CYP2J2 | ENSG00000134716 | NCBI 1573

Details for: CYP2J2

Gene ID: 1573

Symbol: CYP2J2

Ensembl ID: ENSG00000134716

Description: cytochrome P450 family 2 subfamily J member 2

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Fatty acid metabolism
(R-HSA-8978868)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-HSA-2142670)
Xenobiotics
(R-HSA-211981)
Arachidonic acid 5,6-epoxygenase activity
(GO:0106301)
Arachidonic acid 11,12-epoxygenase activity
(GO:0008405)
Arachidonic acid 14,15-epoxygenase activity
(GO:0008404)
Arachidonic acid epoxygenase activity
(GO:0008392)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Epoxygenase p450 pathway
(GO:0019373)
Extracellular exosome
(GO:0070062)
Fatty acid metabolic process
(GO:0006631)
Heme binding
(GO:0020037)
Hydroperoxy icosatetraenoate isomerase activity
(GO:0106255)
Icosanoid metabolic process
(GO:0006690)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Isomerase activity
(GO:0016853)
Linoleic acid epoxygenase activity
(GO:0071614)
Linoleic acid metabolic process
(GO:0043651)
Monooxygenase activity
(GO:0004497)
Organic acid metabolic process
(GO:0006082)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Regulation of heart contraction
(GO:0008016)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2J2

Genular Protein ID: 93374357

Symbol: CP2J2_HUMAN

Name: Cytochrome P450 2J2

UniProtKB Accession Codes:

P51589 B2RD33 Q8TF13

Database IDs:

Citations:

PubMed ID: 8631948

Title: Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.

PubMed ID: 8631948

DOI: 10.1074/jbc.271.7.3460

PubMed ID: 12386130

Title: Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.

PubMed ID: 12386130

DOI: 10.1124/dmd.30.11.1240

PubMed ID: 11901223

Title: Cloning of CYP2J2 gene and identification of functional polymorphisms.

PubMed ID: 11901223

DOI: 10.1124/mol.61.4.840

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19737933

Title: Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.

PubMed ID: 19737933

DOI: 10.1074/jbc.m109.025627

PubMed ID: 19923256

Title: Identification of novel substrates for human cytochrome P450 2J2.

PubMed ID: 19923256

DOI: 10.1124/dmd.109.030270

PubMed ID: 23959307

Title: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

PubMed ID: 23959307

DOI: 10.1128/aac.00843-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

Sequence Information:

Length: 502
Mass: 57611
Checksum: B5F006581E249EC0
Sequence:

MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL PFLGNFFLVD 
FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA LIHMDQNFGN RPVTPMREHI 
FKKNGLIMSS GQAWKEQRRF TLTALRNFGL GKKSLEERIQ EEAQHLTEAI KEENGQPFDP 
HFKINNAVSN IICSITFGER FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL 
PGPHQTLFSN WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ PSTAARESMP 
YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM ILTNLTALHR DPTEWATPDT 
FNPDHFLENG QFKKREAFMP FSIGKRACLG EQLARTELFI FFTSLMQKFT FRPPNNEKLS 
LKFRMGITIS PVSHRLCAVP QV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2J2

Associated with

Other Information

Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. PubMed ID: 8631948

Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. PubMed ID: 12386130

Cloning of CYP2J2 gene and identification of functional polymorphisms. PubMed ID: 11901223

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. PubMed ID: 19737933

Identification of novel substrates for human cytochrome P450 2J2. PubMed ID: 19923256

CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. PubMed ID: 23959307

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576