CYP3A5 | ENSG00000106258 | NCBI 1577

Details for: CYP3A5

Gene ID: 1577

Symbol: CYP3A5

Ensembl ID: ENSG00000106258

Description: cytochrome P450 family 3 subfamily A member 5

Associated with

Aflatoxin activation and detoxification
(R-HSA-5423646)
Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Aflatoxin metabolic process
(GO:0046222)
Alkaloid catabolic process
(GO:0009822)
Aromatase activity
(GO:0070330)
Endoplasmic reticulum membrane
(GO:0005789)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Monooxygenase activity
(GO:0004497)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxygen binding
(GO:0019825)
Protein binding
(GO:0005515)
Retinoic acid 4-hydroxylase activity
(GO:0008401)
Retinoic acid metabolic process
(GO:0042573)
Retinol metabolic process
(GO:0042572)
Steroid metabolic process
(GO:0008202)
Testosterone 6-beta-hydroxylase activity
(GO:0050649)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 3
Marker Score: 16,136
Cell Name: enterocyte (CL0000584)
Fold Change: 2.82
Marker Score: 13,545
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.69
Marker Score: 17,182
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.57
Marker Score: 3,960
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.57
Marker Score: 2,021
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.32
Marker Score: 7,284
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.3
Marker Score: 3,327
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.29
Marker Score: 839
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.24
Marker Score: 1,796
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.23
Marker Score: 3,291
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.19
Marker Score: 543
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.11
Marker Score: 13,564
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.08
Marker Score: 1,210
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2
Marker Score: 8,644
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.98
Marker Score: 571
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.82
Marker Score: 6,446
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.75
Marker Score: 1,744
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.57
Marker Score: 453
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.56
Marker Score: 5,111
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.54
Marker Score: 3,504
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.54
Marker Score: 1,645
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.48
Marker Score: 1,421
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169,036
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.39
Marker Score: 524
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 1.39
Marker Score: 781
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.26
Marker Score: 456
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.25
Marker Score: 3,064
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.23
Marker Score: 1,279
Cell Name: precursor cell (CL0011115)
Fold Change: 1.2
Marker Score: 292
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.13
Marker Score: 774
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.12
Marker Score: 423
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.04
Marker Score: 8,083
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,794
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,019
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404
Cell Name: stem cell (CL0000034)
Fold Change: 0.97
Marker Score: 2,314
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.97
Marker Score: 196
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.95
Marker Score: 8,191
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.94
Marker Score: 249
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,325
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1,507
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.92
Marker Score: 13,772
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.9
Marker Score: 280
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.89
Marker Score: 434
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.84
Marker Score: 953
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.79
Marker Score: 778
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.77
Marker Score: 535
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.76
Marker Score: 678
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.76
Marker Score: 198
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.74
Marker Score: 742
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.73
Marker Score: 305
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.71
Marker Score: 205
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 638
Cell Name: paneth cell (CL0000510)
Fold Change: 0.69
Marker Score: 480
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,858
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.66
Marker Score: 227
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.66
Marker Score: 181
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.66
Marker Score: 2,330
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.65
Marker Score: 259
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.64
Marker Score: 14,346
Cell Name: secretory cell (CL0000151)
Fold Change: 0.62
Marker Score: 1,133
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.61
Marker Score: 1,508
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.6
Marker Score: 499
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.58
Marker Score: 953
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.58
Marker Score: 217
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.57
Marker Score: 1,429
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.56
Marker Score: 245
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.56
Marker Score: 1,184
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.55
Marker Score: 584
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.55
Marker Score: 151
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.55
Marker Score: 205
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 434
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.54
Marker Score: 837
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.54
Marker Score: 300
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.53
Marker Score: 472
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.53
Marker Score: 266
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.5
Marker Score: 261
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.5
Marker Score: 170
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.49
Marker Score: 156
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.48
Marker Score: 153
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.47
Marker Score: 272
Cell Name: fat cell (CL0000136)
Fold Change: 0.46
Marker Score: 256
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.45
Marker Score: 130
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.44
Marker Score: 204
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.44
Marker Score: 228
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.44
Marker Score: 106
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.43
Marker Score: 118
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.43
Marker Score: 423
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.41
Marker Score: 894
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.38
Marker Score: 477

