Details for: CYP2F1

Gene ID: 1572

Symbol: CYP2F1

Ensembl ID: ENSG00000197446

Description: cytochrome P450 family 2 subfamily F member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.43
    Marker Score: 8081
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.2
    Marker Score: 604
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.14
    Marker Score: 2151
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.02
    Marker Score: 1348
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.8
    Marker Score: 521
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.58
    Marker Score: 736
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.38
    Marker Score: 351
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.26
    Marker Score: 620
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.19
    Marker Score: 1387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2415
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1702
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1510
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.76
    Marker Score: 638
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.76
    Marker Score: 5660
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.57
    Marker Score: 165.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1879
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.54
    Marker Score: 317
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8256
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.49
    Marker Score: 380.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 399.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.38
    Marker Score: 661
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.38
    Marker Score: 332
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.36
    Marker Score: 247
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2398
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.35
    Marker Score: 450
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.32
    Marker Score: 611
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.32
    Marker Score: 653
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.31
    Marker Score: 188
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.28
    Marker Score: 201
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.27
    Marker Score: 382
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.25
    Marker Score: 2163
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.24
    Marker Score: 413
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.24
    Marker Score: 308
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 134
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.24
    Marker Score: 210
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 485
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.15
    Marker Score: 783
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 97
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.15
    Marker Score: 158
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.14
    Marker Score: 120
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.14
    Marker Score: 194
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.12
    Marker Score: 380
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 114
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 310.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.1
    Marker Score: 124
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 204.5
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 134
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.07
    Marker Score: 21

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Other Information

## Summary CYP2F1 is a cytochrome P450 enzyme that belongs to the subfamily F of the CYP2 family. It is expressed in various cell types, including secretory cells, tracheobronchial goblet cells, blood vessel endothelial cells, nasal mucosa goblet cells, respiratory goblet cells, duct epithelial cells, mucus secreting cells, granulocyte monocyte progenitor cells, bronchial goblet cells, club cells. ## Key characteristics * CYP2F1 is a multi-functional enzyme that can perform various oxidative and non-oxidative reactions. * It is involved in the metabolism of a wide range of substrates, including fatty acids, xenobiotics, and aromatic compounds. * It is a key regulator of the metabolism of various hormones and drugs. ## Pathways and functions * **Arachidonic acid epoxygenase activity:** CYP2F1 is involved in the metabolism of arachidonic acid, a hormone involved in inflammation and pain sensation. * **Aromatase activity:** CYP2F1 is involved in the metabolism of certain hormones and drugs, including estrogen and testosterone. * **Biological oxidations:** CYP2F1 is involved in a variety of biological oxidations, including the metabolism of hydrogen peroxide, nitric oxide, and glutathione. * **Cyp2e1 reactions:** CYP2F1 is involved in the metabolism of various xenobiotics, including polycyclic aromatic hydrocarbons (PAHs). * **Cytochrome p450 - arranged by substrate type:** CYP2F1 is one of the most abundant and widely expressed CYP450 enzymes. It is involved in a wide range of metabolic reactions, including the metabolism of fatty acids, xenobiotics, and hormones. ## Clinical significance * CYP2F1 gene polymorphisms have been linked to an increased risk of developing certain diseases, including cancer, liver disease, and metabolic disorders. * CYP2F1 inhibitors are being investigated as potential therapeutic agents for these diseases. * CYP2F1 is a promising target for the treatment of drug-induced liver injury.

Genular Protein ID: 1847476192

Symbol: CP2F1_HUMAN

Name: Cytochrome P450 2F1

UniProtKB Accession Codes:

P24903 A7KAU6 A7KAU7 A7KAU8 A7KAU9 A7KAV0 Q32MN5 Q8WWJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1974816

Title: The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.

PubMed ID: 1974816

DOI: 10.1021/bi00475a012

PubMed ID: 11827709

Title: Identification and cross-species comparisons of CYP2F subfamily genes in mammals.

PubMed ID: 11827709

DOI: 10.1016/s0027-5107(01)00274-3

PubMed ID: 17327131

Title: Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.

PubMed ID: 17327131

DOI: 10.1016/j.mrfmmm.2007.01.007

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619884

Title: Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.

PubMed ID: 8619884

DOI: 10.1016/0006-2952(95)02184-1

PubMed ID: 8558432

Title: Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.

PubMed ID: 8558432

PubMed ID: 10383923

Title: Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.

PubMed ID: 10383923

Sequence Information:

  • Length: 491
  • Mass: 55501
  • Checksum: D8022271FC0B6D06
  • Sequence:
    • MDSISTAILL LLLALVCLLL TLSSRDKGKL PPGPRPLSIL GNLLLLCSQD MLTSLTKLSK 
EYGSMYTVHL GPRRVVVLSG YQAVKEALVD QGEEFSGRGD YPAFFNFTKG NGIAFSSGDR 
WKVLRQFSIQ ILRNFGMGKR SIEERILEEG SFLLAELRKT EGEPFDPTFV LSRSVSNIIC 
SVLFGSRFDY DDERLLTIIR LINDNFQIMS SPWGELYDIF PSLLDWVPGP HQRIFQNFKC 
LRDLIAHSVH DHQASLDPRS PRDFIQCFLT KMAEEKEDPL SHFHMDTLLM TTHNLLFGGT 
KTVSTTLHHA FLALMKYPKV QARVQEEIDL VVGRARLPAL KDRAAMPYTD AVIHEVQRFA 
DIIPMNLPHR VTRDTAFRGF LIPKGTDVIT LLNTVHYDPS QFLTPQEFNP EHFLDANQSF 
KKSPAFMPFS AGRRLCLGES LARMELFLYL TAILQSFSLQ PLGAPEDIDL TPLSSGLGNL 
PRPFQLCLRP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.