Details for: CYP2E1

Gene ID: 1571

Symbol: CYP2E1

Ensembl ID: ENSG00000130649

Description: cytochrome P450 family 2 subfamily E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.6874
    Cell Significance Index: -3.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.5336
    Cell Significance Index: -3.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.8952
    Cell Significance Index: -4.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.1870
    Cell Significance Index: 70.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.1712
    Cell Significance Index: -3.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.8259
    Cell Significance Index: 26.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7593
    Cell Significance Index: 349.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1296
    Cell Significance Index: 36.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0777
    Cell Significance Index: 48.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9910
    Cell Significance Index: 21.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7928
    Cell Significance Index: 150.8800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.6937
    Cell Significance Index: 5.3300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6406
    Cell Significance Index: 6.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5620
    Cell Significance Index: 55.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4790
    Cell Significance Index: 432.4900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4235
    Cell Significance Index: 1.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3773
    Cell Significance Index: 108.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3703
    Cell Significance Index: 16.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3650
    Cell Significance Index: 73.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3648
    Cell Significance Index: 4.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3397
    Cell Significance Index: 0.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3280
    Cell Significance Index: 12.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3029
    Cell Significance Index: 6.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2964
    Cell Significance Index: 48.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2754
    Cell Significance Index: 18.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2708
    Cell Significance Index: 29.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2601
    Cell Significance Index: 93.3100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2579
    Cell Significance Index: 3.6200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2327
    Cell Significance Index: 1.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2290
    Cell Significance Index: 5.8500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1895
    Cell Significance Index: 0.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1495
    Cell Significance Index: 10.3400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1431
    Cell Significance Index: 1.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1374
    Cell Significance Index: 8.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1295
    Cell Significance Index: 3.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1170
    Cell Significance Index: 7.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0905
    Cell Significance Index: 0.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0837
    Cell Significance Index: 9.7500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0783
    Cell Significance Index: 0.5200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0762
    Cell Significance Index: 0.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0561
    Cell Significance Index: 24.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0500
    Cell Significance Index: 1.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0369
    Cell Significance Index: 2.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0364
    Cell Significance Index: 6.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0359
    Cell Significance Index: 6.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0329
    Cell Significance Index: 0.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0316
    Cell Significance Index: 0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0306
    Cell Significance Index: 0.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0218
    Cell Significance Index: 0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0179
    Cell Significance Index: 27.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0150
    Cell Significance Index: 28.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0143
    Cell Significance Index: 0.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0102
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0069
    Cell Significance Index: 9.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0056
    Cell Significance Index: 3.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0033
    Cell Significance Index: 0.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0040
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0052
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0064
    Cell Significance Index: -4.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0073
    Cell Significance Index: -1.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0093
    Cell Significance Index: -1.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0134
    Cell Significance Index: -0.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0159
    Cell Significance Index: -0.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0175
    Cell Significance Index: -2.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0176
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0184
    Cell Significance Index: -3.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0220
    Cell Significance Index: -0.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0257
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0269
    Cell Significance Index: -1.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0281
    Cell Significance Index: -3.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0293
    Cell Significance Index: -3.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0305
    Cell Significance Index: -1.0000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0310
    Cell Significance Index: -0.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0329
    Cell Significance Index: -0.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0331
    Cell Significance Index: -3.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0340
    Cell Significance Index: -3.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0364
    Cell Significance Index: -4.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0365
    Cell Significance Index: -0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0425
    Cell Significance Index: -0.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0444
    Cell Significance Index: -1.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0457
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0531
    Cell Significance Index: -3.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0532
    Cell Significance Index: -4.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP2E1 is a monooxygenase enzyme that belongs to the cytochrome P450 family. It is a heme-containing enzyme that requires NADPH as a cofactor to catalyze its reactions. The enzyme has a high affinity for oxygen and can catalyze the oxidation of a wide range of substrates, including organic compounds and lipids. CYP2E1 is highly expressed in the liver, where it is located in the endoplasmic reticulum and cytosol. The enzyme is also found in other tissues, including the colon, small intestine, and lung. **Pathways and Functions** CYP2E1 is involved in the metabolism of numerous xenobiotics and endogenous compounds, including: 1. **Xenobiotic metabolism**: CYP2E1 catalyzes the oxidation of halogenated hydrocarbons, benzene, and other environmental pollutants, which can lead to their detoxification and elimination from the body. 2. **Aromatase activity**: CYP2E1 is involved in the metabolism of androgens and estrogens, which can influence reproductive and metabolic processes. 3. **Arachidonic acid epoxygenase activity**: CYP2E1 catalyzes the epoxidation of arachidonic acid, which can lead to the production of eicosanoids, which play a role in inflammation and immune responses. 4. **Biosynthesis of specialized proresolving mediators (SPMs)**: CYP2E1 is involved in the production of SPMs, which are involved in the resolution of inflammation and tissue repair. **Clinical Significance** CYP2E1 has been implicated in various pathological processes, including: 1. **Liver injury**: Overexpression of CYP2E1 has been linked to liver injury and fibrosis, particularly in the context of chronic alcohol consumption. 2. **Cancer**: CYP2E1 has been implicated in the development and progression of various cancers, including liver, lung, and breast cancer. 3. **Metabolic disorders**: CYP2E1 has been linked to metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. 4. **Environmental toxicity**: CYP2E1 has been implicated in the metabolism of environmental pollutants, which can lead to their toxicity and adverse health effects. In conclusion, CYP2E1 is a multifunctional enzyme that plays a crucial role in the metabolism and detoxification of various endogenous and exogenous substances. Its dysregulation has been implicated in various pathological processes, including liver injury, cancer, and metabolic disorders. Further research is needed to fully understand the mechanisms of CYP2E1 and its role in human health and disease.

Genular Protein ID: 50090631

Symbol: CP2E1_HUMAN

Name: 4-nitrophenol 2-hydroxylase

UniProtKB Accession Codes:

P05181 Q5VZD5 Q6NWT9 Q9UK47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 52 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 25 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3782137

Title: Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PubMed ID: 3782137

DOI: 10.1016/s0021-9258(18)66620-7

PubMed ID: 3233219

Title: Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.

PubMed ID: 3233219

DOI: 10.1021/bi00425a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3675576

Title: Purification and characterization of human liver cytochrome P-450-ALC.

PubMed ID: 3675576

DOI: 10.1016/0006-291x(87)91100-4

PubMed ID: 2587619

Title: Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation.

PubMed ID: 2587619

DOI: 10.1159/000138590

PubMed ID: 8031147

Title: Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

PubMed ID: 8031147

DOI: 10.1006/abbi.1994.1280

PubMed ID: 9348445

Title: Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

PubMed ID: 9348445

DOI: 10.1021/tx970048z

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18818195

Title: Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

PubMed ID: 18818195

DOI: 10.1074/jbc.m805999200

PubMed ID: 9058590

Title: Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

PubMed ID: 9058590

PubMed ID: 9918138

Title: Detection and characterization of novel polymorphisms in the CYP2E1 gene.

PubMed ID: 9918138

DOI: 10.1097/00008571-199812000-00011

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

  • Length: 493
  • Mass: 56849
  • Checksum: ED0399E32A005644
  • Sequence:
    • MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL 
AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP 
TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI 
ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA 
EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF 
ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK 
FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC 
IPPRYKLCVI PRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.