Details for: CYP4A11

Gene ID: 1579

Symbol: CYP4A11

Ensembl ID: ENSG00000187048

Description: cytochrome P450 family 4 subfamily A member 11

Associated with

Other Information

Genular Protein ID: 2408426515

Symbol: CP4AB_HUMAN

Name: CYP4AII

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7679927

Title: Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.

PubMed ID: 7679927

DOI: 10.1016/0167-4781(93)90285-l

PubMed ID: 7798189

Title: Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase.

PubMed ID: 7798189

DOI: 10.1093/oxfordjournals.jbchem.a124506

PubMed ID: 8274222

Title: Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.

PubMed ID: 8274222

DOI: 10.1089/dna.1993.12.893

PubMed ID: 12464262

Title: Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

PubMed ID: 12464262

DOI: 10.1016/s0003-9861(02)00545-3

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1739747

Title: Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases.

PubMed ID: 1739747

DOI: 10.1016/0005-2760(92)90106-6

PubMed ID: 8363569

Title: Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

PubMed ID: 8363569

DOI: 10.1042/bj2940173

PubMed ID: 8914854

Title: Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes.

PubMed ID: 8914854

DOI: 10.1006/abbi.1996.0501

PubMed ID: 10553002

Title: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.

PubMed ID: 10553002

PubMed ID: 10620324

Title: Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.

PubMed ID: 10620324

DOI: 10.1006/abbi.1999.1504

PubMed ID: 10660572

Title: Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11.

PubMed ID: 10660572

DOI: 10.1074/jbc.275.6.4118

PubMed ID: 11139583

Title: Covalently linked heme in cytochrome P4504A fatty acid hydroxylases.

PubMed ID: 11139583

DOI: 10.1074/jbc.m009969200

PubMed ID: 11821421

Title: Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.

PubMed ID: 11821421

DOI: 10.1074/jbc.m112155200

PubMed ID: 15145985

Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

PubMed ID: 15145985

DOI: 10.1194/jlr.m300463-jlr200

PubMed ID: 15611369

Title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

PubMed ID: 15611369

DOI: 10.1161/01.cir.0000151309.82473.59

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 18065749

Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

PubMed ID: 18065749

DOI: 10.1194/jlr.m700450-jlr200

PubMed ID: 15895287

Title: Highly polymorphic human CYP4A11 gene.

PubMed ID: 15895287

DOI: 10.1007/s10038-005-0245-9

Sequence Information:

  • Length: 519
  • Mass: 59348
  • Checksum: A8D3073EEFF48AE9
  • Sequence:
  • MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ FPCPPSHWLF 
    GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY 
    RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEELLGQD 
    SPLEVFQHVS LMTLDTIMKC AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND 
    TIYSLTSAGR WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM 
    ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE IHSLLGDGAS 
    ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP DGRSLPKGIM VLLSIYGLHH 
    NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL 
    LPDPTRIPIP IARLVLKSKN GIHLRLRRLP NPCEDKDQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.