Gene CYP3A4 - ENSG00000160868 | NCBI Gene ID: 1576

Details for: CYP3A4

Gene ID: 1576

Symbol: CYP3A4

Ensembl ID: ENSG00000160868

Description: cytochrome P450 family 3 subfamily A member 4

Associated with

Aflatoxin activation and detoxification
(R-HSA-5423646)
Aspirin adme
(R-HSA-9749641)
Atorvastatin adme
(R-HSA-9754706)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Prednisone adme
(R-HSA-9757110)
Xenobiotics
(R-HSA-211981)
1,8-cineole 2-exo-monooxygenase activity
(GO:0102320)
1-alpha,25-dihydroxyvitamin d3 23-hydroxylase activity
(GO:0062181)
Aflatoxin metabolic process
(GO:0046222)
Alkaloid catabolic process
(GO:0009822)
Anandamide 8,9 epoxidase activity
(GO:0062187)
Anandamide 11,12 epoxidase activity
(GO:0062188)
Anandamide 14,15 epoxidase activity
(GO:0062189)
Androgen metabolic process
(GO:0008209)
Aromatase activity
(GO:0070330)
Caffeine oxidase activity
(GO:0034875)
Calcitriol biosynthetic process from calciol
(GO:0036378)
Cholesterol metabolic process
(GO:0008203)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Lipid metabolic process
(GO:0006629)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxygen binding
(GO:0019825)
Protein binding
(GO:0005515)
Quinine 3-monooxygenase activity
(GO:0050591)
Retinoic acid 4-hydroxylase activity
(GO:0008401)
Retinoic acid metabolic process
(GO:0042573)
Retinol metabolic process
(GO:0042572)
Steroid binding
(GO:0005496)
Steroid catabolic process
(GO:0006706)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Testosterone 6-beta-hydroxylase activity
(GO:0050649)
Vitamin d3 25-hydroxylase activity
(GO:0030343)
Vitamin d 24-hydroxylase activity
(GO:0070576)
Vitamin d catabolic process
(GO:0042369)
Vitamin d metabolic process
(GO:0042359)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retina horizontal cell (CL0000745)
Fold Change: 4.46
Marker Score: 4277
Cell Name: amacrine cell (CL0000561)
Fold Change: 3.83
Marker Score: 12284
Cell Name: megakaryocyte (CL0000556)
Fold Change: 2.91
Marker Score: 1651
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 2.6
Marker Score: 7594
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.52
Marker Score: 1326
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.48
Marker Score: 3815
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.43
Marker Score: 3035.5
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.97
Marker Score: 10617
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.94
Marker Score: 12444
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.86
Marker Score: 776
Cell Name: retinal cone cell (CL0000573)
Fold Change: 1.79
Marker Score: 5140
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.65
Marker Score: 478
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.55
Marker Score: 1661
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.44
Marker Score: 6204
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.4
Marker Score: 11851
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.39
Marker Score: 3965
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.35
Marker Score: 2794.5
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.02
Marker Score: 383
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.01
Marker Score: 2990.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1
Marker Score: 674
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: enterocyte (CL0000584)
Fold Change: 0.96
Marker Score: 4622
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.94
Marker Score: 293
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.82
Marker Score: 226
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 319
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.78
Marker Score: 779
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3095.5
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: precursor cell (CL0011115)
Fold Change: 0.67
Marker Score: 163
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.65
Marker Score: 644
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.62
Marker Score: 413
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 455
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.55
Marker Score: 553
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.49
Marker Score: 924
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.47
Marker Score: 263
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.44
Marker Score: 108
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.42
Marker Score: 6535
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.41
Marker Score: 1534
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.39
Marker Score: 640
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.38
Marker Score: 318
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.36
Marker Score: 94
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.35
Marker Score: 702
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.34
Marker Score: 206
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.33
Marker Score: 788
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.33
Marker Score: 226
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.33
Marker Score: 123
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.31
Marker Score: 298
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.31
Marker Score: 116
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.29
Marker Score: 470
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.28
Marker Score: 88
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.27
Marker Score: 112
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.27
Marker Score: 568
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.25
Marker Score: 69
Cell Name: mast cell (CL0000097)
Fold Change: 0.24
Marker Score: 137
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.23
Marker Score: 136
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: paneth cell (CL0000510)
Fold Change: 0.22
Marker Score: 152
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2
Marker Score: 94
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.2
Marker Score: 61
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.2
Marker Score: 81
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 112
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.19
Marker Score: 41
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.17
Marker Score: 62
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.16
Marker Score: 54
Cell Name: pericyte (CL0000669)
Fold Change: 0.16
Marker Score: 93
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.16
Marker Score: 74
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.15
Marker Score: 110
Cell Name: melanocyte (CL0000148)
Fold Change: 0.14
Marker Score: 57
Cell Name: goblet cell (CL0000160)
Fold Change: 0.14
Marker Score: 933
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 62
Cell Name: stem cell (CL0000034)
Fold Change: 0.13
Marker Score: 312
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.12
Marker Score: 93
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.12
Marker Score: 185
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.11
Marker Score: 33
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.11
Marker Score: 1514
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.11
Marker Score: 248
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.11
Marker Score: 82
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1
Marker Score: 596
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1
Marker Score: 134
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.1
Marker Score: 86
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.09
Marker Score: 30
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.09
Marker Score: 23
Cell Name: astrocyte (CL0000127)
Fold Change: 0.09
Marker Score: 76.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.09
Marker Score: 364.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.08
Marker Score: 71
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.08
Marker Score: 783
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.08
Marker Score: 26
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.08
Marker Score: 48

