Details for: CYP2F1

Gene ID: 1572

Symbol: CYP2F1

Ensembl ID: ENSG00000197446

Description: cytochrome P450 family 2 subfamily F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 9.0128
    Cell Significance Index: 92.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.6773
    Cell Significance Index: -1.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.6676
    Cell Significance Index: 25.8000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.1099
    Cell Significance Index: 9.1800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.2929
    Cell Significance Index: 2.5200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2662
    Cell Significance Index: 2.0100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1796
    Cell Significance Index: 2.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1704
    Cell Significance Index: 2.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1668
    Cell Significance Index: 2.3900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1494
    Cell Significance Index: 1.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0627
    Cell Significance Index: 0.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0346
    Cell Significance Index: 0.2300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0217
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0098
    Cell Significance Index: 7.4400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0084
    Cell Significance Index: 0.1100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0030
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0069
    Cell Significance Index: -1.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0070
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0072
    Cell Significance Index: -1.0400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0072
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0074
    Cell Significance Index: -0.8600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0113
    Cell Significance Index: -1.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0137
    Cell Significance Index: -0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0142
    Cell Significance Index: -1.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0144
    Cell Significance Index: -0.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0168
    Cell Significance Index: -0.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0188
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0206
    Cell Significance Index: -0.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0208
    Cell Significance Index: -1.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0209
    Cell Significance Index: -1.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0216
    Cell Significance Index: -1.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0217
    Cell Significance Index: -1.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0223
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0225
    Cell Significance Index: -0.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0228
    Cell Significance Index: -0.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0230
    Cell Significance Index: -0.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0241
    Cell Significance Index: -0.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0251
    Cell Significance Index: -0.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0281
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0284
    Cell Significance Index: -0.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0284
    Cell Significance Index: -1.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0289
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0303
    Cell Significance Index: -0.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0309
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0312
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0319
    Cell Significance Index: -1.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0323
    Cell Significance Index: -1.8100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0348
    Cell Significance Index: -0.1900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0359
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0361
    Cell Significance Index: -0.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0367
    Cell Significance Index: -1.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0386
    Cell Significance Index: -1.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0400
    Cell Significance Index: -1.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0408
    Cell Significance Index: -1.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0446
    Cell Significance Index: -1.2900
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.0448
    Cell Significance Index: -0.4400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0449
    Cell Significance Index: -0.4500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0462
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0463
    Cell Significance Index: -1.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0467
    Cell Significance Index: -0.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0499
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0502
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0505
    Cell Significance Index: -0.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0509
    Cell Significance Index: -1.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0510
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0522
    Cell Significance Index: -1.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0527
    Cell Significance Index: -1.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0539
    Cell Significance Index: -0.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0547
    Cell Significance Index: -1.4600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0554
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0556
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0562
    Cell Significance Index: -1.6500
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.0570
    Cell Significance Index: -0.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0577
    Cell Significance Index: -1.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0579
    Cell Significance Index: -1.2500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0592
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CYP2F1 is a cytochrome P450 enzyme, a family of enzymes responsible for the metabolism of a wide range of substances, including drugs, hormones, and toxins. This enzyme is specifically expressed in various cell types, including secretory cells, tracheobronchial goblet cells, blood vessel endothelial cells, and granulocyte monocyte progenitor cells. The expression of CYP2F1 is also observed in other tissues, such as the nasal mucosa, respiratory goblet cells, and duct epithelial cells. **Pathways and Functions:** CYP2F1 is involved in several metabolic pathways, including: 1. **Arachidonic acid epoxygenase activity:** CYP2F1 is responsible for the epoxygenation of arachidonic acid, a key step in the production of epoxyeicosatrienoic acids (EETs), which have anti-inflammatory properties. 2. **Aromatase activity:** CYP2F1 can also participate in the aromatization of androgens, contributing to the regulation of sex hormone metabolism. 3. **Oxidoreductase activity:** As a monooxygenase enzyme, CYP2F1 catalyzes the incorporation of one atom of oxygen into substrates, facilitating the metabolism of various compounds. 4. **Xenobiotic metabolic process:** CYP2F1 plays a crucial role in the detoxification of xenobiotics, including environmental pollutants and pharmaceuticals. **Clinical Significance:** CYP2F1 has significant implications for various diseases and conditions, including: 1. **Respiratory diseases:** Alterations in CYP2F1 expression have been linked to respiratory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). 2. **Cancer:** CYP2F1 has been implicated in the metabolism of carcinogens and the regulation of cancer cell growth and survival. 3. **Infectious diseases:** CYP2F1 is involved in the metabolism of antibiotics and antiviral compounds, highlighting its potential role in the treatment of infections. 4. **Toxicity:** Dysregulation of CYP2F1 expression can lead to increased susceptibility to toxic substances, underscoring the importance of this enzyme in maintaining cellular homeostasis. In conclusion, CYP2F1 is a multifaceted enzyme that plays a critical role in various biological processes, including metabolism, immune response, and xenobiotic detoxification. Further research on this enzyme will provide valuable insights into its mechanisms of action and its potential applications in the prevention and treatment of diseases.

Genular Protein ID: 1847476192

Symbol: CP2F1_HUMAN

Name: Cytochrome P450 2F1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1974816

Title: The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.

PubMed ID: 1974816

DOI: 10.1021/bi00475a012

PubMed ID: 11827709

Title: Identification and cross-species comparisons of CYP2F subfamily genes in mammals.

PubMed ID: 11827709

DOI: 10.1016/s0027-5107(01)00274-3

PubMed ID: 17327131

Title: Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.

PubMed ID: 17327131

DOI: 10.1016/j.mrfmmm.2007.01.007

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619884

Title: Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.

PubMed ID: 8619884

DOI: 10.1016/0006-2952(95)02184-1

PubMed ID: 8558432

Title: Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.

PubMed ID: 8558432

PubMed ID: 10383923

Title: Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.

PubMed ID: 10383923

Sequence Information:

  • Length: 491
  • Mass: 55501
  • Checksum: D8022271FC0B6D06
  • Sequence:
  • MDSISTAILL LLLALVCLLL TLSSRDKGKL PPGPRPLSIL GNLLLLCSQD MLTSLTKLSK 
    EYGSMYTVHL GPRRVVVLSG YQAVKEALVD QGEEFSGRGD YPAFFNFTKG NGIAFSSGDR 
    WKVLRQFSIQ ILRNFGMGKR SIEERILEEG SFLLAELRKT EGEPFDPTFV LSRSVSNIIC 
    SVLFGSRFDY DDERLLTIIR LINDNFQIMS SPWGELYDIF PSLLDWVPGP HQRIFQNFKC 
    LRDLIAHSVH DHQASLDPRS PRDFIQCFLT KMAEEKEDPL SHFHMDTLLM TTHNLLFGGT 
    KTVSTTLHHA FLALMKYPKV QARVQEEIDL VVGRARLPAL KDRAAMPYTD AVIHEVQRFA 
    DIIPMNLPHR VTRDTAFRGF LIPKGTDVIT LLNTVHYDPS QFLTPQEFNP EHFLDANQSF 
    KKSPAFMPFS AGRRLCLGES LARMELFLYL TAILQSFSLQ PLGAPEDIDL TPLSSGLGNL 
    PRPFQLCLRP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.