2.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0561
    Cell Significance Index: 11.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0522
    Cell Significance Index: 18.7200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0453
    Cell Significance Index: 0.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0417
    Cell Significance Index: 1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0389
    Cell Significance Index: 1.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0385
    Cell Significance Index: 0.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0382
    Cell Significance Index: 1.4500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0265
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0257
    Cell Significance Index: 2.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0239
    Cell Significance Index: 4.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0228
    Cell Significance Index: 0.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0191
    Cell Significance Index: 13.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0129
    Cell Significance Index: 0.2800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0115
    Cell Significance Index: 0.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0114
    Cell Significance Index: 1.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0113
    Cell Significance Index: 6.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0062
    Cell Significance Index: 2.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0059
    Cell Significance Index: 0.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0028
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0024
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0015
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0019
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0028
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0069
    Cell Significance Index: -0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0073
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0092
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0094
    Cell Significance Index: -1.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0122
    Cell Significance Index: -0.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0124
    Cell Significance Index: -1.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0127
    Cell Significance Index: -0.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0146
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0165
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0166
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0182
    Cell Significance Index: -1.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0183
    Cell Significance Index: -0.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0199
    Cell Significance Index: -0.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0229
    Cell Significance Index: -0.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0229
    Cell Significance Index: -1.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0241
    Cell Significance Index: -0.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0243
    Cell Significance Index: -1.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0256
    Cell Significance Index: -1.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0299
    Cell Significance Index: -1.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0299
    Cell Significance Index: -0.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0312
    Cell Significance Index: -0.5400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0327
    Cell Significance Index: -0.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0334
    Cell Significance Index: -1.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0340
    Cell Significance Index: -1.7700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0344
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0373
    Cell Significance Index: -0.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0385
    Cell Significance Index: -0.3700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0405
    Cell Significance Index: -1.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0410
    Cell Significance Index: -0.5600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0415
    Cell Significance Index: -0.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0417
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genetic Variability:** CYP2D6 is known for its high genetic variability, with multiple alleles and polymorphisms that can affect its expression and activity. This variability is a significant factor in the pharmacokinetics and pharmacodynamics of drugs metabolized by CYP2D6. 2. **Tissue Expression:** CYP2D6 is highly expressed in the liver, colon, and brain, with significant expression in various cell types, including enterocytes, hepatocytes, and GABAergic interneurons. 3. **Metabolic Pathways:** CYP2D6 is involved in the metabolism of a wide range of substances, including drugs, hormones, neurotransmitters, and xenobiotics. Its metabolic pathways include the oxidation of lipophilic compounds, the epoxidation of anandamide, and the demethylation of retinol. **Pathways and Functions:** 1. **Xenobiotic Metabolism:** CYP2D6 plays a crucial role in the phase I metabolism of xenobiotics, which involves the oxidation of lipophilic compounds to more water-soluble products. This process is essential for the activation and inactivation of drugs, hormones, and other foreign substances. 2. **Anandamide Metabolism:** CYP2D6 is involved in the epoxidation of anandamide, a neurotransmitter involved in pain modulation and inflammation. 3. **Hormone Metabolism:** CYP2D6 is involved in the metabolism of various hormones, including estrogen and cholesterol. 4. **Neurotransmitter Metabolism:** CYP2D6 is involved in the metabolism of various neurotransmitters, including dopamine and serotonin. 5. **Phase I Functionalization:** CYP2D6 is involved in the phase I functionalization of compounds, which involves the oxidation of lipophilic compounds to more water-soluble products. **Clinical Significance:** 1. **Pharmacokinetics and Pharmacodynamics:** CYP2D6 is a critical enzyme in the metabolism of many drugs, including antidepressants, antipsychotics, and anti-inflammatory agents. Genetic variability in CYP2D6 can affect the pharmacokinetics and pharmacodynamics of these drugs, leading to significant clinical consequences. 2. **Cancer Treatment:** CYP2D6 is involved in the metabolism of various anticancer agents, including tamoxifen and irinotecan. Genetic variability in CYP2D6 can affect the efficacy and toxicity of these drugs. 3. **Neurological Disorders:** CYP2D6 is involved in the metabolism of various neurotransmitters, including dopamine and serotonin, which are implicated in various neurological disorders, including Parkinson's disease and depression. 4. **Xenobiotic Toxicity:** CYP2D6 is involved in the metabolism of various xenobiotics, including pesticides and heavy metals, which can have significant clinical consequences. In conclusion, CYP2D6 is a complex and multifunctional enzyme that plays a critical role in the metabolism of a wide range of substances. Its genetic variability and tissue expression patterns make it a significant factor in both normal physiology and disease states. Further research is needed to fully understand the mechanisms of CYP2D6 and its role in human health and disease.

