Details for: GRK3

Gene ID: 157

Symbol: GRK3

Ensembl ID: ENSG00000100077

Description: G protein-coupled receptor kinase 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 5.19
    Marker Score: 2,518
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.97
    Marker Score: 4,955
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.58
    Marker Score: 1,309
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.06
    Marker Score: 14,162
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.79
    Marker Score: 41,760
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.54
    Marker Score: 33,806
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.54
    Marker Score: 10,534
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.49
    Marker Score: 49,441
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.41
    Marker Score: 91,548
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.36
    Marker Score: 87,208
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8,821
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17,055
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.12
    Marker Score: 3,568
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.07
    Marker Score: 5,911
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.03
    Marker Score: 43,395
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.9
    Marker Score: 945
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17,800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.87
    Marker Score: 17,581
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.86
    Marker Score: 1,662
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.85
    Marker Score: 113,780
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,767
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.74
    Marker Score: 971
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.67
    Marker Score: 860
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 17,051
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.61
    Marker Score: 6,694
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.56
    Marker Score: 3,173
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,383
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.53
    Marker Score: 1,528
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1,739
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.43
    Marker Score: 2,749
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.39
    Marker Score: 1,560
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.37
    Marker Score: 495
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.32
    Marker Score: 5,513
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.25
    Marker Score: 523
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.25
    Marker Score: 1,294
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.24
    Marker Score: 338
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2
    Marker Score: 7,231
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,636
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.17
    Marker Score: 392
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.15
    Marker Score: 4,104
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4,634
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 657
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1
    Marker Score: 773
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.08
    Marker Score: 1,175
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 392
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.05
    Marker Score: 730
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.05
    Marker Score: 582
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1,893
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.03
    Marker Score: 57,692
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 323
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,992
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1
    Marker Score: 1,206
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 834
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.96
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 250
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.95
    Marker Score: 381
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.94
    Marker Score: 1,832
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.94
    Marker Score: 23,961
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.93
    Marker Score: 609
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.92
    Marker Score: 326
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,081
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.89
    Marker Score: 280
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.88
    Marker Score: 867
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.84
    Marker Score: 2,020
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.83
    Marker Score: 1,111
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 736
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8
    Marker Score: 481
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,316
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.79
    Marker Score: 699
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.78
    Marker Score: 464
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.77
    Marker Score: 439
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 422
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.76
    Marker Score: 948
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.76
    Marker Score: 261
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.74
    Marker Score: 842
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1,123
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.69
    Marker Score: 262
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.69
    Marker Score: 1,197
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.67
    Marker Score: 317
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 320
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.67
    Marker Score: 405
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.66
    Marker Score: 1,654

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphorylation Activity:** GRK3 possesses a high degree of specificity for phosphorylating GPCRs, particularly those belonging to the beta-adrenergic receptor family. This phosphorylation event triggers a cascade of downstream signaling events, leading to the desensitization of GPCR signaling. 2. **Desensitization of GPCR Signaling:** GRK3's primary function is to regulate the desensitization of GPCR signaling, which involves the phosphorylation and internalization of GPCRs. This process prevents the continuous activation of GPCRs, thereby preventing an overactive signaling response. 3. **Regulation of Membrane Trafficking:** GRK3 has been implicated in regulating membrane trafficking, including clathrin-mediated endocytosis and vesicle-mediated transport. This suggests that GRK3 plays a role in modulating the internalization and recycling of GPCRs. 4. **Expression in Specific Cell Types:** GRK3 is expressed in a wide range of cell types, including epicardial adipocytes, retinal ganglion cells, and cardiac muscle cells. This suggests that GRK3 may play a role in various physiological and pathological processes, including cardiovascular disease and neurodegenerative disorders. **Pathways and Functions:** 1. **GPCR Signaling Pathway:** GRK3 regulates the desensitization of GPCR signaling, which involves the phosphorylation and internalization of GPCRs. This process prevents the continuous activation of GPCRs, thereby preventing an overactive signaling response. 2. **Membrane Trafficking:** GRK3 has been implicated in regulating membrane trafficking, including clathrin-mediated endocytosis and vesicle-mediated transport. This suggests that GRK3 plays a role in modulating the internalization and recycling of GPCRs. 3. **Signal Transduction:** GRK3's phosphorylation activity triggers a cascade of downstream signaling events, leading to the regulation of various cellular processes, including gene expression, cell proliferation, and differentiation. 4. **Regulation of Cell Projection:** GRK3 has been implicated in regulating cell projection, including the formation and maintenance of dendritic spines in neurons. **Clinical Significance:** 1. **Cardiovascular Disease:** GRK3 has been implicated in the regulation of cardiac function and the development of cardiovascular disease. Alterations in GRK3 expression and function may contribute to the pathogenesis of cardiovascular disease. 2. **Neurodegenerative Disorders:** GRK3 has been implicated in the regulation of neuronal signaling and the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** GRK3 has been implicated in the regulation of cell growth and differentiation, and alterations in GRK3 expression and function may contribute to the development of cancer. 4. **Neurodevelopmental Disorders:** GRK3 has been implicated in the regulation of neuronal development and the development of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, GRK3 is a critical regulator of GPCR signaling and cellular processes, and alterations in its expression and function may contribute to various physiological and pathological processes, including cardiovascular disease, neurodegenerative disorders, cancer, and neurodevelopmental disorders. Further research is needed to fully elucidate the mechanisms by which GRK3 regulates GPCR signaling and cellular processes, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 39246729

Symbol: ARBK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35626 Q9UGW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8427589

Title: Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2.

PubMed ID: 8427589

DOI: 10.1006/bbrc.1993.1072

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 688
  • Mass: 79710
  • Checksum: 50844236A01C1423
  • Sequence:
    • MADLEAVLAD VSYLMAMEKS KATPAARASK RIVLPEPSIR SVMQKYLAER NEITFDKIFN 
QKIGFLLFKD FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC 
SHPFSKQAVE HVQSHLSKKQ VTSTLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV 
ELNIHLTMNE FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDLH YHLSQHGVFS EKEMRFYATE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH ARISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGTAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VELPDTFSPE 
LKSLLEGLLQ RDVSKRLGCH GGGSQEVKEH SFFKGVDWQH VYLQKYPPPL IPPRGEVNAA 
DAFDIGSFDE EDTKGIKLLD CDQELYKNFP LVISERWQQE VTETVYEAVN ADTDKIEARK 
RAKNKQLGHE EDYALGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQNL 
LTMEQILSVE ETQIKDKKCI LFRIKGGKQF VLQCESDPEF VQWKKELNET FKEAQRLLRR 
APKFLNKPRS GTVELPKPSL CHRNSNGL

Genular Protein ID: 784184776

Symbol: Q8N433_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N433

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 7 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 RuleBase 2 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 387
  • Mass: 44607
  • Checksum: BB025E2FF2DDFFCC
  • Sequence:
    • MADLEAVLAD VSYLMAMEKS KATPAARASK RIVLPEPSIR SVMQKYLAER NEITFDKIFN 
QKIGFLLFKD FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC 
SHPFSKQAVE HVQSHLSKKQ VTSTLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV 
ELNIHLTMNE FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDLH YHLSQHGVFS EKEMRFYATE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH ARISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGTAYDS SADWFSLGCM LFKLLRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.