Genular: Defining Cellular Identity and Function

Details for: Id2

Gene ID: 15902

Symbol: Id2

Ensembl ID: ENSMUSG00000020644

Description: inhibitor of DNA binding 2

Associated with

Adipose tissue development
(GO:0060612)
Adult locomotory behavior
(GO:0008344)
Astrocyte differentiation
(GO:0048708)
B cell differentiation
(GO:0030183)
Bundle of his development
(GO:0003166)
Cell development
(GO:0048468)
Cell differentiation
(GO:0030154)
Cell maturation
(GO:0048469)
Cell morphogenesis involved in neuron differentiation
(GO:0048667)
Cellular response to lithium ion
(GO:0071285)
Cellular senescence
(GO:0090398)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dopaminergic neuron differentiation
(GO:0071542)
Embryonic digestive tract morphogenesis
(GO:0048557)
Endodermal digestive tract morphogenesis
(GO:0061031)
Entrainment of circadian clock
(GO:0009649)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Enucleate erythrocyte differentiation
(GO:0043353)
Epithelial cell differentiation involved in mammary gland alveolus development
(GO:0061030)
Erythrocyte differentiation
(GO:0030218)
Euchromatin
(GO:0000791)
Heart development
(GO:0007507)
Leukocyte differentiation
(GO:0002521)
Locomotor rhythm
(GO:0045475)
Lymph node development
(GO:0048535)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Membranous septum morphogenesis
(GO:0003149)
Metanephros development
(GO:0001656)
Multicellular organism development
(GO:0007275)
Natural killer cell differentiation
(GO:0001779)
Negative regulation of b cell differentiation
(GO:0045578)
Negative regulation of core promoter binding
(GO:1904797)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of dopaminergic neuron differentiation
(GO:1904339)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of muscle cell differentiation
(GO:0051148)
Negative regulation of oligodendrocyte differentiation
(GO:0048715)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron fate commitment
(GO:0048663)
Nucleus
(GO:0005634)
Olfactory bulb development
(GO:0021772)
Oligodendrocyte development
(GO:0014003)
Oligodendrocyte differentiation
(GO:0048709)
Peyer's patch development
(GO:0048541)
Positive regulation of astrocyte differentiation
(GO:0048711)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of circadian rhythm
(GO:0042752)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of gene expression
(GO:0010468)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of neuron differentiation
(GO:0045664)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Thigmotaxis
(GO:0001966)
Transcription regulator activity
(GO:0140110)
Transcription regulator inhibitor activity
(GO:0140416)
Transmembrane transporter binding
(GO:0044325)
White fat cell differentiation
(GO:0050872)

Other Information

Proteins

DNA-binding protein inhibitor ID-2

Genular Protein ID: 666179763

Symbol: ID2_MOUSE

Name: DNA-binding protein inhibitor ID-2

UniProtKB Accession Codes:

P41136 O88604

Database IDs:

Citations:

PubMed ID: 1922066

Title: Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

PubMed ID: 1922066

DOI: 10.1128/mcb.11.11.5603-5611.1991

PubMed ID: 9831657

Title: The mouse Id2 and Id4 genes: structural organization and chromosomal localization.

PubMed ID: 9831657

DOI: 10.1016/s0378-1119(98)00488-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11940648

Title: The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.

PubMed ID: 11940648

DOI: 10.1128/mcb.22.9.2893-2905.2002

PubMed ID: 15563451

Title: Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors.

PubMed ID: 15563451

DOI: 10.1074/jbc.m412614200

PubMed ID: 16556596

Title: p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.

PubMed ID: 16556596

DOI: 10.1074/jbc.m511748200

PubMed ID: 19217292

Title: A role for Id2 in regulating photic entrainment of the mammalian circadian system.

PubMed ID: 19217292

DOI: 10.1016/j.cub.2008.12.052

PubMed ID: 19740747

Title: ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver.

PubMed ID: 19740747

DOI: 10.1074/jbc.m109.013961

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

Sequence Information:

Length: 134
Mass: 14959
Checksum: A0D98D54F2686CC5
Sequence:

MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVT 
KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF 
PSELMSNDSK VLCG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Id2

Associated with

Other Information

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. PubMed ID: 1922066

The mouse Id2 and Id4 genes: structural organization and chromosomal localization. PubMed ID: 9831657

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins. PubMed ID: 11940648

Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors. PubMed ID: 15563451

p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins. PubMed ID: 16556596

A role for Id2 in regulating photic entrainment of the mammalian circadian system. PubMed ID: 19217292

ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. PubMed ID: 19740747

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. PubMed ID: 20861012