Genular: Defining Cellular Identity and Function

Details for: Iapp

Gene ID: 15874

Symbol: Iapp

Ensembl ID: ENSMUSG00000041681

Description: islet amyloid polypeptide

Associated with

Calcitonin-like ligand receptors
(R-MMU-419812)
Class b/2 (secretin family receptors)
(R-MMU-373080)
G alpha (s) signalling events
(R-MMU-418555)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Amylin receptor signaling pathway
(GO:0097647)
Amyloid fibril formation
(GO:1990000)
Bone resorption
(GO:0045453)
Cytosol
(GO:0005829)
Eating behavior
(GO:0042755)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hormone activity
(GO:0005179)
Identical protein binding
(GO:0042802)
Inclusion body
(GO:0016234)
Lipid binding
(GO:0008289)
Negative regulation of bone resorption
(GO:0045779)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of osteoclast differentiation
(GO:0045671)
Osteoclast differentiation
(GO:0030316)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of camp-mediated signaling
(GO:0043950)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein kinase a signaling
(GO:0010739)
Protein destabilization
(GO:0031648)
Protein homooligomerization
(GO:0051260)
Receptor ligand activity
(GO:0048018)
Sensory perception of pain
(GO:0019233)
Signaling receptor binding
(GO:0005102)

Other Information

Proteins

Islet amyloid polypeptide

Genular Protein ID: 1815579566

Symbol: IAPP_MOUSE

Name: Islet amyloid polypeptide

UniProtKB Accession Codes:

P12968

Database IDs:

Citations:

PubMed ID: 2668946

Title: Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.

PubMed ID: 2668946

DOI: 10.1073/pnas.86.15.5738

PubMed ID: 9278863

Title: Cloning of mouse islet amyloid polypeptide gene and characterization of its promoter.

PubMed ID: 9278863

DOI: 10.1677/jme.0.0190079

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2666169

Title: Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species.

PubMed ID: 2666169

DOI: 10.1016/0014-5793(89)81467-x

Sequence Information:

Length: 93
Mass: 10022
Checksum: B135DBBC81475B15
Sequence:

MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA NFLVRSSNNL 
GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Iapp

Associated with

Other Information

Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. PubMed ID: 2668946

Cloning of mouse islet amyloid polypeptide gene and characterization of its promoter. PubMed ID: 9278863

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. PubMed ID: 2666169

Database document:

PubMed ID: 2668946

PubMed ID: 9278863

PubMed ID: 15489334

PubMed ID: 2666169