CYP2E1 | ENSG00000130649 | NCBI 1571

Details for: CYP2E1

Gene ID: 1571

Symbol: CYP2E1

Ensembl ID: ENSG00000130649

Description: cytochrome P450 family 2 subfamily E member 1

Associated with

Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Paracetamol adme
(R-HSA-9753281)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
4-nitrophenol 2-monooxygenase activity
(GO:0018601)
4-nitrophenol metabolic process
(GO:0018960)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Benzene metabolic process
(GO:0018910)
Carbon tetrachloride metabolic process
(GO:0018885)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Halogenated hydrocarbon metabolic process
(GO:0042197)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Mitochondrial inner membrane
(GO:0005743)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
(GO:0016709)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Oxygen binding
(GO:0019825)
Response to bacterium
(GO:0009617)
Steroid metabolic process
(GO:0008202)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

4-nitrophenol 2-hydroxylase

Genular Protein ID: 50090631

Symbol: CP2E1_HUMAN

Name: 4-nitrophenol 2-hydroxylase

UniProtKB Accession Codes:

P05181 Q5VZD5 Q6NWT9 Q9UK47

Database IDs:

Citations:

PubMed ID: 3782137

Title: Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PubMed ID: 3782137

DOI: 10.1016/s0021-9258(18)66620-7

PubMed ID: 3233219

Title: Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.

PubMed ID: 3233219

DOI: 10.1021/bi00425a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3675576

Title: Purification and characterization of human liver cytochrome P-450-ALC.

PubMed ID: 3675576

DOI: 10.1016/0006-291x(87)91100-4

PubMed ID: 2587619

Title: Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation.

PubMed ID: 2587619

DOI: 10.1159/000138590

PubMed ID: 8031147

Title: Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

PubMed ID: 8031147

DOI: 10.1006/abbi.1994.1280

PubMed ID: 9348445

Title: Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

PubMed ID: 9348445

DOI: 10.1021/tx970048z

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18818195

Title: Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

PubMed ID: 18818195

DOI: 10.1074/jbc.m805999200

PubMed ID: 9058590

Title: Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

PubMed ID: 9058590

PubMed ID: 9918138

Title: Detection and characterization of novel polymorphisms in the CYP2E1 gene.

PubMed ID: 9918138

DOI: 10.1097/00008571-199812000-00011

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

Length: 493
Mass: 56849
Checksum: ED0399E32A005644
Sequence:

MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL 
AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP 
TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI 
ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA 
EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF 
ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK 
FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC 
IPPRYKLCVI PRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2E1

Associated with

Other Information

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. PubMed ID: 3782137

Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. PubMed ID: 3233219

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of human liver cytochrome P-450-ALC. PubMed ID: 3675576

Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation. PubMed ID: 2587619

Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. PubMed ID: 8031147

Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1. PubMed ID: 9348445

Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. PubMed ID: 10553002

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. PubMed ID: 18577768

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. PubMed ID: 18818195

Genetic polymorphism of human CYP2E1: characterization of two variant alleles. PubMed ID: 9058590

Detection and characterization of novel polymorphisms in the CYP2E1 gene. PubMed ID: 9918138

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410