Details for: CYP3A4

Gene ID: 1576

Symbol: CYP3A4

Ensembl ID: ENSG00000160868

Description: cytochrome P450 family 3 subfamily A member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 19.3976
    Cell Significance Index: 51.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 17.3040
    Cell Significance Index: 291.4900
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 8.4227
    Cell Significance Index: 4.2300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.4312
    Cell Significance Index: 41.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2808
    Cell Significance Index: -6.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1787
    Cell Significance Index: 414.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.6714
    Cell Significance Index: 24.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5657
    Cell Significance Index: 45.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4249
    Cell Significance Index: 30.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2930
    Cell Significance Index: 31.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0307
    Cell Significance Index: 61.8800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9412
    Cell Significance Index: 5.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8663
    Cell Significance Index: 140.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7122
    Cell Significance Index: 77.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6915
    Cell Significance Index: 68.4100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.6719
    Cell Significance Index: 1.8000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.5472
    Cell Significance Index: 4.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4996
    Cell Significance Index: 34.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4329
    Cell Significance Index: 9.2200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.3524
    Cell Significance Index: 3.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3276
    Cell Significance Index: 295.8200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.2989
    Cell Significance Index: 1.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2678
    Cell Significance Index: 53.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1528
    Cell Significance Index: 3.8200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1262
    Cell Significance Index: 0.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1006
    Cell Significance Index: 4.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0829
    Cell Significance Index: 0.5500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0705
    Cell Significance Index: 0.6700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0435
    Cell Significance Index: 0.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0415
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0396
    Cell Significance Index: 1.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0279
    Cell Significance Index: 5.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0226
    Cell Significance Index: 0.5800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0131
    Cell Significance Index: 0.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0129
    Cell Significance Index: 0.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0024
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0017
    Cell Significance Index: -0.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0034
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0062
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0092
    Cell Significance Index: -5.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0138
    Cell Significance Index: -0.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0197
    Cell Significance Index: -0.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0200
    Cell Significance Index: -1.0400
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0203
    Cell Significance Index: -0.1800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0212
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0222
    Cell Significance Index: -2.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0238
    Cell Significance Index: -3.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0265
    Cell Significance Index: -1.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0323
    Cell Significance Index: -3.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0335
    Cell Significance Index: -0.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0347
    Cell Significance Index: -6.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0361
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0378
    Cell Significance Index: -1.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0384
    Cell Significance Index: -0.5500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0429
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0477
    Cell Significance Index: -6.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0484
    Cell Significance Index: -1.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0487
    Cell Significance Index: -4.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0530
    Cell Significance Index: -2.1700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0532
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0546
    Cell Significance Index: -4.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0574
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0587
    Cell Significance Index: -6.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0595
    Cell Significance Index: -7.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0598
    Cell Significance Index: -2.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0653
    Cell Significance Index: -0.5900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0673
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0705
    Cell Significance Index: -4.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0713
    Cell Significance Index: -1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0714
    Cell Significance Index: -4.3900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0746
    Cell Significance Index: -0.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0774
    Cell Significance Index: -1.0700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0802
    Cell Significance Index: -0.4200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0817
    Cell Significance Index: -0.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0849
    Cell Significance Index: -2.1200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0854
    Cell Significance Index: -1.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0927
    Cell Significance Index: -7.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0955
    Cell Significance Index: -0.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0960
    Cell Significance Index: -1.5400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0970
    Cell Significance Index: -1.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1028
    Cell Significance Index: -3.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1030
    Cell Significance Index: -1.1700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1041
    Cell Significance Index: -1.1500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1053
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1059
    Cell Significance Index: -1.4500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1062
    Cell Significance Index: -1.0400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1063
    Cell Significance Index: -1.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP3A4 exhibits several key characteristics that enable it to perform its functions effectively: 1. **Monooxygenase activity**: CYP3A4 catalyzes the incorporation of one atom of oxygen into a substrate, resulting in the formation of a hydroxyl group. 2. **High substrate specificity**: CYP3A4 has a broad substrate specificity, metabolizing a wide range of compounds, including drugs, steroids, and endogenous compounds. 3. **Enzyme induction and inhibition**: CYP3A4 can be induced or inhibited by various substances, affecting its expression and activity. 4. **Regulation by nuclear receptors**: CYP3A4 expression is regulated by nuclear receptors, such as the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). **Pathways and Functions** CYP3A4 is involved in various metabolic pathways, including: 1. **Phase I metabolism**: CYP3A4 catalyzes the oxidation of lipids, steroids, and other substrates, resulting in the formation of hydroxylated metabolites. 2. **Phase II metabolism**: CYP3A4 can also catalyze the conjugation of hydroxylated metabolites with glucuronic acid, sulfate, or other molecules, resulting in the formation of more water-soluble metabolites. 3. **Detoxification**: CYP3A4 plays a crucial role in the detoxification of xenobiotics, including drugs and environmental toxins. 4. **Endogenous compound metabolism**: CYP3A4 metabolizes endogenous compounds, such as steroids and fatty acids. **Clinical Significance** CYP3A4 has significant clinical implications, particularly in the context of: 1. **Drug metabolism**: CYP3A4 is involved in the metabolism of many drugs, including statins, antiretroviral therapies, and immunosuppressants, which can lead to interactions and adverse effects. 2. **Cancer treatment**: CYP3A4 can metabolize chemotherapeutic agents, affecting their efficacy and toxicity. 3. **Xenobiotic exposure**: CYP3A4 plays a crucial role in the detoxification of xenobiotics, including environmental pollutants and heavy metals. 4. **Genetic variations**: Genetic variations in the CYP3A4 gene can affect its expression and activity, leading to variations in drug metabolism and sensitivity. In conclusion, CYP3A4 is a vital enzyme involved in the metabolism of a wide range of substances, including drugs, xenobiotics, and endogenous compounds. Its clinical significance is evident in various areas, including drug metabolism, cancer treatment, xenobiotic exposure, and genetic variations. Understanding the functions and regulation of CYP3A4 is essential for optimizing drug therapy and minimizing adverse effects.