Hover over a box to see details here...

**Key characteristics:** - CYP3A4 is a member of the cytochrome P450 family 3 subfamily A. - It is expressed in a variety of cells, including retina horizontal cells, amacrine cells, megakaryocytes, ON-bipolar cells, hematopoietic stem cells, enterocytes of the colon, retinal ganglion cells, periportal region hepatocyte, centrilobular region hepatocyte, and megakaryocyte-erythroid progenitor cells. - CYP3A4 is a highly expressed enzyme in the retina, where it is involved in the detoxification of aflatoxins. - It is also expressed in high levels in the liver, where it is involved in the metabolism of drugs and toxins. **Pathways and functions:** - CYP3A4 is involved in a variety of metabolic pathways, including the detoxification of aflatoxins, the metabolism of drugs, and the biosynthesis of proresolving mediators. - Aflatoxins are a group of naturally occurring toxins that are produced by certain molds. They can cause liver damage and cancer. - CYP3A4 is responsible for the detoxification of aflatoxins by catalyzing the oxidation of aflatoxin B7 to aflatoxin G1. - It also catalyzes the metabolism of other drugs, such as atorvastatin and prednisone. - CYP3A4 is involved in the biosynthesis of proresolving mediators, which are molecules that promote inflammation and tissue repair. **Clinical significance:** - CYP3A4 gene polymorphisms have been linked to an increased risk of liver cancer. - Mutations in the CYP3A4 gene can lead to the accumulation of aflatoxins in the body, which can damage liver cells and contribute to the development of liver cancer. - CYP3A4 inhibitors are being investigated as a treatment for liver cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

1,8-cineole 2-exo-monooxygenase

Genular Protein ID: 3663061466

Symbol: CP3A4_HUMAN

Name: 1,8-cineole 2-exo-monooxygenase

UniProtKB Accession Codes:

P08684 P05184 Q16757 Q9UK50

Database IDs:

Citations:

PubMed ID: 3460094

Title: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

PubMed ID: 3460094

DOI: 10.1073/pnas.83.14.5311

PubMed ID: 3267210

Title: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.

PubMed ID: 3267210

DOI: 10.1089/dna.1988.7.79

PubMed ID: 3464943

Title: Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

PubMed ID: 3464943

DOI: 10.1073/pnas.83.21.8064

PubMed ID: 2563251

Title: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.

PubMed ID: 2563251

DOI: 10.1007/bf00293896

PubMed ID: 2463251

Title: Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.

PubMed ID: 2463251

DOI: 10.1016/s0021-9258(19)85029-9

PubMed ID: 10322772

Title: Establishment of transgenic cell line CHL-3A4 and its metabolic activation.

PubMed ID: 10322772

PubMed ID: 11266076

Title: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

PubMed ID: 11266076

DOI: 10.1097/00008571-200103000-00002

PubMed ID: 11181494

Title: Novel mutations of CYP3A4 in Chinese.

PubMed ID: 11181494

PubMed ID: 3243766

Title: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.

PubMed ID: 3243766

DOI: 10.1093/oxfordjournals.jbchem.a122582

PubMed ID: 3898085

Title: Identification of an inducible form of cytochrome P-450 in human liver.

PubMed ID: 3898085

DOI: 10.1073/pnas.82.18.6310

PubMed ID: 2732228

Title: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

PubMed ID: 2732228

DOI: 10.1016/s0021-9258(18)81632-5

PubMed ID: 8035341

Title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

PubMed ID: 8035341

PubMed ID: 7894497

Title: CYP3A gene expression in human gut epithelium.

PubMed ID: 7894497

DOI: 10.1097/00008571-199410000-00003

PubMed ID: 8968357

Title: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.

PubMed ID: 8968357

PubMed ID: 9435160

Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

PubMed ID: 9435160

PubMed ID: 10759686

Title: Relative contribution of cytochromes P-450 and flavin-containing monooxygenases to the metabolism of albendazole by human liver microsomes.

PubMed ID: 10759686

DOI: 10.1046/j.1365-2125.2000.00170.x

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 11159812

Title: Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.

