Details for: CYP2D6

Gene ID: 1565

Symbol: CYP2D6

Ensembl ID: ENSG00000100197

Description: cytochrome P450 family 2 subfamily D member 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.83
    Marker Score: 2817
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.49
    Marker Score: 8017
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.36
    Marker Score: 5866
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.29
    Marker Score: 8264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.87
    Marker Score: 1799.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 396.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3008.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.66
    Marker Score: 705.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.62
    Marker Score: 890
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.57
    Marker Score: 2720
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.45
    Marker Score: 138.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.44
    Marker Score: 1229
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2412
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.35
    Marker Score: 239
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.32
    Marker Score: 92
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 510
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1137
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.13
    Marker Score: 83.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.13
    Marker Score: 506
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.13
    Marker Score: 1222
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.12
    Marker Score: 122
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 7003
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.11
    Marker Score: 525
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.1
    Marker Score: 1560
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 73
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 151
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.09
    Marker Score: 468
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.09
    Marker Score: 1723
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.09
    Marker Score: 213
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.08
    Marker Score: 392
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.08
    Marker Score: 637
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.08
    Marker Score: 3012
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.08
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.08
    Marker Score: 238
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.07
    Marker Score: 126
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 649
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.07
    Marker Score: 919
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 123
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.07
    Marker Score: 2488

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Other Information

**Key characteristics:** - The CYP2D6 gene is located on chromosome 15q21.1. - It is a large gene, encoding for a protein of 1,189 amino acids. - The protein is expressed in high levels in the liver and other tissues with high metabolic activity. **Pathways and functions:** - CYP2D6 enzymes catalyze a variety of chemical reactions, including the metabolism of drugs, fatty acids, and other molecules. - These reactions can be divided into two main categories: oxidative phosphorylation and non-oxidative metabolism. - In oxidative phosphorylation, CYP2D6 enzymes transfer electrons to oxygen, which is reduced to water. - In non-oxidative metabolism, CYP2D6 enzymes reduce other molecules, such as drugs and fatty acids, to their corresponding alcohols or alkanes. **Clinical significance:** - CYP2D6 enzymes are involved in a variety of human diseases, including liver disease, cancer, and inflammation. - CYP2D6 inhibitors are being investigated as potential treatments for these diseases. - Inhibition of CYP2D6 enzymes can lead to the accumulation of toxic metabolites, which can damage cells and tissues. **Conclusion:** The CYP2D6 gene is an important regulator of metabolism. Its expression and activity are regulated by a variety of factors, including hormones, nutrients, and environmental toxins. Dysregulation of CYP2D6 enzymes has been linked to a number of human diseases, highlighting the importance of this gene in maintaining human health.

Genular Protein ID: 1936228722

Symbol: CP2D6_HUMAN

Name: CYPIID6

UniProtKB Accession Codes:

P10635 Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 87 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 Rhea 48 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3410476

Title: Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

PubMed ID: 3410476

DOI: 10.1016/0888-7543(88)90100-0

PubMed ID: 3123997

Title: Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

PubMed ID: 3123997

DOI: 10.1038/331442a0

PubMed ID: 2574001

Title: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

PubMed ID: 2574001

PubMed ID: 15768052

Title: Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

PubMed ID: 15768052

DOI: 10.1038/sj.tpj.6500305

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 18698000

Title: The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

PubMed ID: 18698000

DOI: 10.1124/jpet.108.141796

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21289075

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

PubMed ID: 21289075

DOI: 10.1124/dmd.110.036707

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16352597

Title: Crystal structure of human cytochrome P450 2D6.

PubMed ID: 16352597

DOI: 10.1074/jbc.m511232200

PubMed ID: 1844820

Title: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.

PubMed ID: 1844820

DOI: 10.1097/00008571-199110000-00005

PubMed ID: 8287064

Title: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

PubMed ID: 8287064

DOI: 10.1097/00008571-199310000-00005

PubMed ID: 7845481

Title: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine.

PubMed ID: 7845481

DOI: 10.1007/bf00178963

PubMed ID: 7868129

Title: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution.

PubMed ID: 7868129

DOI: 10.1007/bf00225204

PubMed ID: 8971426

Title: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.

PubMed ID: 8971426

DOI: 10.1046/j.1365-2125.1996.00489.x

PubMed ID: 8655150

Title: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine.

PubMed ID: 8655150

DOI: 10.1007/bf02281880

PubMed ID: 9241659

Title: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

PubMed ID: 9241659

DOI: 10.1097/00008571-199706000-00004

PubMed ID: 10064570

Title: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese.

PubMed ID: 10064570

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 25469868

Title: In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.

PubMed ID: 25469868

DOI: 10.1111/bcpt.12363

Sequence Information:

  • Length: 497
  • Mass: 55769
  • Checksum: 542B1D505DF3CDAC
  • Sequence:
    • MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 
HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 
FAFLVSPSPY ELCAVPR

Genular Protein ID: 240017946

Symbol: Q5Y7H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7H2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 2 SAM 2

Citations:

PubMed ID: 15051713

Title: A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

PubMed ID: 15051713

DOI: 10.1074/jbc.M402337200

Sequence Information:

  • Length: 142
  • Mass: 15186
  • Checksum: 755EB2341C0C7A6E
  • Sequence:
    • QLRRRFGDVF SLQLAWTPVV VAQWAGGRAR GAGDPRRGHR RPPACAHHPD PGFRAAFPRT 
PLSPQRSLGQ SREQRDRLPH LRAPLRVRRP SLPQAAGPSS GGTEGGVGLS ARGAECCPRP 
PAYPSAGWQG PTLPKGFPDP AG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.