Details for: CYP2J2

Gene ID: 1573

Symbol: CYP2J2

Ensembl ID: ENSG00000134716

Description: cytochrome P450 family 2 subfamily J member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.31
    Marker Score: 4788
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7
    Marker Score: 6669
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.67
    Marker Score: 5947
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.49
    Marker Score: 996
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.48
    Marker Score: 33041
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169070
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.35
    Marker Score: 391
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.17
    Marker Score: 322
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.16
    Marker Score: 24666
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.13
    Marker Score: 1669
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17508
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.03
    Marker Score: 1594
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.01
    Marker Score: 2410
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5165
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.88
    Marker Score: 4247
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.87
    Marker Score: 662
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1619
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 652.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.82
    Marker Score: 6079
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.77
    Marker Score: 3316
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.73
    Marker Score: 342
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.72
    Marker Score: 716
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.7
    Marker Score: 346
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7
    Marker Score: 4491
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2863
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.66
    Marker Score: 2159
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.64
    Marker Score: 751
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.61
    Marker Score: 503
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1239
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.61
    Marker Score: 176
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6
    Marker Score: 3252
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.59
    Marker Score: 150
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.58
    Marker Score: 502
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.57
    Marker Score: 1346
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.56
    Marker Score: 898
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.54
    Marker Score: 1698
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.54
    Marker Score: 4632
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.49
    Marker Score: 901
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1136
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.47
    Marker Score: 176
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.47
    Marker Score: 578
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.44
    Marker Score: 290
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.42
    Marker Score: 353
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 402.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.4
    Marker Score: 3499
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 271
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.39
    Marker Score: 1341
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.37
    Marker Score: 2881
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.37
    Marker Score: 236
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 210
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.34
    Marker Score: 637
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.33
    Marker Score: 317
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.33
    Marker Score: 811
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.33
    Marker Score: 79
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.32
    Marker Score: 200
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.31
    Marker Score: 77
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 147
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 194
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.29
    Marker Score: 519
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 128
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.27
    Marker Score: 606
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.26
    Marker Score: 277
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.26
    Marker Score: 103
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.25
    Marker Score: 92
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 688
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.24
    Marker Score: 253
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.24
    Marker Score: 254
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.23
    Marker Score: 1224
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 152
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.22
    Marker Score: 2983
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.22
    Marker Score: 855
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.22
    Marker Score: 283
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.22
    Marker Score: 134
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 47
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.21
    Marker Score: 101

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Other Information

**Key characteristics:** - The CYP2J2 gene is located on chromosome 19p13.3. - It is a single gene with a size of approximately 4.3 kb. - The protein encoded by CYP2J2 is a transmembrane protein with a molecular weight of approximately 550 kDa. - CYP2J2 is a member of the cytochrome P450 family of enzymes, which are involved in a wide range of metabolic pathways. **Pathways and functions:** - CYP2J2 is involved in the metabolism of a variety of endogenous and exogenous compounds, including fatty acids, cholesterol, and bile acids. - It is involved in the metabolism of drugs, such as warfarin and methotrexate. - CYP2J2 is also involved in the metabolism of hormones, such as estrogen and testosterone. **Clinical significance:** - Mutations in the CYP2J2 gene have been linked to a number of human diseases, including liver disease, cardiovascular disease, and cancer. - CYP2J2 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - CYP2J2 is a highly conserved protein, with sequences similar to CYP2J2 genes found in other mammals. - The CYP2J2 gene is also involved in the regulation of inflammation. - CYP2J2 is a promising target for the development of new drugs for a variety of diseases.

Genular Protein ID: 93374357

Symbol: CP2J2_HUMAN

Name: Cytochrome P450 2J2

UniProtKB Accession Codes:

P51589 B2RD33 Q8TF13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 3 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 60 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8631948

Title: Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.

PubMed ID: 8631948

DOI: 10.1074/jbc.271.7.3460

PubMed ID: 12386130

Title: Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.

PubMed ID: 12386130

DOI: 10.1124/dmd.30.11.1240

PubMed ID: 11901223

Title: Cloning of CYP2J2 gene and identification of functional polymorphisms.

PubMed ID: 11901223

DOI: 10.1124/mol.61.4.840

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19737933

Title: Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.

PubMed ID: 19737933

DOI: 10.1074/jbc.m109.025627

PubMed ID: 19923256

Title: Identification of novel substrates for human cytochrome P450 2J2.

PubMed ID: 19923256

DOI: 10.1124/dmd.109.030270

PubMed ID: 23959307

Title: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

PubMed ID: 23959307

DOI: 10.1128/aac.00843-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

Sequence Information:

  • Length: 502
  • Mass: 57611
  • Checksum: B5F006581E249EC0
  • Sequence:
    • MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL PFLGNFFLVD 
FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA LIHMDQNFGN RPVTPMREHI 
FKKNGLIMSS GQAWKEQRRF TLTALRNFGL GKKSLEERIQ EEAQHLTEAI KEENGQPFDP 
HFKINNAVSN IICSITFGER FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL 
PGPHQTLFSN WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ PSTAARESMP 
YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM ILTNLTALHR DPTEWATPDT 
FNPDHFLENG QFKKREAFMP FSIGKRACLG EQLARTELFI FFTSLMQKFT FRPPNNEKLS 
LKFRMGITIS PVSHRLCAVP QV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.