Gene CYP2E1 - ENSG00000130649 | NCBI Gene ID: 1571

Details for: CYP2E1

Gene ID: 1571

Symbol: CYP2E1

Ensembl ID: ENSG00000130649

Description: cytochrome P450 family 2 subfamily E member 1

Associated with

Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Paracetamol adme
(R-HSA-9753281)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
4-nitrophenol 2-monooxygenase activity
(GO:0018601)
4-nitrophenol metabolic process
(GO:0018960)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Benzene metabolic process
(GO:0018910)
Carbon tetrachloride metabolic process
(GO:0018885)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Halogenated hydrocarbon metabolic process
(GO:0042197)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Mitochondrial inner membrane
(GO:0005743)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
(GO:0016709)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Oxygen binding
(GO:0019825)
Response to bacterium
(GO:0009617)
Steroid metabolic process
(GO:0008202)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.75
Marker Score: 14802
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.16
Marker Score: 13887
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.92
Marker Score: 8288
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.73
Marker Score: 1849
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.63
Marker Score: 616
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1172
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.5
Marker Score: 1499
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169667
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.21
Marker Score: 376
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4819
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 502
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.01
Marker Score: 1006.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71831
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48056
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.96
Marker Score: 1818
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.82
Marker Score: 7802
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.82
Marker Score: 225
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 616.5
Cell Name: neuron (CL0000540)
Fold Change: 0.78
Marker Score: 3168
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 696
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.74
Marker Score: 45544
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.7
Marker Score: 5977
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.69
Marker Score: 951
Cell Name: interneuron (CL0000099)
Fold Change: 0.67
Marker Score: 305
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.65
Marker Score: 10189
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.64
Marker Score: 984
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 401
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.58
Marker Score: 349
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 456
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.57
Marker Score: 386
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.56
Marker Score: 808
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.55
Marker Score: 121
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.55
Marker Score: 4748
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.53
Marker Score: 2045
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.52
Marker Score: 4935
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.51
Marker Score: 739
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.51
Marker Score: 1442
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.5
Marker Score: 1013
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.49
Marker Score: 18654
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.49
Marker Score: 9654
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.47
Marker Score: 17508
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.47
Marker Score: 3610
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.43
Marker Score: 4471
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.37
Marker Score: 1514
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.36
Marker Score: 152
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.35
Marker Score: 5282
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.34
Marker Score: 971
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.34
Marker Score: 339
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.33
Marker Score: 159
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.33
Marker Score: 138
Cell Name: male germ cell (CL0000015)
Fold Change: 0.32
Marker Score: 92
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.3
Marker Score: 114
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.29
Marker Score: 356
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.29
Marker Score: 610
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.28
Marker Score: 653
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.28
Marker Score: 1157
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.27
Marker Score: 334
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.26
Marker Score: 72
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.26
Marker Score: 82
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.25
Marker Score: 145
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.24
Marker Score: 161
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.23
Marker Score: 190
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.22
Marker Score: 902
Cell Name: peptic cell (CL0000155)
Fold Change: 0.22
Marker Score: 91
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.21
Marker Score: 95
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.21
Marker Score: 67
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.2
Marker Score: 151
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.2
Marker Score: 1547.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.2
Marker Score: 242
Cell Name: astrocyte (CL0000127)
Fold Change: 0.19
Marker Score: 165
Cell Name: memory T cell (CL0000813)
Fold Change: 0.18
Marker Score: 77
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.18
Marker Score: 135
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.17
Marker Score: 3706
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.17
Marker Score: 51
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.17
Marker Score: 351
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.17
Marker Score: 54
Cell Name: melanocyte (CL0000148)
Fold Change: 0.17
Marker Score: 69
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.17
Marker Score: 225
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.17
Marker Score: 95
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.17
Marker Score: 44
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.15
Marker Score: 88
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.15
Marker Score: 103

Hover over a box to see details here...

**Key characteristics:** - The CYP2E1 gene is located on chromosome 17q21.1. - It is a member of the cytochrome P450 family of enzymes. - It is a multi-functional enzyme that can perform a variety of oxidation reactions. - It is involved in the metabolism of a variety of drugs, including paracetamol. **Pathways and functions:** - CYP2E1 enzyme is involved in the metabolism of a variety of drugs, including paracetamol. - It is involved in the metabolism of drugs by catalyzing the oxidation of these drugs to their corresponding polar metabolites. - CYP2E1 is also involved in the metabolism of other drugs, such as caffeine and nicotine. **Clinical significance:** - Mutations in the CYP2E1 gene have been linked to a number of drug-induced liver injuries. - These injuries can be fatal if not treated. - CYP2E1 inhibitors are used to treat drug-induced liver injury. **Conclusion:** The CYP2E1 gene is an important enzyme in the metabolism of drugs. Mutations in this gene can lead to drug-induced liver injury.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

4-nitrophenol 2-hydroxylase

Genular Protein ID: 50090631

Symbol: CP2E1_HUMAN

Name: 4-nitrophenol 2-hydroxylase

UniProtKB Accession Codes:

P05181 Q5VZD5 Q6NWT9 Q9UK47

Database IDs:

Citations:

PubMed ID: 3782137

Title: Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PubMed ID: 3782137

DOI: 10.1016/s0021-9258(18)66620-7

PubMed ID: 3233219

Title: Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.

PubMed ID: 3233219

DOI: 10.1021/bi00425a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3675576

Title: Purification and characterization of human liver cytochrome P-450-ALC.

PubMed ID: 3675576

DOI: 10.1016/0006-291x(87)91100-4

PubMed ID: 2587619

Title: Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation.

PubMed ID: 2587619

DOI: 10.1159/000138590

PubMed ID: 8031147

Title: Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

PubMed ID: 8031147

DOI: 10.1006/abbi.1994.1280

PubMed ID: 9348445

Title: Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

PubMed ID: 9348445

DOI: 10.1021/tx970048z

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18818195

Title: Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

PubMed ID: 18818195

DOI: 10.1074/jbc.m805999200

PubMed ID: 9058590

Title: Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

PubMed ID: 9058590

PubMed ID: 9918138

Title: Detection and characterization of novel polymorphisms in the CYP2E1 gene.

PubMed ID: 9918138

DOI: 10.1097/00008571-199812000-00011

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

Length: 493
Mass: 56849
Checksum: ED0399E32A005644
Sequence:

MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL 
AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP 
TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI 
ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA 
EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF 
ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK 
FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC 
IPPRYKLCVI PRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CYP2E1

Associated with

Cells (max top 100)

Other Information

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. PubMed ID: 3782137

Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. PubMed ID: 3233219

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of human liver cytochrome P-450-ALC. PubMed ID: 3675576

Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation. PubMed ID: 2587619

Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. PubMed ID: 8031147

Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1. PubMed ID: 9348445

Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. PubMed ID: 10553002

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. PubMed ID: 18577768

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. PubMed ID: 18818195

Genetic polymorphism of human CYP2E1: characterization of two variant alleles. PubMed ID: 9058590

Detection and characterization of novel polymorphisms in the CYP2E1 gene. PubMed ID: 9918138

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410