Details for: CYP3A5
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 3
Marker Score: 16,136 - Cell Name: enterocyte (CL0000584)
Fold Change: 2.82
Marker Score: 13,545 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.69
Marker Score: 17,182 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.57
Marker Score: 3,960 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.57
Marker Score: 2,021 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.32
Marker Score: 7,284 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.3
Marker Score: 3,327 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.29
Marker Score: 839 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.24
Marker Score: 1,796 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.23
Marker Score: 3,291 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.19
Marker Score: 543 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.11
Marker Score: 13,564 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.08
Marker Score: 1,210 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2
Marker Score: 8,644 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.98
Marker Score: 571 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.82
Marker Score: 6,446 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.75
Marker Score: 1,744 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.57
Marker Score: 453 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.56
Marker Score: 5,111 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.54
Marker Score: 3,504 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.54
Marker Score: 1,645 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.48
Marker Score: 1,421 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169,036 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.39
Marker Score: 524 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 1.39
Marker Score: 781 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.26
Marker Score: 456 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.25
Marker Score: 3,064 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.23
Marker Score: 1,279 - Cell Name: precursor cell (CL0011115)
Fold Change: 1.2
Marker Score: 292 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.13
Marker Score: 774 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.12
Marker Score: 423 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.04
Marker Score: 8,083 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,794 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,019 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404 - Cell Name: stem cell (CL0000034)
Fold Change: 0.97
Marker Score: 2,314 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.97
Marker Score: 196 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.95
Marker Score: 8,191 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.94
Marker Score: 249 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,325 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1,507 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.92
Marker Score: 13,772 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.9
Marker Score: 280 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.89
Marker Score: 434 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.84
Marker Score: 953 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.79
Marker Score: 778 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.77
Marker Score: 535 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.76
Marker Score: 678 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.76
Marker Score: 198 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.74
Marker Score: 742 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.73
Marker Score: 305 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.71
Marker Score: 205 - Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 638 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.69
Marker Score: 480 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,858 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.66
Marker Score: 227 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.66
Marker Score: 181 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.66
Marker Score: 2,330 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.65
Marker Score: 259 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.64
Marker Score: 14,346 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.62
Marker Score: 1,133 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.61
Marker Score: 1,508 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.6
Marker Score: 499 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.58
Marker Score: 953 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.58
Marker Score: 217 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.57
Marker Score: 1,429 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.56
Marker Score: 245 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.56
Marker Score: 1,184 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.55
Marker Score: 584 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.55
Marker Score: 151 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.55
Marker Score: 205 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 434 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.54
Marker Score: 837 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.54
Marker Score: 300 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.53
Marker Score: 472 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.53
Marker Score: 266 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.5
Marker Score: 261 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.5
Marker Score: 170 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.49
Marker Score: 156 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.48
Marker Score: 153 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.47
Marker Score: 272 - Cell Name: fat cell (CL0000136)
Fold Change: 0.46
Marker Score: 256 - Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.45
Marker Score: 130 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.44
Marker Score: 204 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.44
Marker Score: 228 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.44
Marker Score: 106 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.43
Marker Score: 118 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.43
Marker Score: 423 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.41
Marker Score: 894 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.38
Marker Score: 477
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2684542022
Symbol: CP3A5_HUMAN
Name: CYPIIIA5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2732228
Title: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
PubMed ID: 2732228
PubMed ID: 2802615
Title: Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.
PubMed ID: 2802615
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11266076
Title: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
PubMed ID: 11266076
PubMed ID: 8569713
Title: Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
PubMed ID: 8569713
PubMed ID: 7811260
Title: Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.
PubMed ID: 7811260
PubMed ID: 10681376
Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.
PubMed ID: 10681376
PubMed ID: 11093772
Title: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
PubMed ID: 11093772
PubMed ID: 11726664
Title: Intergenic mRNA molecules resulting from trans-splicing.
PubMed ID: 11726664
PubMed ID: 12865317
Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
PubMed ID: 12865317
DOI: 10.1210/en.2003-0192
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 8619878
Title: Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?
PubMed ID: 8619878
PubMed ID: 11502729
Title: Genetic polymorphism of cytochrome P450 3A5 in Chinese.
PubMed ID: 11502729
PubMed ID: 12893984
Title: Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.
PubMed ID: 12893984
PubMed ID: 15469410
Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
PubMed ID: 15469410
Sequence Information:
- Length: 502
- Mass: 57109
- Checksum: D5A2302E2633E717
- Sequence:
MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS KKKDSIDPYI YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSRDGTLS GE
Genular Protein ID: 369579349
Symbol: B7Z3P6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 492
- Mass: 56070
- Checksum: 6EBD4EC8756815C9
- Sequence:
MQLLMLELLL LFIVYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS KKKDSIDPYV YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSRDGTLS GE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.