CYP2D6 | ENSG00000100197 | NCBI 1565

Details for: CYP2D6

Gene ID: 1565

Symbol: CYP2D6

Ensembl ID: ENSG00000100197

Description: cytochrome P450 family 2 subfamily D member 6

Associated with

Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Miscellaneous substrates
(R-HSA-211958)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Alkaloid catabolic process
(GO:0009822)
Alkaloid metabolic process
(GO:0009820)
Anandamide 8,9 epoxidase activity
(GO:0062187)
Anandamide 11,12 epoxidase activity
(GO:0062188)
Anandamide 14,15 epoxidase activity
(GO:0062189)
Arachidonic acid metabolic process
(GO:0019369)
Cholesterol metabolic process
(GO:0008203)
Coumarin metabolic process
(GO:0009804)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Isoquinoline alkaloid metabolic process
(GO:0033076)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Negative regulation of binding
(GO:0051100)
Negative regulation of cellular organofluorine metabolic process
(GO:0090350)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Retinol metabolic process
(GO:0042572)
Steroid metabolic process
(GO:0008202)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

CYPIID6
Q5Y7H2_HUMAN

Genular Protein ID: 1936228722

Symbol: CP2D6_HUMAN

Name: CYPIID6

UniProtKB Accession Codes:

P10635 Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8

Database IDs:

Citations:

PubMed ID: 3410476

Title: Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

PubMed ID: 3410476

DOI: 10.1016/0888-7543(88)90100-0

PubMed ID: 3123997

Title: Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

PubMed ID: 3123997

DOI: 10.1038/331442a0

PubMed ID: 2574001

Title: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

PubMed ID: 2574001

PubMed ID: 15768052

Title: Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

PubMed ID: 15768052

DOI: 10.1038/sj.tpj.6500305

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 18698000

Title: The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

PubMed ID: 18698000

DOI: 10.1124/jpet.108.141796

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21289075

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

PubMed ID: 21289075

DOI: 10.1124/dmd.110.036707

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16352597

Title: Crystal structure of human cytochrome P450 2D6.

PubMed ID: 16352597

DOI: 10.1074/jbc.m511232200

PubMed ID: 1844820

Title: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.

PubMed ID: 1844820

DOI: 10.1097/00008571-199110000-00005

PubMed ID: 8287064

Title: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

PubMed ID: 8287064

DOI: 10.1097/00008571-199310000-00005

PubMed ID: 7845481

Title: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine.

PubMed ID: 7845481

DOI: 10.1007/bf00178963

PubMed ID: 7868129

Title: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution.

PubMed ID: 7868129

DOI: 10.1007/bf00225204

PubMed ID: 8971426

Title: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.

PubMed ID: 8971426

DOI: 10.1046/j.1365-2125.1996.00489.x

PubMed ID: 8655150

Title: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine.

PubMed ID: 8655150

DOI: 10.1007/bf02281880

PubMed ID: 9241659

Title: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

PubMed ID: 9241659

DOI: 10.1097/00008571-199706000-00004

PubMed ID: 10064570

Title: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese.

PubMed ID: 10064570

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 25469868

Title: In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.

PubMed ID: 25469868

DOI: 10.1111/bcpt.12363

Sequence Information:

Length: 497
Mass: 55769
Checksum: 542B1D505DF3CDAC
Sequence:

MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 
HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 
LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 
FAFLVSPSPY ELCAVPR

Genular Protein ID: 240017946

Symbol: Q5Y7H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7H2

Database IDs:

Citations:

PubMed ID: 15051713

Title: A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

PubMed ID: 15051713

DOI: 10.1074/jbc.M402337200

Sequence Information:

Length: 142
Mass: 15186
Checksum: 755EB2341C0C7A6E
Sequence:

QLRRRFGDVF SLQLAWTPVV VAQWAGGRAR GAGDPRRGHR RPPACAHHPD PGFRAAFPRT 
PLSPQRSLGQ SREQRDRLPH LRAPLRVRRP SLPQAAGPSS GGTEGGVGLS ARGAECCPRP 
PAYPSAGWQG PTLPKGFPDP AG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2D6

Associated with

Other Information

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. PubMed ID: 3410476

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. PubMed ID: 3123997

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. PubMed ID: 2574001

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. PubMed ID: 15768052

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. PubMed ID: 10681376

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. PubMed ID: 18698000

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. PubMed ID: 20972997

Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. PubMed ID: 21289075

Cholesterol 25-hydroxylation activity of CYP3A. PubMed ID: 21576599

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of human cytochrome P450 2D6. PubMed ID: 16352597

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. PubMed ID: 1844820

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. PubMed ID: 8287064

A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. PubMed ID: 7845481

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution. PubMed ID: 7868129

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. PubMed ID: 8971426

An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. PubMed ID: 8655150

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. PubMed ID: 9241659

G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. PubMed ID: 10064570

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population. PubMed ID: 25469868

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. PubMed ID: 15051713