Details for: CYP4B1

Gene ID: 1580

Symbol: CYP4B1

Ensembl ID: ENSG00000142973

Description: cytochrome P450 family 4 subfamily B member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 7.27
    Marker Score: 11191
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.36
    Marker Score: 5253
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.61
    Marker Score: 2374
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.24
    Marker Score: 28162
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.87
    Marker Score: 21330
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.81
    Marker Score: 1880
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.81
    Marker Score: 9663
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.37
    Marker Score: 651
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.2
    Marker Score: 4184
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.13
    Marker Score: 3142
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.02
    Marker Score: 583
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.95
    Marker Score: 875
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.73
    Marker Score: 2016
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.65
    Marker Score: 380
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.65
    Marker Score: 26456
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.64
    Marker Score: 766
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.58
    Marker Score: 2890
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.54
    Marker Score: 1212
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.52
    Marker Score: 386
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5
    Marker Score: 6459
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.43
    Marker Score: 9302
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.39
    Marker Score: 343
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.39
    Marker Score: 659
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.25
    Marker Score: 6545
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.24
    Marker Score: 1303
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.23
    Marker Score: 10608.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.22
    Marker Score: 1521
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.18
    Marker Score: 581.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.17
    Marker Score: 9143
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4797
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.1
    Marker Score: 222.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.09
    Marker Score: 963
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.04
    Marker Score: 2539
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.02
    Marker Score: 1324
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1777
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5311
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.87
    Marker Score: 398
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.87
    Marker Score: 485
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.85
    Marker Score: 1346
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.82
    Marker Score: 569
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.72
    Marker Score: 929
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1437
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4234
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 477
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.69
    Marker Score: 1117
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.66
    Marker Score: 415
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10208
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1469
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.62
    Marker Score: 664
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.61
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.51
    Marker Score: 154
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 235
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 152.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.45
    Marker Score: 378
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.45
    Marker Score: 507
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 214.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.43
    Marker Score: 1222
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.42
    Marker Score: 376
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 672
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 403
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.42
    Marker Score: 375
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 81
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.41
    Marker Score: 412
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.41
    Marker Score: 253
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.41
    Marker Score: 100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 352
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.39
    Marker Score: 141
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.38
    Marker Score: 187
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 97

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Other Information

**Key characteristics:** * The CYP4B1 gene is located on chromosome 17q21.1. * It is a large gene with a total length of approximately 11.8 kb. * The protein encoded by CYP4B1 is a transmembrane protein with a molecular weight of approximately 600 kDa. * CYP4B1 is a member of the cytochrome P450 superfamily, which is a large family of enzymes that are involved in a variety of metabolic pathways. **Pathways and functions:** * CYP4B1 is involved in a variety of metabolic pathways, including arachidonic acid metabolism, aromatase activity, biological oxidations, the biphenyl metabolic process, the cytochrome p450 - arranged by substrate type, eicosanoids, endoplasmic reticulum membrane, fatty acid metabolic process, fatty acid metabolism, fatty acids, heme binding, heterocyclic compound binding, iron ion binding, metabolism, and the synthesis of leukotrienes (LTs) and eoxins (exs). **Clinical significance:** * Mutations in the CYP4B1 gene have been linked to a number of human diseases, including liver disease, cardiovascular disease, and cancer. * CYP4B1 inhibitors are being developed as potential treatments for these diseases.

Genular Protein ID: 2258627119

Symbol: CP4B1_HUMAN

Name: Cytochrome P450 4B1

UniProtKB Accession Codes:

P13584 Q1HBI2 Q8TD85 Q8WWF2 Q8WWU9 Q8WWV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2574990

Title: Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping.

PubMed ID: 2574990

DOI: 10.1021/bi00446a014

PubMed ID: 2298205

Title: cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression.

PubMed ID: 2298205

DOI: 10.1111/j.1432-1033.1990.tb15273.x

PubMed ID: 12142726

Title: Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant.

PubMed ID: 12142726

DOI: 10.1097/00008571-200207000-00004

PubMed ID: 12695542

Title: Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole.

PubMed ID: 12695542

DOI: 10.1124/mol.63.5.1137

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 511
  • Mass: 58991
  • Checksum: 91FED40949507EB8
  • Sequence:
    • MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP THWLFGHALE 
IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA KAVYSRGDPK APDVYDFFLQ 
WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL KPYVAVFTES TRIMLDKWEE KAREGKSFDI 
FCDVGHMALN TLMKCTFGRG DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT 
PHGRRFLRAC QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL 
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG DQDFFQWDDL 
GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP AGSLISMHIY ALHRNSAVWP 
DPEVFDSLRF STENASKRHP FAFMPFSAGP RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP 
SRLPIKMPQL VLRSKNGFHL HLKPLGPGSG K

Genular Protein ID: 2547540530

Symbol: Q8IZB0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IZB0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 497
  • Mass: 57242
  • Checksum: 2DC4261F68E102B5
  • Sequence:
    • MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP THWLFGHALE 
IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA KAVYSRGGRG LLVLEGPKWL 
QHRKLLTPGF HYDVLKPYVA VFTESTRIML DKWEEKAREG KSFDIFCDVG HMALNTLMKC 
TFGRGDTGLG HSRDSSYYLA VSDLTLLMQQ RLVSFQYHND FIYWLTPHGR RFLRACQVAH 
DHTDQVIRER KAALQDEKVR KKIQNRRHLD FLDILLGARD EDDIKLSDAD LRAEVDTFMF 
EGHDTTTSGI SWFLYCMALY PEHQHRCREE VREILGDQDF FQWDDLGKMT YLTMCIKESF 
RLYPPVPQVY RQLSKPVTFV DGRSLPAGSL ISMHIYALHR NSAVWPDPEV FDSLRFSTEN 
ASKRHPFAFM PFSAGPRNCI GQQFAMSEMK VVTAMCLLRF EFSLDPSRLP IKMPQLVLRS 
KNGFHLHLKP LGPGSGK

Genular Protein ID: 4010543817

Symbol: B4DV41_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DV41

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 RefSeq 3 SUPFAM 1

Sequence Information:

  • Length: 218
  • Mass: 25767
  • Checksum: B980F7137A05AA53
  • Sequence:
    • MLDKWEEKAR EGKSFDIFCD VGHMALNTLM KCTFGRGDTG LGHRDSSYYL AVSDLTLLMQ 
QRLVSFQYHN DFIYWLTPHG RRFLRACQVA HDHTDQVIRE RKAALQDEKV RKKIQNRRHL 
DFLDILLGAR DEDDIKLSDA DLRAEVDTFM FEGHDTTTSG ISWFLYCMAL YPEHQHRCRE 
EVREILGDQD FFQWDDLGKM TYLTMCIKES FRLYPPVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.