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** CYP3A5 is a non-steroidal member of the cytochrome P450 superfamily, characterized by its ability to catalyze monooxygenase reactions. The gene is highly conserved across species, with a high degree of sequence similarity to other cytochrome P450 enzymes. The CYP3A5 enzyme is a heme-containing protein, which is essential for its catalytic activity. The gene is transcribed in the nucleus and translated into a polypeptide chain, which is then inserted into the endoplasmic reticulum membrane. **Pathways and Functions:** The CYP3A5 enzyme is involved in the metabolism of a wide range of substances, including: 1. **Xenobiotics:** CYP3A5 plays a critical role in the detoxification of xenobiotics, such as drugs, pesticides, and environmental pollutants. 2. **Steroids:** The enzyme is involved in the metabolism of steroids, including testosterone and estrogen, which are essential for various physiological processes. 3. **Endogenous compounds:** CYP3A5 also metabolizes endogenous compounds, such as retinoids and retinoic acid, which are involved in cell growth and differentiation. 4. **Aflatoxin activation:** The enzyme is involved in the activation of aflatoxins, which are potent carcinogens produced by certain fungi. The CYP3A5 enzyme is also involved in various cellular processes, including: 1. **Heme binding:** The enzyme binds heme, which is essential for its catalytic activity. 2. **Oxidative demethylation:** CYP3A5 is involved in the oxidative demethylation of various compounds, which is a critical step in their metabolism. 3. **Lipid hydroxylation:** The enzyme is involved in the lipid hydroxylation of various compounds, which is essential for their metabolism and detoxification. **Clinical Significance:** The CYP3A5 enzyme plays a critical role in various clinical processes, including: 1. **Drug metabolism:** The enzyme is involved in the metabolism of many drugs, including immunosuppressants, antibiotics, and anticonvulsants. 2. **Cancer treatment:** CYP3A5 is involved in the metabolism of certain cancer therapies, including docetaxel and paclitaxel. 3. **Allergic reactions:** The enzyme is involved in the metabolism of allergens, which can lead to allergic reactions. 4. **Infectious diseases:** CYP3A5 is involved in the metabolism of certain antibiotics, which can lead to treatment failure. In conclusion, the CYP3A5 gene is a crucial component of the cytochrome P450 superfamily, playing a vital role in the metabolism and detoxification of various substances. Its expression in various tissues and its involvement in multiple physiological processes underscore its importance in human health and disease. Further research into the CYP3A5 enzyme is necessary to fully understand its role in human disease and to develop novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CYPIIIA5
B7Z3P6_HUMAN

Genular Protein ID: 2684542022

Symbol: CP3A5_HUMAN

Name: CYPIIIA5

UniProtKB Accession Codes:

P20815 A4D289 B7Z5I7 Q53WY8 Q75MV0 Q9HB56

Database IDs:

Citations:

PubMed ID: 2732228

Title: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

PubMed ID: 2732228

DOI: 10.1016/s0021-9258(18)81632-5

PubMed ID: 2802615

Title: Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.

PubMed ID: 2802615

DOI: 10.1016/0003-9861(89)90449-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11266076

Title: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

PubMed ID: 11266076

DOI: 10.1097/00008571-200103000-00002

PubMed ID: 8569713

Title: Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.

PubMed ID: 8569713

PubMed ID: 7811260

Title: Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

PubMed ID: 7811260

DOI: 10.1006/bbrc.1994.2870

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11093772

Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

PubMed ID: 11093772

DOI: 10.1124/mol.58.6.1341

PubMed ID: 11726664

Title: Intergenic mRNA molecules resulting from trans-splicing.

PubMed ID: 11726664

DOI: 10.1074/jbc.m109175200

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8619878

Title: Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

PubMed ID: 8619878

DOI: 10.1006/bbrc.1996.0618

PubMed ID: 11502729

Title: Genetic polymorphism of cytochrome P450 3A5 in Chinese.

PubMed ID: 11502729

PubMed ID: 12893984

Title: Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.

PubMed ID: 12893984

DOI: 10.1097/00008571-200308000-00004

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

Sequence Information:

Length: 502
Mass: 57109
Checksum: D5A2302E2633E717
Sequence:

MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF 
DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL 
AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS 
MDVITGTSFG VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL 
FPKDTINFLS KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI 
IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV 
NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS 
KKKDSIDPYI YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG 
LLQPEKPIVL KVDSRDGTLS GE

Genular Protein ID: 369579349

Symbol: B7Z3P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3P6

Database IDs:

Sequence Information:

Length: 492
Mass: 56070
Checksum: 6EBD4EC8756815C9
Sequence:

MQLLMLELLL LFIVYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK 
MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR 
SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG 
VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS 
KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI IFIFAGYETT 
SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV NETLRLFPVA 
IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS KKKDSIDPYV 
YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL 
KVDSRDGTLS GE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP3A5

Associated with

Cells (max top 100)

Other Information

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. PubMed ID: 2732228

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. PubMed ID: 2802615

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. PubMed ID: 11266076

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. PubMed ID: 8569713

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. PubMed ID: 7811260

Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. PubMed ID: 10681376

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. PubMed ID: 11093772

Intergenic mRNA molecules resulting from trans-splicing. PubMed ID: 11726664

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein? PubMed ID: 8619878

Genetic polymorphism of cytochrome P450 3A5 in Chinese. PubMed ID: 11502729

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. PubMed ID: 12893984

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410