Details for: CYP2E1

Gene ID: 1571

Symbol: CYP2E1

Ensembl ID: ENSG00000130649

Description: cytochrome P450 family 2 subfamily E member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.75
    Marker Score: 14,802
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.16
    Marker Score: 13,887
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.92
    Marker Score: 8,288
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.73
    Marker Score: 1,849
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.63
    Marker Score: 616
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1,499
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,667
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.21
    Marker Score: 376
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.01
    Marker Score: 1,007
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1,818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.82
    Marker Score: 7,802
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.82
    Marker Score: 225
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3,168
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45,544
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.7
    Marker Score: 5,977
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.69
    Marker Score: 951
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.67
    Marker Score: 305
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10,189
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 984
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 401
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.57
    Marker Score: 386
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 808
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.55
    Marker Score: 121
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.55
    Marker Score: 4,748
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.53
    Marker Score: 2,045
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.52
    Marker Score: 4,935
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.51
    Marker Score: 739
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.51
    Marker Score: 1,442
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1,013
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.49
    Marker Score: 18,654
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.49
    Marker Score: 9,654
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.47
    Marker Score: 17,508
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.47
    Marker Score: 3,610
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.43
    Marker Score: 4,471
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.37
    Marker Score: 1,514
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 152
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5,282
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.34
    Marker Score: 971
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.32
    Marker Score: 92
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.29
    Marker Score: 356
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.29
    Marker Score: 610
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 653
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.28
    Marker Score: 1,157
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.27
    Marker Score: 334
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.26
    Marker Score: 72
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.23
    Marker Score: 190
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.22
    Marker Score: 902
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2
    Marker Score: 151
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2
    Marker Score: 1,548
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 242
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 165
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.18
    Marker Score: 77
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 135
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.17
    Marker Score: 3,706
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.17
    Marker Score: 351
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.17
    Marker Score: 225
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 103

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP2E1 is a monooxygenase enzyme that belongs to the cytochrome P450 family. It is a heme-containing enzyme that requires NADPH as a cofactor to catalyze its reactions. The enzyme has a high affinity for oxygen and can catalyze the oxidation of a wide range of substrates, including organic compounds and lipids. CYP2E1 is highly expressed in the liver, where it is located in the endoplasmic reticulum and cytosol. The enzyme is also found in other tissues, including the colon, small intestine, and lung. **Pathways and Functions** CYP2E1 is involved in the metabolism of numerous xenobiotics and endogenous compounds, including: 1. **Xenobiotic metabolism**: CYP2E1 catalyzes the oxidation of halogenated hydrocarbons, benzene, and other environmental pollutants, which can lead to their detoxification and elimination from the body. 2. **Aromatase activity**: CYP2E1 is involved in the metabolism of androgens and estrogens, which can influence reproductive and metabolic processes. 3. **Arachidonic acid epoxygenase activity**: CYP2E1 catalyzes the epoxidation of arachidonic acid, which can lead to the production of eicosanoids, which play a role in inflammation and immune responses. 4. **Biosynthesis of specialized proresolving mediators (SPMs)**: CYP2E1 is involved in the production of SPMs, which are involved in the resolution of inflammation and tissue repair. **Clinical Significance** CYP2E1 has been implicated in various pathological processes, including: 1. **Liver injury**: Overexpression of CYP2E1 has been linked to liver injury and fibrosis, particularly in the context of chronic alcohol consumption. 2. **Cancer**: CYP2E1 has been implicated in the development and progression of various cancers, including liver, lung, and breast cancer. 3. **Metabolic disorders**: CYP2E1 has been linked to metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. 4. **Environmental toxicity**: CYP2E1 has been implicated in the metabolism of environmental pollutants, which can lead to their toxicity and adverse health effects. In conclusion, CYP2E1 is a multifunctional enzyme that plays a crucial role in the metabolism and detoxification of various endogenous and exogenous substances. Its dysregulation has been implicated in various pathological processes, including liver injury, cancer, and metabolic disorders. Further research is needed to fully understand the mechanisms of CYP2E1 and its role in human health and disease.

Genular Protein ID: 50090631

Symbol: CP2E1_HUMAN

Name: 4-nitrophenol 2-hydroxylase

UniProtKB Accession Codes:

P05181 Q5VZD5 Q6NWT9 Q9UK47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 52 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 25 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3782137

Title: Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PubMed ID: 3782137

DOI: 10.1016/s0021-9258(18)66620-7

PubMed ID: 3233219

Title: Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.

PubMed ID: 3233219

DOI: 10.1021/bi00425a019

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3675576

Title: Purification and characterization of human liver cytochrome P-450-ALC.

PubMed ID: 3675576

DOI: 10.1016/0006-291x(87)91100-4

PubMed ID: 2587619

Title: Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation.

PubMed ID: 2587619

DOI: 10.1159/000138590

PubMed ID: 8031147

Title: Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

PubMed ID: 8031147

DOI: 10.1006/abbi.1994.1280

PubMed ID: 9348445

Title: Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

PubMed ID: 9348445

DOI: 10.1021/tx970048z

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18818195

Title: Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

PubMed ID: 18818195

DOI: 10.1074/jbc.m805999200

PubMed ID: 9058590

Title: Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

PubMed ID: 9058590

PubMed ID: 9918138

Title: Detection and characterization of novel polymorphisms in the CYP2E1 gene.

PubMed ID: 9918138

DOI: 10.1097/00008571-199812000-00011

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

  • Length: 493
  • Mass: 56849
  • Checksum: ED0399E32A005644
  • Sequence:
    • MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL 
AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP 
TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI 
ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA 
EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF 
ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK 
FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC 
IPPRYKLCVI PRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.