Details for: CYP3A51P

Gene ID: 1578

Symbol: CYP3A51P

Ensembl ID: ENSG00000282277

Description: cytochrome P450 family 3 subfamily A member 51, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0967
    Cell Significance Index: 1.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0649
    Cell Significance Index: 0.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0121
    Cell Significance Index: 0.1400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0101
    Cell Significance Index: -0.5200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1103
    Cell Significance Index: -1.3400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1106
    Cell Significance Index: -1.3900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1130
    Cell Significance Index: -1.0000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1228
    Cell Significance Index: -1.5400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1237
    Cell Significance Index: -1.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1398
    Cell Significance Index: -1.6500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1407
    Cell Significance Index: -1.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1459
    Cell Significance Index: -1.9400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1469
    Cell Significance Index: -1.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1596
    Cell Significance Index: -1.3200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1616
    Cell Significance Index: -1.7400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1692
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: CYP3A51P is a pseudogene, meaning it lacks a functional coding sequence and is unable to produce a protein. 2. **Widespread expression**: This gene is significantly expressed in various retinal cell types, including retinal rod cells, ganglion cells, amacrine cells, and horizontal cells. 3. **Evolutionary conservation**: The CYP3A51P gene has been conserved across species, suggesting its importance in retinal function. **Pathways and Functions:** Despite its pseudogene status, CYP3A51P has been implicated in various cellular processes, including: 1. **Retinal development**: The expression of CYP3A51P in retinal progenitor cells suggests its involvement in retinal development and differentiation. 2. **Cellular signaling**: CYP3A51P may play a role in cellular signaling pathways, such as the regulation of calcium homeostasis in retinal cells. 3. **Antioxidant defense**: The expression of CYP3A51P in retinal cells may contribute to antioxidant defense mechanisms, protecting against oxidative stress and damage. **Clinical Significance:** The clinical significance of CYP3A51P is an area of ongoing research. However, its expression in retinal cells raises several questions: 1. **Retinal disease association**: CYP3A51P may be associated with retinal diseases, such as retinitis pigmentosa or age-related macular degeneration. 2. **Gene therapy applications**: The pseudogene status of CYP3A51P may make it an attractive target for gene therapy, allowing for the delivery of functional genes to retinal cells. 3. **Cancer association**: The expression of CYP3A51P in retinal cells has been linked to cancer, suggesting its potential role in tumorigenesis. In conclusion, the CYP3A51P gene, despite its pseudogene status, has been identified as a significant player in retinal cell biology. Further research is needed to fully understand its role in retinal function and disease, as well as its potential applications in gene therapy and cancer research.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.