Genular Protein ID: 3663061466

Symbol: CP3A4_HUMAN

Name: 1,8-cineole 2-exo-monooxygenase

UniProtKB Accession Codes:

P08684 P05184 Q16757 Q9UK50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 5 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 78 PDBsum 78 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 100 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3460094

Title: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

PubMed ID: 3460094

DOI: 10.1073/pnas.83.14.5311

PubMed ID: 3267210

Title: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.

PubMed ID: 3267210

DOI: 10.1089/dna.1988.7.79

PubMed ID: 3464943

Title: Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

PubMed ID: 3464943

DOI: 10.1073/pnas.83.21.8064

PubMed ID: 2563251

Title: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.

PubMed ID: 2563251

DOI: 10.1007/bf00293896

PubMed ID: 2463251

Title: Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.

PubMed ID: 2463251

DOI: 10.1016/s0021-9258(19)85029-9

PubMed ID: 10322772

Title: Establishment of transgenic cell line CHL-3A4 and its metabolic activation.

PubMed ID: 10322772

PubMed ID: 11266076

Title: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

PubMed ID: 11266076

DOI: 10.1097/00008571-200103000-00002

PubMed ID: 11181494

Title: Novel mutations of CYP3A4 in Chinese.

PubMed ID: 11181494

PubMed ID: 3243766

Title: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.

PubMed ID: 3243766

DOI: 10.1093/oxfordjournals.jbchem.a122582

PubMed ID: 3898085

Title: Identification of an inducible form of cytochrome P-450 in human liver.

PubMed ID: 3898085

DOI: 10.1073/pnas.82.18.6310

PubMed ID: 2732228

Title: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

PubMed ID: 2732228

DOI: 10.1016/s0021-9258(18)81632-5

PubMed ID: 8035341

Title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

PubMed ID: 8035341

PubMed ID: 7894497

Title: CYP3A gene expression in human gut epithelium.

PubMed ID: 7894497

DOI: 10.1097/00008571-199410000-00003

PubMed ID: 8968357

Title: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.

PubMed ID: 8968357

PubMed ID: 9435160

Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

PubMed ID: 9435160

PubMed ID: 10759686

Title: Relative contribution of cytochromes P-450 and flavin-containing monooxygenases to the metabolism of albendazole by human liver microsomes.

PubMed ID: 10759686

DOI: 10.1046/j.1365-2125.2000.00170.x

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 11159812

Title: Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.

PubMed ID: 11159812

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 11726664

Title: Intergenic mRNA molecules resulting from trans-splicing.

PubMed ID: 11726664

DOI: 10.1074/jbc.m109175200

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15373842

Title: Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.

PubMed ID: 15373842

DOI: 10.1111/j.1432-1033.2004.04339.x

PubMed ID: 15764715

Title: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.

PubMed ID: 15764715

DOI: 10.1124/dmd.104.003327

PubMed ID: 19094056

Title: ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

PubMed ID: 19094056

DOI: 10.1111/j.1471-4159.2008.05720.x

PubMed ID: 18545703

Title: Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.

PubMed ID: 18545703

DOI: 10.1371/journal.pone.0002337

PubMed ID: 19103148

Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

PubMed ID: 19103148

DOI: 10.1016/j.abb.2008.12.001

PubMed ID: 19359404

Title: Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

PubMed ID: 19359404

DOI: 10.1124/dmd.109.027011

PubMed ID: 20702771

Title: Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide.

PubMed ID: 20702771

DOI: 10.1124/dmd.110.033712

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 21490593

Title: Evaluation of 6beta-hydroxycortisol, 6beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.

PubMed ID: 21490593

DOI: 10.1038/clpt.2011.53

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 22773874

Title: Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.

PubMed ID: 22773874

DOI: 10.1074/jbc.m112.390047

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26988023

Title: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

PubMed ID: 26988023

DOI: 10.1038/ncomms11030

PubMed ID: 15258162

Title: The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.

PubMed ID: 15258162

DOI: 10.1074/jbc.c400293200

PubMed ID: 15256616

Title: Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

PubMed ID: 15256616

DOI: 10.1126/science.1099736

PubMed ID: 10668853

Title: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

PubMed ID: 10668853

DOI: 10.1067/mcp.2000.104391

PubMed ID: 11714865

Title: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

PubMed ID: 11714865

PubMed ID: 11470997

Title: Identification and functional characterization of eight CYP3A4 protein variants.

PubMed ID: 11470997

DOI: 10.1097/00008571-200107000-00008

PubMed ID: 11875366

Title: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.

PubMed ID: 11875366

DOI: 10.1097/00008571-200203000-00006

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 29461981

Title: CYP3A4 mutation causes vitamin D-dependent rickets type 3.

PubMed ID: 29461981

DOI: 10.1172/jci98680

Sequence Information:

  • Length: 503
  • Mass: 57343
  • Checksum: 38ED122BF89F74F7
  • Sequence:
    • MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF 
DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI 
AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS 
MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV 
FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI 
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV 
NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS 
KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG 
GLLQPEKPVV LKVESRDGTV SGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.