Details for: ADSS2

Gene ID: 159

Symbol: ADSS2

Ensembl ID: ENSG00000035687

Description: adenylosuccinate synthase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.88
    Marker Score: 2571
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.85
    Marker Score: 4980.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.91
    Marker Score: 14248
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.83
    Marker Score: 1930
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.76
    Marker Score: 23655
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.72
    Marker Score: 4235
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.71
    Marker Score: 4090
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.68
    Marker Score: 1228
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.65
    Marker Score: 821
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.63
    Marker Score: 14155
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.61
    Marker Score: 695
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15157
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.53
    Marker Score: 1974
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.53
    Marker Score: 2251
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.49
    Marker Score: 5138
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.49
    Marker Score: 2141
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91520
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12747
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.44
    Marker Score: 13554
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.42
    Marker Score: 49081
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.39
    Marker Score: 2462
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.38
    Marker Score: 16097
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.37
    Marker Score: 333
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50235
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.35
    Marker Score: 1916
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.35
    Marker Score: 1490
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2071
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.34
    Marker Score: 1345
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.34
    Marker Score: 703
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.33
    Marker Score: 782
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3
    Marker Score: 1754
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.29
    Marker Score: 1186
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.28
    Marker Score: 857.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.27
    Marker Score: 929
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.26
    Marker Score: 365
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.26
    Marker Score: 1332
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.26
    Marker Score: 718
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.24
    Marker Score: 2350.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.24
    Marker Score: 821.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.23
    Marker Score: 24551
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.21
    Marker Score: 950
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2
    Marker Score: 12352
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.19
    Marker Score: 11807
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.19
    Marker Score: 4857
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1478
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.18
    Marker Score: 1425
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.18
    Marker Score: 1268
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.18
    Marker Score: 2965
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.17
    Marker Score: 5040
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.16
    Marker Score: 917
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.16
    Marker Score: 678
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.16
    Marker Score: 777
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.16
    Marker Score: 1234
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.16
    Marker Score: 2418
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.16
    Marker Score: 392
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.15
    Marker Score: 275
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.15
    Marker Score: 331
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.15
    Marker Score: 1191
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.14
    Marker Score: 444
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.14
    Marker Score: 17080
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.13
    Marker Score: 440
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.13
    Marker Score: 1144
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.13
    Marker Score: 14981
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.12
    Marker Score: 619
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.12
    Marker Score: 1217
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.12
    Marker Score: 1485
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.11
    Marker Score: 3023.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.11
    Marker Score: 1886
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.11
    Marker Score: 4358
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.1
    Marker Score: 246
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.1
    Marker Score: 1911
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.1
    Marker Score: 382
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.09
    Marker Score: 6983
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 510
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.09
    Marker Score: 2118
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.09
    Marker Score: 213
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.08
    Marker Score: 378
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.08
    Marker Score: 236
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1157
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.07
    Marker Score: 9248
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40750
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.07
    Marker Score: 4147
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.06
    Marker Score: 2426
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.06
    Marker Score: 2940
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.06
    Marker Score: 262
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.05
    Marker Score: 8052
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.05
    Marker Score: 425
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.05
    Marker Score: 1141
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.04
    Marker Score: 475
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.04
    Marker Score: 880
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2458
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.03
    Marker Score: 242
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.03
    Marker Score: 4277
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.03
    Marker Score: 2515
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.03
    Marker Score: 504
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2051
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.02
    Marker Score: 271
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.02
    Marker Score: 696
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.02
    Marker Score: 498
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.02
    Marker Score: 245

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Other Information

**Key characteristics:** - ADSS2 is a transmembrane protein with a single transmembrane domain. - It is expressed in a variety of cell types. - It is a key enzyme in the 'de novo' amp biosynthetic process. **Pathways and functions:** - The 'de novo' amp biosynthetic process is a multi-step pathway that involves the sequential addition of nucleotides to a growing polyadenylate chain. - ADSS2 is one of the enzymes that participates in this process. - It is responsible for the formation of the coenzyme A-AMP, which is essential for the subsequent steps of the process. **Clinical significance:** - Mutations in ADSS2 have been linked to several human diseases, including cancer and neurodegenerative disorders. - ADSS2 inhibitors are being investigated as potential therapies for these diseases. **Additional information:** - The accession number for ADSS2 is ENSG00000035687. - It is a protein of the adenylate cyclase superfamily. - It is a highly conserved protein with significant sequence similarity in mammals.

Genular Protein ID: 3005298788

Symbol: PURA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30520 B1AQM5 Q96EG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 2 HAMAP-Rule 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1592113

Title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.

PubMed ID: 1592113

DOI: 10.1016/0014-5793(92)80465-s

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 456
  • Mass: 50097
  • Checksum: 23B7AAC58A238783
  • Sequence:
    • MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL AQDADIVCRC 
QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV IHLPGLFEEA EKNVQKGKGL 
EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ RQEQAGKNLG TTKKGIGPVY SSKAARSGLR 
MCDLVSDFDG FSERFKVLAN QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE 
ALHGPPKKIL VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY 
TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH MINGFTALAL 
TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV QYKTLPGWNT DISNARAFKE 
LPVNAQNYVR FIEDELQIPV KWIGVGKSRE SMIQLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.