Details for: Icam1

Gene ID: 15894

Symbol: Icam1

Ensembl ID: ENSMUSG00000037405

Description: intercellular adhesion molecule 1

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Extracellular matrix organization
    (R-MMU-1474244)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Integrin cell surface interactions
    (R-MMU-216083)
  • Acute inflammatory response to antigenic stimulus
    (GO:0002438)
  • Adhesion of symbiont to host
    (GO:0044406)
  • Cell-cell adhesion
    (GO:0098609)
  • Cell adhesion
    (GO:0007155)
  • Cell adhesion mediated by integrin
    (GO:0033627)
  • Cell surface
    (GO:0009986)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Establishment of endothelial barrier
    (GO:0061028)
  • Establishment of endothelial intestinal barrier
    (GO:0090557)
  • Establishment of sertoli cell barrier
    (GO:0097368)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular space
    (GO:0005615)
  • Immunological synapse
    (GO:0001772)
  • Integrin binding
    (GO:0005178)
  • Leukocyte cell-cell adhesion
    (GO:0007159)
  • Membrane
    (GO:0016020)
  • Membrane raft
    (GO:0045121)
  • Negative regulation of calcium ion transport
    (GO:0051926)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902042)
  • Positive regulation of actin filament polymerization
    (GO:0030838)
  • Positive regulation of cellular extravasation
    (GO:0002693)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of leukocyte adhesion to vascular endothelial cell
    (GO:1904996)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Protein-containing complex binding
    (GO:0044877)
  • Receptor-mediated virion attachment to host cell
    (GO:0046813)
  • Regulation of cell shape
    (GO:0008360)
  • Regulation of ruffle assembly
    (GO:1900027)
  • T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:0002291)
  • T cell antigen processing and presentation
    (GO:0002457)
  • T cell extravasation
    (GO:0072683)

Other Information

Genular Protein ID: 3849128642

Symbol: ICAM1_MOUSE

Name: Intercellular adhesion molecule 1

UniProtKB Accession Codes:

P13597 Q61828

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2573511

Title: Molecular cloning of murine intercellular adhesion molecule (ICAM-1).

PubMed ID: 2573511

DOI: 10.1002/j.1460-2075.1989.tb08437.x

PubMed ID: 2479693

Title: Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

PubMed ID: 2479693

PubMed ID: 2762164

Title: Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1).

PubMed ID: 2762164

DOI: 10.1093/nar/17.14.5853

PubMed ID: 1362180

Title: Characterization of the murine Icam-1 gene.

PubMed ID: 1362180

DOI: 10.1016/s0888-7543(05)80132-6

PubMed ID: 1690380

Title: Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants.

PubMed ID: 1690380

PubMed ID: 9207125

Title: A new class of obesity genes encodes leukocyte adhesion receptors.

PubMed ID: 9207125

DOI: 10.1073/pnas.94.14.7526

PubMed ID: 16877748

Title: N-glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and FTICR mass spectrometry.

PubMed ID: 16877748

DOI: 10.1093/glycob/cwl032

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 537
  • Mass: 58844
  • Checksum: 6124167753774555
  • Sequence:
    • MASTRAKPTL PLLLALVTVV IPGPGDAQVS IHPREAFLPQ GGSVQVNCSS SCKEDLSLGL 
ETQWLKDELE SGPNWKLFEL SEIGEDSSPL CFENCGTVQS SASATITVYS FPESVELRPL 
PAWQQVGKDL TLRCHVDGGA PRTQLSAVLL RGEEILSRQP VGGHPKDPKE ITFTVLASRG 
DHGANFSCRT ELDLRPQGLA LFSNVSEARS LRTFDLPATI PKLDTPDLLE VGTQQKLFCS 
LEGLFPASEA RIYLELGGQM PTQESTNSSD SVSATALVEV TEEFDRTLPL RCVLELADQI 
LETQRTLTVY NFSAPVLTLS QLEVSEGSQV TVKCEAHSGS KVVLLSGVEP RPPTPQVQFT 
LNASSEDHKR SFFCSAALEV AGKFLFKNQT LELHVLYGPR LDETDCLGNW TWQEGSQQTL 
KCQAWGNPSP KMTCRRKADG ALLPIGVVKS VKQEMNGTYV CHAFSSHGNV TRNVYLTVLY 
HSQNNWTIII LVPVLLVIVG LVMAASYVYN RQRKIRIYKL QKAQEEAIKL KGQAPPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.