Details for: Irf8

Gene ID: 15900

Symbol: Irf8

Ensembl ID: ENSMUSG00000041515

Description: interferon regulatory factor 8

Associated with

  • Autophagy
    (GO:0006914)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cytoplasm
    (GO:0005737)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to protozoan
    (GO:0042832)
  • Dendritic cell differentiation
    (GO:0097028)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Follicular b cell differentiation
    (GO:0002316)
  • Germinal center b cell differentiation
    (GO:0002314)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Interleukin-12 production
    (GO:0032615)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Phagocytosis
    (GO:0006909)
  • Plasmacytoid dendritic cell differentiation
    (GO:0002273)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of type i interferon production
    (GO:0032479)
  • Response to bacterium
    (GO:0009617)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Type ii interferon production
    (GO:0032609)

Other Information

Genular Protein ID: 1415081004

Symbol: IRF8_MOUSE

Name: N/A

UniProtKB Accession Codes:

P23611

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 33 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2111015

Title: An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

PubMed ID: 2111015

DOI: 10.1073/pnas.87.10.3743

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12461077

Title: ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells.

PubMed ID: 12461077

DOI: 10.1084/jem.20021263

PubMed ID: 12393690

Title: Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells.

PubMed ID: 12393690

DOI: 10.1182/blood-2002-04-1088

PubMed ID: 12538667

Title: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells.

PubMed ID: 12538667

DOI: 10.4049/jimmunol.170.3.1131

PubMed ID: 17579016

Title: Autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages.

PubMed ID: 17579016

DOI: 10.4049/jimmunol.179.1.26

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22992524

Title: Compensatory dendritic cell development mediated by BATF-IRF interactions.

PubMed ID: 22992524

DOI: 10.1038/nature11531

PubMed ID: 23382217

Title: Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.

PubMed ID: 23382217

DOI: 10.1073/pnas.1222798110

PubMed ID: 32741026

Title: Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression.

PubMed ID: 32741026

DOI: 10.1096/fj.202001197r

Sequence Information:

  • Length: 424
  • Mass: 48237
  • Checksum: FBE79A76846E8EB2
  • Sequence:
    • MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN DEKTMFRIPW KHAGKQDYNQ EVDASIFKAW 
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC 
KLGVAPAGCM SEVPEMECGR SEIEELIKEP SVDEYMGMTK RSPSPPEACR SQILPDWWVQ 
QPSAGLPLVT GYAAYDTHHS AFSQMVISFY YGGKLVGQAT TTCLEGCRLS LSQPGLPKLY 
GPDGLEPVCF PTADTIPSER QRQVTRKLFG HLERGVLLHS NRKGVFVKRL CQGRVFCSGN 
AVVCKGRPNK LERDEVVQVF DTNQFIRELQ QFYATQSRLP DSRVVLCFGE EFPDTVPLRS 
KLILVQVEQL YARQLVEEAG KSCGAGSLMP ALEEPQPDQA FRMFPDICTS HQRPFFRENQ 
QITV

Genular Protein ID: 1139334580

Symbol: Q3UCV9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UCV9

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 424
  • Mass: 48271
  • Checksum: FCCA2B3D56227301
  • Sequence:
    • MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN DEKTMFRIPW KHAGKQDYNQ EVDASIFKAW 
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDFSEPYKVY RIVPEEEQKC 
KLGVAPAGCM SEVPEMECGR SEIEELIKEP SVDEYMGMTK RSPSPPEACR SQILPDWWVQ 
QPSAGLPLVT GYAAYDTHHS AFSQMVISFY YGGKLVGQAT TTCLEGCRLS LSQPGLPKLY 
GPDGLEPVCF PTADTIPSER QRQVTRKLFG HLERGVLLHS NRKGVFVKRL CQGRVFCSGN 
AVVCKGRPNK LERDEVVQVF DTNQFIRELQ QFYATQSRLP DSRVVLCFGE EFPDTVPLRS 
KLILVQVEQL YARQLVEEAG KSCGAGSLMP ALEEPQPDQA FRMFPDICTS HQRPFFRENQ 
QITV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.