Details for: CYP3A4
Associated with
Other Information
Genular Protein ID: 3663061466
Symbol: CP3A4_HUMAN
Name: 1,8-cineole 2-exo-monooxygenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3460094
Title: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
PubMed ID: 3460094
PubMed ID: 3267210
Title: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
PubMed ID: 3267210
PubMed ID: 3464943
Title: Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.
PubMed ID: 3464943
PubMed ID: 2563251
Title: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.
PubMed ID: 2563251
DOI: 10.1007/bf00293896
PubMed ID: 2463251
Title: Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
PubMed ID: 2463251
PubMed ID: 10322772
Title: Establishment of transgenic cell line CHL-3A4 and its metabolic activation.
PubMed ID: 10322772
PubMed ID: 11266076
Title: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
PubMed ID: 11266076
PubMed ID: 11181494
Title: Novel mutations of CYP3A4 in Chinese.
PubMed ID: 11181494
PubMed ID: 3243766
Title: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.
PubMed ID: 3243766
PubMed ID: 3898085
Title: Identification of an inducible form of cytochrome P-450 in human liver.
PubMed ID: 3898085
PubMed ID: 2732228
Title: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
PubMed ID: 2732228
PubMed ID: 8035341
Title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
PubMed ID: 8035341
PubMed ID: 7894497
Title: CYP3A gene expression in human gut epithelium.
PubMed ID: 7894497
PubMed ID: 8968357
Title: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
PubMed ID: 8968357
PubMed ID: 9435160
Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.
PubMed ID: 9435160
PubMed ID: 10759686
Title: Relative contribution of cytochromes P-450 and flavin-containing monooxygenases to the metabolism of albendazole by human liver microsomes.
PubMed ID: 10759686
PubMed ID: 10681376
Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.
PubMed ID: 10681376
PubMed ID: 11093772
Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
PubMed ID: 11093772
PubMed ID: 11159812
Title: Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
PubMed ID: 11159812
PubMed ID: 11555828
Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
PubMed ID: 11555828
PubMed ID: 11695850
Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
PubMed ID: 11695850
PubMed ID: 11726664
Title: Intergenic mRNA molecules resulting from trans-splicing.
PubMed ID: 11726664
PubMed ID: 14559847
Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.
PubMed ID: 14559847
PubMed ID: 12865317
Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
PubMed ID: 12865317
DOI: 10.1210/en.2003-0192
PubMed ID: 15373842
Title: Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.
PubMed ID: 15373842
PubMed ID: 15764715
Title: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.
PubMed ID: 15764715
PubMed ID: 19094056
Title: ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
PubMed ID: 19094056
PubMed ID: 18545703
Title: Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.
PubMed ID: 18545703
PubMed ID: 19103148
Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.
PubMed ID: 19103148
PubMed ID: 19359404
Title: Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.
PubMed ID: 19359404
PubMed ID: 20702771
Title: Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide.
PubMed ID: 20702771
PubMed ID: 19965576
Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.
PubMed ID: 19965576
DOI: 10.1194/jlr.m003061
PubMed ID: 21490593
Title: Evaluation of 6beta-hydroxycortisol, 6beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.
PubMed ID: 21490593
DOI: 10.1038/clpt.2011.53
PubMed ID: 21576599
PubMed ID: 22773874
Title: Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
PubMed ID: 22773874
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26988023
Title: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
PubMed ID: 26988023
DOI: 10.1038/ncomms11030
PubMed ID: 15258162
Title: The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.
PubMed ID: 15258162
PubMed ID: 15256616
Title: Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.
PubMed ID: 15256616
PubMed ID: 10668853
Title: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.
PubMed ID: 10668853
PubMed ID: 11714865
Title: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.
PubMed ID: 11714865
PubMed ID: 11470997
Title: Identification and functional characterization of eight CYP3A4 protein variants.
PubMed ID: 11470997
PubMed ID: 11875366
Title: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.
PubMed ID: 11875366
PubMed ID: 15469410
Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
PubMed ID: 15469410
PubMed ID: 29461981
Title: CYP3A4 mutation causes vitamin D-dependent rickets type 3.
PubMed ID: 29461981
DOI: 10.1172/jci98680
Sequence Information:
- Length: 503
- Mass: 57343
- Checksum: 38ED122BF89F74F7
- Sequence:
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV SGA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.