Details for: CYP2J2

Gene ID: 1573

Symbol: CYP2J2

Ensembl ID: ENSG00000134716

Description: cytochrome P450 family 2 subfamily J member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.3403
    Cell Significance Index: -10.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.2641
    Cell Significance Index: -10.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.3658
    Cell Significance Index: -8.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.3661
    Cell Significance Index: -9.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6621
    Cell Significance Index: -10.6800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 4.7250
    Cell Significance Index: 48.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.6388
    Cell Significance Index: 240.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4086
    Cell Significance Index: -11.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1277
    Cell Significance Index: 83.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4039
    Cell Significance Index: 108.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9189
    Cell Significance Index: 147.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8517
    Cell Significance Index: 53.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2917
    Cell Significance Index: 1166.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2650
    Cell Significance Index: 75.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1355
    Cell Significance Index: 24.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0471
    Cell Significance Index: 113.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8127
    Cell Significance Index: 132.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8096
    Cell Significance Index: 19.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6342
    Cell Significance Index: 43.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6170
    Cell Significance Index: 122.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5726
    Cell Significance Index: 8.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3775
    Cell Significance Index: 12.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3775
    Cell Significance Index: 8.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3746
    Cell Significance Index: 6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3184
    Cell Significance Index: 6.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3129
    Cell Significance Index: 4.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2943
    Cell Significance Index: 7.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2544
    Cell Significance Index: 31.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2228
    Cell Significance Index: 5.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2135
    Cell Significance Index: 24.8800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1978
    Cell Significance Index: 1.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1612
    Cell Significance Index: 15.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1587
    Cell Significance Index: 5.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1564
    Cell Significance Index: 28.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1171
    Cell Significance Index: 22.2800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0775
    Cell Significance Index: 1.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0724
    Cell Significance Index: 1.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0676
    Cell Significance Index: 3.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0508
    Cell Significance Index: 0.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0358
    Cell Significance Index: 19.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0215
    Cell Significance Index: 1.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0074
    Cell Significance Index: 0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0034
    Cell Significance Index: 0.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -15.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0098
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0108
    Cell Significance Index: -14.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0232
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0260
    Cell Significance Index: -11.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0310
    Cell Significance Index: -1.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0334
    Cell Significance Index: -14.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0336
    Cell Significance Index: -9.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0352
    Cell Significance Index: -4.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0356
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0381
    Cell Significance Index: -4.3700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0400
    Cell Significance Index: -0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0416
    Cell Significance Index: -8.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0459
    Cell Significance Index: -6.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0585
    Cell Significance Index: -8.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0601
    Cell Significance Index: -12.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0613
    Cell Significance Index: -10.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0663
    Cell Significance Index: -3.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0755
    Cell Significance Index: -1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0849
    Cell Significance Index: -10.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1012
    Cell Significance Index: -11.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1056
    Cell Significance Index: -11.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1066
    Cell Significance Index: -1.2200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1105
    Cell Significance Index: -1.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1150
    Cell Significance Index: -1.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1191
    Cell Significance Index: -3.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1256
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1261
    Cell Significance Index: -9.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1416
    Cell Significance Index: -7.3800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1522
    Cell Significance Index: -2.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1530
    Cell Significance Index: -9.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1542
    Cell Significance Index: -10.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1649
    Cell Significance Index: -7.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1775
    Cell Significance Index: -11.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1798
    Cell Significance Index: -11.0500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1918
    Cell Significance Index: -1.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1931
    Cell Significance Index: -2.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1960
    Cell Significance Index: -11.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1982
    Cell Significance Index: -14.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2036
    Cell Significance Index: -10.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2093
    Cell Significance Index: -7.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2505
    Cell Significance Index: -11.0800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2742
    Cell Significance Index: -1.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2859
    Cell Significance Index: -7.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2949
    Cell Significance Index: -10.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2966
    Cell Significance Index: -11.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3004
    Cell Significance Index: -10.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3015
    Cell Significance Index: -7.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP2J2 is a member of the cytochrome P450 superfamily, characterized by its ability to catalyze the epoxygenation of arachidonic acid. The gene is highly expressed in various tissues, including the kidney, placenta, heart, and respiratory epithelium. CYP2J2 is also notable for its ability to regulate cardiac function, with decreased expression levels associated with cardiac hypertrophy and heart failure. **Pathways and Functions** CYP2J2 is involved in several key pathways, including: 1. **Arachidonic acid metabolism**: CYP2J2 catalyzes the epoxygenation of arachidonic acid, resulting in the production of EETs and DHETs. 2. **Epoxygenase p450 pathway**: CYP2J2 is a key enzyme in this pathway, which involves the oxidation of arachidonic acid to form EETs and DHETs. 3. **Fatty acid metabolic process**: CYP2J2 is involved in the metabolism of fatty acids, including arachidonic acid, resulting in the production of EETs and DHETs. 4. **Regulation of heart contraction**: CYP2J2 has been shown to regulate cardiac function, with decreased expression levels associated with cardiac hypertrophy and heart failure. **Clinical Significance** CYP2J2 has been implicated in various diseases and disorders, including: 1. **Cardiovascular disease**: Decreased expression levels of CYP2J2 have been associated with cardiac hypertrophy and heart failure. 2. **Cancer**: CYP2J2 has been shown to regulate cancer cell growth and metastasis. 3. **Inflammatory disorders**: CYP2J2 has been implicated in the regulation of inflammation, with decreased expression levels associated with inflammatory diseases. 4. **Neurological disorders**: CYP2J2 has been shown to regulate neuroinflammation and neurodegenerative diseases. In summary, CYP2J2 is a critical component of the cytochrome P450 enzyme family, involved in the metabolism and regulation of arachidonic acid and various biological processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of CYP2J2 in maintaining physiological homeostasis.

Genular Protein ID: 93374357

Symbol: CP2J2_HUMAN

Name: Cytochrome P450 2J2

UniProtKB Accession Codes:

P51589 B2RD33 Q8TF13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 3 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 60 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8631948

Title: Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.

PubMed ID: 8631948

DOI: 10.1074/jbc.271.7.3460

PubMed ID: 12386130

Title: Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.

PubMed ID: 12386130

DOI: 10.1124/dmd.30.11.1240

PubMed ID: 11901223

Title: Cloning of CYP2J2 gene and identification of functional polymorphisms.

PubMed ID: 11901223

DOI: 10.1124/mol.61.4.840

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19737933

Title: Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.

PubMed ID: 19737933

DOI: 10.1074/jbc.m109.025627

PubMed ID: 19923256

Title: Identification of novel substrates for human cytochrome P450 2J2.

PubMed ID: 19923256

DOI: 10.1124/dmd.109.030270

PubMed ID: 23959307

Title: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

PubMed ID: 23959307

DOI: 10.1128/aac.00843-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

Sequence Information:

  • Length: 502
  • Mass: 57611
  • Checksum: B5F006581E249EC0
  • Sequence:
    • MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL PFLGNFFLVD 
FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA LIHMDQNFGN RPVTPMREHI 
FKKNGLIMSS GQAWKEQRRF TLTALRNFGL GKKSLEERIQ EEAQHLTEAI KEENGQPFDP 
HFKINNAVSN IICSITFGER FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL 
PGPHQTLFSN WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ PSTAARESMP 
YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM ILTNLTALHR DPTEWATPDT 
FNPDHFLENG QFKKREAFMP FSIGKRACLG EQLARTELFI FFTSLMQKFT FRPPNNEKLS 
LKFRMGITIS PVSHRLCAVP QV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.