Details for: ADSS2

Gene ID: 159

Symbol: ADSS2

Ensembl ID: ENSG00000035687

Description: adenylosuccinate synthase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.1377
    Cell Significance Index: -38.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.4514
    Cell Significance Index: -34.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.0845
    Cell Significance Index: -37.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.4275
    Cell Significance Index: -43.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.8562
    Cell Significance Index: -42.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.5806
    Cell Significance Index: -43.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.5499
    Cell Significance Index: -37.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.1399
    Cell Significance Index: -40.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6985
    Cell Significance Index: -32.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5067
    Cell Significance Index: -41.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4633
    Cell Significance Index: 243.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4525
    Cell Significance Index: 291.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2405
    Cell Significance Index: 33.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0820
    Cell Significance Index: 195.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0281
    Cell Significance Index: 126.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9044
    Cell Significance Index: 46.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8857
    Cell Significance Index: 483.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8202
    Cell Significance Index: 112.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7719
    Cell Significance Index: 153.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6763
    Cell Significance Index: 610.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6709
    Cell Significance Index: 31.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6376
    Cell Significance Index: 281.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5518
    Cell Significance Index: 197.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5220
    Cell Significance Index: 29.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5209
    Cell Significance Index: 26.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5123
    Cell Significance Index: 7.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3713
    Cell Significance Index: 17.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3643
    Cell Significance Index: 47.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3613
    Cell Significance Index: 9.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3492
    Cell Significance Index: 24.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3172
    Cell Significance Index: 20.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2632
    Cell Significance Index: 7.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2501
    Cell Significance Index: 32.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2429
    Cell Significance Index: 28.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2085
    Cell Significance Index: 7.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2052
    Cell Significance Index: 1.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1925
    Cell Significance Index: 4.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1696
    Cell Significance Index: 7.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1651
    Cell Significance Index: 7.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1629
    Cell Significance Index: 112.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1620
    Cell Significance Index: 12.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0911
    Cell Significance Index: 14.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0907
    Cell Significance Index: 17.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0803
    Cell Significance Index: 6.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0740
    Cell Significance Index: 136.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0687
    Cell Significance Index: 105.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0546
    Cell Significance Index: 1.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0307
    Cell Significance Index: 2.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0259
    Cell Significance Index: 48.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0098
    Cell Significance Index: 6.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0061
    Cell Significance Index: -2.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0246
    Cell Significance Index: -18.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0545
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0574
    Cell Significance Index: -42.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0665
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0699
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0723
    Cell Significance Index: -45.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0726
    Cell Significance Index: -40.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0761
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0766
    Cell Significance Index: -0.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1164
    Cell Significance Index: -33.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1277
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1280
    Cell Significance Index: -21.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1325
    Cell Significance Index: -19.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1409
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1766
    Cell Significance Index: -20.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1785
    Cell Significance Index: -3.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1986
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2152
    Cell Significance Index: -45.3200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2459
    Cell Significance Index: -3.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2734
    Cell Significance Index: -4.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2813
    Cell Significance Index: -5.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2848
    Cell Significance Index: -7.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3400
    Cell Significance Index: -8.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3421
    Cell Significance Index: -37.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3541
    Cell Significance Index: -36.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3763
    Cell Significance Index: -23.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3802
    Cell Significance Index: -7.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4134
    Cell Significance Index: -32.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4238
    Cell Significance Index: -22.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5271
    Cell Significance Index: -13.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5285
    Cell Significance Index: -32.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5517
    Cell Significance Index: -9.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6631
    Cell Significance Index: -13.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6894
    Cell Significance Index: -21.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7324
    Cell Significance Index: -30.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7395
    Cell Significance Index: -21.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7401
    Cell Significance Index: -24.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7413
    Cell Significance Index: -18.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7534
    Cell Significance Index: -15.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8696
    Cell Significance Index: -24.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8823
    Cell Significance Index: -32.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8860
    Cell Significance Index: -31.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9134
    Cell Significance Index: -18.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9459
    Cell Significance Index: -16.2100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.0116
    Cell Significance Index: -6.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADSS2 is a gene that encodes for a protein, PURA2_HUMAN, which belongs to the purine ribonucleoside monophosphate biosynthetic pathway. The gene is significantly expressed in various cell types, including extravillous trophoblast, germ cells, and immune cells such as effector memory CD4-positive, alpha-beta T cells. ADSS2 is also found in tissues involved in metabolism, such as the liver and kidneys. **Pathways and Functions:** ADSS2 is involved in several cellular processes, including the de novo synthesis of adenine nucleotides, the metabolism of aspartate, and the regulation of the immune response. The gene is part of the AMP biosynthetic process, which is crucial for energy production and cellular homeostasis. ADSS2 also plays a role in the response to electrical stimuli, oxidative stress, and the regulation of magnesium ion binding. Furthermore, the gene is involved in the metabolism of purines, which are essential for the synthesis of nucleic acids and the maintenance of cellular homeostasis. **Clinical Significance:** ADSS2 has been implicated in various diseases, including cancer, autoimmune disorders, and metabolic disorders. The gene's involvement in the immune response and metabolism suggests that it may play a significant role in the development and progression of these diseases. For instance, ADSS2 has been found to be overexpressed in malignant cells, suggesting its potential as a biomarker for cancer diagnosis and prognosis. Additionally, the gene's involvement in the regulation of the immune response makes it a potential target for the development of immunotherapies. **Implications and Future Directions:** Further research is necessary to fully elucidate the role of ADSS2 in human disease. The gene's involvement in multiple cellular processes suggests that it may be a key regulator of cellular homeostasis. Investigating the molecular mechanisms underlying ADSS2's functions may provide insights into the development of novel therapeutic strategies for diseases associated with this gene. Additionally, the gene's expression in various cell types and tissues suggests that it may play a role in the development of tissue-specific diseases, such as those affecting the cardiovascular system or the nervous system. In conclusion, ADSS2 is a gene of emerging importance in immunology and metabolism, with implications for the development of novel therapeutic strategies for diseases associated with this gene. Further research is necessary to fully elucidate the role of ADSS2 in human disease and to explore its potential as a biomarker for disease diagnosis and prognosis.

Genular Protein ID: 3005298788

Symbol: PURA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30520 B1AQM5 Q96EG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1592113

Title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.

PubMed ID: 1592113

DOI: 10.1016/0014-5793(92)80465-s

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 456
  • Mass: 50097
  • Checksum: 23B7AAC58A238783
  • Sequence:
    • MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL AQDADIVCRC 
QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV IHLPGLFEEA EKNVQKGKGL 
EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ RQEQAGKNLG TTKKGIGPVY SSKAARSGLR 
MCDLVSDFDG FSERFKVLAN QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE 
ALHGPPKKIL VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY 
TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH MINGFTALAL 
TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV QYKTLPGWNT DISNARAFKE 
LPVNAQNYVR FIEDELQIPV KWIGVGKSRE SMIQLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.