Details for: CYP4A11

Gene ID: 1579

Symbol: CYP4A11

Ensembl ID: ENSG00000187048

Description: cytochrome P450 family 4 subfamily A member 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.22
    Marker Score: 10536
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.44
    Marker Score: 2584
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.61
    Marker Score: 1602
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.6
    Marker Score: 1095
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.55
    Marker Score: 8349
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.48
    Marker Score: 6375
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.34
    Marker Score: 8601
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2496
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.17
    Marker Score: 2754
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.12
    Marker Score: 3994
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1
    Marker Score: 6662
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3109
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.66
    Marker Score: 703
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1258
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.43
    Marker Score: 134
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6664
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.41
    Marker Score: 155
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.38
    Marker Score: 211
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 228
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 230
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 160
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.26
    Marker Score: 424
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.25
    Marker Score: 69
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 78
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 173
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 113
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 130
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 164
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 228
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 729
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.11
    Marker Score: 187
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.11
    Marker Score: 173
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 79
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.1
    Marker Score: 98
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1
    Marker Score: 201
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 82
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.09
    Marker Score: 169.5
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.09
    Marker Score: 121
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 166.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.08
    Marker Score: 193
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.07
    Marker Score: 216
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 281
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 179

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Other Information

**Key characteristics:** - The CYP4A11 gene is located on chromosome 15q21.1. - It is a large gene, encoding a protein of 1,417 amino acids. - The protein is a monooxygenase that catalyzes the oxidation of various substrates. **Pathways and functions:** - CYP4A11 enzymes are involved in multiple pathways, including: - Alkane 1-monooxygenase activity - Arachidonic acid epoxygenase activity - Arachidonic acid metabolism - Arachidonic acid monooxygenase activity - Biological oxidations - Cytochrome p450 - arranged by substrate type - Eicosanoids - Fatty acid metabolism - Fatty acids - Iron ion binding - Metabolism - Metabolism of lipids - Miscellaneous substrates - These pathways are involved in a variety of biological processes, including: - Detoxification - Cholesterol metabolism - Steroid metabolism - Inflammation - Cardiovascular health **Clinical significance:** - Mutations in the CYP4A11 gene have been linked to several human diseases, including: - Hyperlipidemia - Hypertension - Diabetes - Coronary artery disease - Cancer - Inhibition of CYP4A11 enzymes has been shown to improve lipid profiles and reduce inflammation in animal models of disease. - Therefore, CYP4A11 is a potential therapeutic target for the treatment of these diseases.

Genular Protein ID: 2408426515

Symbol: CP4AB_HUMAN

Name: CYP4AII

UniProtKB Accession Codes:

Q02928 Q06766 Q16865 Q16866 Q5VSP8 Q86SU6 Q8IWY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 81 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 EC 4 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 Rhea 44 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7679927

Title: Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.

PubMed ID: 7679927

DOI: 10.1016/0167-4781(93)90285-l

PubMed ID: 7798189

Title: Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase.

PubMed ID: 7798189

DOI: 10.1093/oxfordjournals.jbchem.a124506

PubMed ID: 8274222

Title: Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.

PubMed ID: 8274222

DOI: 10.1089/dna.1993.12.893

PubMed ID: 12464262

Title: Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

PubMed ID: 12464262

DOI: 10.1016/s0003-9861(02)00545-3

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1739747

Title: Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases.

PubMed ID: 1739747

DOI: 10.1016/0005-2760(92)90106-6

PubMed ID: 8363569

Title: Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

PubMed ID: 8363569

DOI: 10.1042/bj2940173

PubMed ID: 8914854

Title: Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes.

PubMed ID: 8914854

DOI: 10.1006/abbi.1996.0501

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 10620324

Title: Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.

PubMed ID: 10620324

DOI: 10.1006/abbi.1999.1504

PubMed ID: 10660572

Title: Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11.

PubMed ID: 10660572

DOI: 10.1074/jbc.275.6.4118

PubMed ID: 11139583

Title: Covalently linked heme in cytochrome P4504A fatty acid hydroxylases.

PubMed ID: 11139583

DOI: 10.1074/jbc.m009969200

PubMed ID: 11821421

Title: Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.

PubMed ID: 11821421

DOI: 10.1074/jbc.m112155200

PubMed ID: 15145985

Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

PubMed ID: 15145985

DOI: 10.1194/jlr.m300463-jlr200

PubMed ID: 15611369

Title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

PubMed ID: 15611369

DOI: 10.1161/01.cir.0000151309.82473.59

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 18065749

Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

PubMed ID: 18065749

DOI: 10.1194/jlr.m700450-jlr200

PubMed ID: 15895287

Title: Highly polymorphic human CYP4A11 gene.

PubMed ID: 15895287

DOI: 10.1007/s10038-005-0245-9

Sequence Information:

  • Length: 519
  • Mass: 59348
  • Checksum: A8D3073EEFF48AE9
  • Sequence:
    • MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ FPCPPSHWLF 
GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY 
RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEELLGQD 
SPLEVFQHVS LMTLDTIMKC AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND 
TIYSLTSAGR WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM 
ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE IHSLLGDGAS 
ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP DGRSLPKGIM VLLSIYGLHH 
NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL 
LPDPTRIPIP IARLVLKSKN GIHLRLRRLP NPCEDKDQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.