PubMed ID: 11159812

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 11726664

Title: Intergenic mRNA molecules resulting from trans-splicing.

PubMed ID: 11726664

DOI: 10.1074/jbc.m109175200

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15373842

Title: Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.

PubMed ID: 15373842

DOI: 10.1111/j.1432-1033.2004.04339.x

PubMed ID: 15764715

Title: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.

PubMed ID: 15764715

DOI: 10.1124/dmd.104.003327

PubMed ID: 19094056

Title: ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

PubMed ID: 19094056

DOI: 10.1111/j.1471-4159.2008.05720.x

PubMed ID: 18545703

Title: Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.

PubMed ID: 18545703

DOI: 10.1371/journal.pone.0002337

PubMed ID: 19103148

Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

PubMed ID: 19103148

DOI: 10.1016/j.abb.2008.12.001

PubMed ID: 19359404

Title: Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

PubMed ID: 19359404

DOI: 10.1124/dmd.109.027011

PubMed ID: 20702771

Title: Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide.

PubMed ID: 20702771

DOI: 10.1124/dmd.110.033712

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 21490593

Title: Evaluation of 6beta-hydroxycortisol, 6beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.

PubMed ID: 21490593

DOI: 10.1038/clpt.2011.53

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 22773874

Title: Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.

PubMed ID: 22773874

DOI: 10.1074/jbc.m112.390047

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26988023

Title: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

PubMed ID: 26988023

DOI: 10.1038/ncomms11030

PubMed ID: 15258162

Title: The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.

PubMed ID: 15258162

DOI: 10.1074/jbc.c400293200

PubMed ID: 15256616

Title: Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

PubMed ID: 15256616

DOI: 10.1126/science.1099736

PubMed ID: 10668853

Title: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

PubMed ID: 10668853

DOI: 10.1067/mcp.2000.104391

PubMed ID: 11714865

Title: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

PubMed ID: 11714865

PubMed ID: 11470997

Title: Identification and functional characterization of eight CYP3A4 protein variants.

PubMed ID: 11470997

DOI: 10.1097/00008571-200107000-00008

PubMed ID: 11875366

Title: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.

PubMed ID: 11875366

DOI: 10.1097/00008571-200203000-00006

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 29461981

Title: CYP3A4 mutation causes vitamin D-dependent rickets type 3.

PubMed ID: 29461981

DOI: 10.1172/jci98680

Sequence Information:

Length: 503
Mass: 57343
Checksum: 38ED122BF89F74F7
Sequence:

MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF 
DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI 
AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS 
MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV 
FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI 
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV 
NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS 
KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG 
GLLQPEKPVV LKVESRDGTV SGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CYP3A4

Associated with

Cells (max top 100)

Other Information

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. PubMed ID: 3460094

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. PubMed ID: 3267210

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. PubMed ID: 3464943

The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter. PubMed ID: 2563251

Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. PubMed ID: 2463251

Establishment of transgenic cell line CHL-3A4 and its metabolic activation. PubMed ID: 10322772

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. PubMed ID: 11266076

Novel mutations of CYP3A4 in Chinese. PubMed ID: 11181494

Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization. PubMed ID: 3243766

Identification of an inducible form of cytochrome P-450 in human liver. PubMed ID: 3898085

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. PubMed ID: 2732228

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. PubMed ID: 8035341

CYP3A gene expression in human gut epithelium. PubMed ID: 7894497

Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. PubMed ID: 8968357

Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. PubMed ID: 9435160

Relative contribution of cytochromes P-450 and flavin-containing monooxygenases to the metabolism of albendazole by human liver microsomes. PubMed ID: 10759686

Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. PubMed ID: 10681376

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. PubMed ID: 11093772

Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. PubMed ID: 11159812

Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. PubMed ID: 11555828

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. PubMed ID: 11695850

Intergenic mRNA molecules resulting from trans-splicing. PubMed ID: 11726664

Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. PubMed ID: 14559847

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4. PubMed ID: 15373842

Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. PubMed ID: 15764715

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. PubMed ID: 19094056

Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PubMed ID: 18545703

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. PubMed ID: 19103148

Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. PubMed ID: 19359404

Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide. PubMed ID: 20702771

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576

Evaluation of 6beta-hydroxycortisol, 6beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo. PubMed ID: 21490593

Cholesterol 25-hydroxylation activity of CYP3A. PubMed ID: 21576599

Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. PubMed ID: 22773874

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. PubMed ID: 26988023

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. PubMed ID: 15258162

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. PubMed ID: 15256616

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. PubMed ID: 10668853

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. PubMed ID: 11714865

Identification and functional characterization of eight CYP3A4 protein variants. PubMed ID: 11470997

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. PubMed ID: 11875366

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

CYP3A4 mutation causes vitamin D-dependent rickets type 3. PubMed ID: 29461981