Details for: GRK3

Gene ID: 157

Symbol: GRK3

Ensembl ID: ENSG00000100077

Description: G protein-coupled receptor kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 5.19
    Marker Score: 2518
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.97
    Marker Score: 4955
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.58
    Marker Score: 1309
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.06
    Marker Score: 14162
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.79
    Marker Score: 41760
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.54
    Marker Score: 33806
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.54
    Marker Score: 10533.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.49
    Marker Score: 49441
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.41
    Marker Score: 91547.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.36
    Marker Score: 87208
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8821
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17055
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.12
    Marker Score: 3568
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.07
    Marker Score: 5911
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.03
    Marker Score: 43395
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.9
    Marker Score: 945
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.87
    Marker Score: 17581
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.86
    Marker Score: 1661.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.85
    Marker Score: 113780
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15767
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.74
    Marker Score: 971
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.67
    Marker Score: 859.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 17051
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.61
    Marker Score: 6694
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.56
    Marker Score: 3173
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2383
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.53
    Marker Score: 1528
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1739
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.43
    Marker Score: 2749
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.39
    Marker Score: 1560
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.37
    Marker Score: 494.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.32
    Marker Score: 5513
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.25
    Marker Score: 523
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.25
    Marker Score: 1294
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.24
    Marker Score: 338
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2
    Marker Score: 7230.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18636
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.17
    Marker Score: 392
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.15
    Marker Score: 4104
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4634
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 657
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1
    Marker Score: 773
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.08
    Marker Score: 1174.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 392
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.05
    Marker Score: 730
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.05
    Marker Score: 582
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1892.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.03
    Marker Score: 57692
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 323
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71767.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47992
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1
    Marker Score: 1206
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 834
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.96
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 250
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.95
    Marker Score: 381
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.94
    Marker Score: 1832
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.94
    Marker Score: 23961
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.93
    Marker Score: 609
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.92
    Marker Score: 326
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5081
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.89
    Marker Score: 280
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.88
    Marker Score: 867
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.84
    Marker Score: 2020
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.83
    Marker Score: 1111
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 736
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8
    Marker Score: 481
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3316
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.79
    Marker Score: 699
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.78
    Marker Score: 463.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.77
    Marker Score: 439
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 422
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.76
    Marker Score: 948
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.76
    Marker Score: 261
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.74
    Marker Score: 842
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1123
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.69
    Marker Score: 262
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.69
    Marker Score: 1196.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.67
    Marker Score: 317
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 320
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.67
    Marker Score: 405
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.66
    Marker Score: 1654

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Other Information

**Key characteristics:** * GRK3 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the G protein-coupled receptor kinase family, which are a large superfamily of cell surface receptors that are activated by the binding of G proteins. * GRK3 is a non-tyrosine kinase, meaning that it does not require the phosphorylation of a tyrosine residue for its activation. * It is a ubiquitination-dependent kinase, meaning that its activity is regulated by the proteolytic degradation of its cytoplasmic domain. **Pathways and functions:** * GRK3 is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. * In endothelial cells, GRK3 is essential for the internalization of LDL particles, which is important for the development of atherosclerosis. * In smooth muscle cells, GRK3 is involved in the regulation of muscle tone and contraction. * In immune cells, GRK3 is a key regulator of immune responses, and its activity is critical for the activation of immune cells. **Clinical significance:** * Mutations in GRK3 have been linked to a number of human diseases, including atherosclerosis, cancer, and immune disorders. * In atherosclerosis, GRK3 mutations can lead to the internalization of LDL particles and the development of plaque buildup in blood vessels, which can eventually lead to heart disease. * In cancer, GRK3 mutations can promote tumor growth and metastasis. * In immune disorders, GRK3 mutations can lead to the activation of immune cells, which can contribute to the development of autoimmune diseases. **Additional notes:** * GRK3 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein, and there are a number of drugs that target GRK3.

Genular Protein ID: 39246729

Symbol: ARBK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35626 Q9UGW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8427589

Title: Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2.

PubMed ID: 8427589

DOI: 10.1006/bbrc.1993.1072

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 688
  • Mass: 79710
  • Checksum: 50844236A01C1423
  • Sequence:
    • MADLEAVLAD VSYLMAMEKS KATPAARASK RIVLPEPSIR SVMQKYLAER NEITFDKIFN 
QKIGFLLFKD FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC 
SHPFSKQAVE HVQSHLSKKQ VTSTLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV 
ELNIHLTMNE FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDLH YHLSQHGVFS EKEMRFYATE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH ARISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGTAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VELPDTFSPE 
LKSLLEGLLQ RDVSKRLGCH GGGSQEVKEH SFFKGVDWQH VYLQKYPPPL IPPRGEVNAA 
DAFDIGSFDE EDTKGIKLLD CDQELYKNFP LVISERWQQE VTETVYEAVN ADTDKIEARK 
RAKNKQLGHE EDYALGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQNL 
LTMEQILSVE ETQIKDKKCI LFRIKGGKQF VLQCESDPEF VQWKKELNET FKEAQRLLRR 
APKFLNKPRS GTVELPKPSL CHRNSNGL

Genular Protein ID: 784184776

Symbol: Q8N433_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N433

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 7 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 RuleBase 2 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 387
  • Mass: 44607
  • Checksum: BB025E2FF2DDFFCC
  • Sequence:
    • MADLEAVLAD VSYLMAMEKS KATPAARASK RIVLPEPSIR SVMQKYLAER NEITFDKIFN 
QKIGFLLFKD FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC 
SHPFSKQAVE HVQSHLSKKQ VTSTLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV 
ELNIHLTMNE FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDLH YHLSQHGVFS EKEMRFYATE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH ARISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGTAYDS SADWFSLGCM LFKLLRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.