Details for: CYP2D8P

Gene ID: 1568

Symbol: CYP2D8P

Ensembl ID: ENSG00000226450

Description: ccytochrome P450 family 2 subfamily D member 8, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1194
    Cell Significance Index: 23.9500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1031
    Cell Significance Index: 1.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0208
    Cell Significance Index: 0.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0050
    Cell Significance Index: 0.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0040
    Cell Significance Index: -0.0900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0041
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0137
    Cell Significance Index: -0.6400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0137
    Cell Significance Index: -0.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0148
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0148
    Cell Significance Index: -0.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0187
    Cell Significance Index: -0.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0193
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0297
    Cell Significance Index: -0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0372
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0383
    Cell Significance Index: -1.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0396
    Cell Significance Index: -0.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0413
    Cell Significance Index: -0.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0414
    Cell Significance Index: -1.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0434
    Cell Significance Index: -0.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0442
    Cell Significance Index: -1.5500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0461
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0461
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0499
    Cell Significance Index: -1.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0619
    Cell Significance Index: -1.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0632
    Cell Significance Index: -1.6100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0632
    Cell Significance Index: -1.0800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0637
    Cell Significance Index: -0.6600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0685
    Cell Significance Index: -0.8200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0725
    Cell Significance Index: -0.6000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0742
    Cell Significance Index: -0.9700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0790
    Cell Significance Index: -0.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0790
    Cell Significance Index: -1.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0795
    Cell Significance Index: -1.5700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0880
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0882
    Cell Significance Index: -1.5200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0895
    Cell Significance Index: -1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0906
    Cell Significance Index: -1.8900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0913
    Cell Significance Index: -0.8500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0942
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0975
    Cell Significance Index: -1.4400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0979
    Cell Significance Index: -1.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0985
    Cell Significance Index: -2.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0987
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1003
    Cell Significance Index: -1.4400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1024
    Cell Significance Index: -1.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1057
    Cell Significance Index: -1.3200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1059
    Cell Significance Index: -1.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1073
    Cell Significance Index: -1.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1143
    Cell Significance Index: -1.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1147
    Cell Significance Index: -1.9500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1156
    Cell Significance Index: -1.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1164
    Cell Significance Index: -1.3800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1174
    Cell Significance Index: -1.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1174
    Cell Significance Index: -1.5600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1190
    Cell Significance Index: -1.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1190
    Cell Significance Index: -1.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1195
    Cell Significance Index: -1.5600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1196
    Cell Significance Index: -1.2400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1207
    Cell Significance Index: -1.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1218
    Cell Significance Index: -1.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1228
    Cell Significance Index: -1.4500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1229
    Cell Significance Index: -1.3900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1232
    Cell Significance Index: -1.3300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1238
    Cell Significance Index: -1.4900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1250
    Cell Significance Index: -1.4200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1254
    Cell Significance Index: -1.5300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1261
    Cell Significance Index: -1.5500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1265
    Cell Significance Index: -1.4700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1266
    Cell Significance Index: -1.5800
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.1282
    Cell Significance Index: -1.5500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1282
    Cell Significance Index: -1.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1286
    Cell Significance Index: -3.3000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1299
    Cell Significance Index: -1.5600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1302
    Cell Significance Index: -1.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1323
    Cell Significance Index: -1.6700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1330
    Cell Significance Index: -1.5400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1341
    Cell Significance Index: -1.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1350
    Cell Significance Index: -1.2800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1352
    Cell Significance Index: -1.5500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1361
    Cell Significance Index: -1.3900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1364
    Cell Significance Index: -1.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CYP2D8P gene is a member of the cytochrome P450 family, which plays a crucial role in the metabolism of various endogenous and exogenous compounds. However, unlike its functional counterparts, CYP2D8P is a pseudogene, devoid of a coding sequence. Despite this, its expression has been detected in a range of cell types, including retinal rod cells, pigmented ciliary epithelial cells, neurons, and others. This suggests that CYP2D8P may be involved in regulating cellular processes, such as cell differentiation, proliferation, or survival, albeit in a non-coding capacity. **Pathways and Functions:** The precise mechanisms underlying CYP2D8P's functions remain unclear. However, research has implicated this pseudogene in various signaling pathways, including those involved in cell growth, differentiation, and apoptosis. For instance, studies have shown that CYP2D8P is co-expressed with genes involved in the Wnt/β-catenin pathway, a critical regulator of cell proliferation and differentiation. Additionally, CYP2D8P has been linked to the regulation of autophagy, a process essential for maintaining cellular homeostasis. Furthermore, CYP2D8P has been shown to interact with other genes involved in the immune response, suggesting a potential role in modulating immune cell function. Its expression in neurons and other cells has also raised questions about its involvement in neurodevelopmental processes and neurological disorders. **Clinical Significance:** While the functional significance of CYP2D8P remains uncertain, its expression in various tissues and cell types has sparked interest in its potential applications in clinical settings. For example, CYP2D8P's presence in retinal cells has led researchers to explore its role in eye diseases, such as retinitis pigmentosa. Additionally, its expression in neurons has raised questions about its involvement in neurological disorders, such as Alzheimer's disease or Parkinson's disease. Furthermore, CYP2D8P's interactions with immune-related genes have led researchers to investigate its potential as a biomarker for immune-mediated diseases, such as multiple sclerosis or rheumatoid arthritis. While further research is needed to fully elucidate CYP2D8P's clinical significance, its unique expression profile and potential implications in various cellular processes make it an intriguing area of investigation. In conclusion, the CYP2D8P gene, despite being a pseudogene, holds significant promise for our understanding of cellular processes and its potential applications in clinical settings. Further research is needed to fully elucidate its functions and implications, but its unique expression profile and interactions with other genes make it an exciting area of investigation in the field of immunology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.