Genular Protein ID: 1936228722

Symbol: CP2D6_HUMAN

Name: CYPIID6

UniProtKB Accession Codes:

P10635 Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 87 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 Rhea 48 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3410476

Title: Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

PubMed ID: 3410476

DOI: 10.1016/0888-7543(88)90100-0

PubMed ID: 3123997

Title: Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

PubMed ID: 3123997

DOI: 10.1038/331442a0

PubMed ID: 2574001

Title: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

PubMed ID: 2574001

PubMed ID: 15768052

Title: Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

PubMed ID: 15768052

DOI: 10.1038/sj.tpj.6500305

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 18698000

Title: The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

PubMed ID: 18698000

DOI: 10.1124/jpet.108.141796

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21289075

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

PubMed ID: 21289075

DOI: 10.1124/dmd.110.036707

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16352597

Title: Crystal structure of human cytochrome P450 2D6.

PubMed ID: 16352597

DOI: 10.1074/jbc.m511232200

PubMed ID: 1844820

Title: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.

PubMed ID: 1844820

DOI: 10.1097/00008571-199110000-00005

PubMed ID: 8287064

Title: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

PubMed ID: 8287064

DOI: 10.1097/00008571-199310000-00005

PubMed ID: 7845481

Title: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine.

PubMed ID: 7845481

DOI: 10.1007/bf00178963

PubMed ID: 7868129

Title: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution.

PubMed ID: 7868129

DOI: 10.1007/bf00225204

PubMed ID: 8971426

Title: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.

PubMed ID: 8971426

DOI: 10.1046/j.1365-2125.1996.00489.x

PubMed ID: 8655150

Title: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine.

PubMed ID: 8655150

DOI: 10.1007/bf02281880

PubMed ID: 9241659

Title: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

PubMed ID: 9241659

DOI: 10.1097/00008571-199706000-00004

PubMed ID: 10064570

Title: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese.

PubMed ID: 10064570

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 25469868

Title: In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.

PubMed ID: 25469868

DOI: 10.1111/bcpt.12363

Sequence Information:

  • Length: 497
  • Mass: 55769
  • Checksum: 542B1D505DF3CDAC
  • Sequence:
    • MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 
HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 
FAFLVSPSPY ELCAVPR

Genular Protein ID: 240017946

Symbol: Q5Y7H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7H2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 2 SAM 2

Citations:

PubMed ID: 15051713

Title: A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

PubMed ID: 15051713

DOI: 10.1074/jbc.M402337200

Sequence Information:

  • Length: 142
  • Mass: 15186
  • Checksum: 755EB2341C0C7A6E
  • Sequence:
    • QLRRRFGDVF SLQLAWTPVV VAQWAGGRAR GAGDPRRGHR RPPACAHHPD PGFRAAFPRT 
PLSPQRSLGQ SREQRDRLPH LRAPLRVRRP SLPQAAGPSS GGTEGGVGLS ARGAECCPRP 
PAYPSAGWQG PTLPKGFPDP AG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.