Genular: Defining Cellular Identity and Function

Details for: Idh1

Gene ID: 15926

Symbol: Idh1

Ensembl ID: ENSMUSG00000025950

Description: isocitrate dehydrogenase 1 (NADP+), soluble

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of cofactors
(R-MMU-8978934)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Nadph regeneration
(R-MMU-389542)
Neutrophil degranulation
(R-MMU-6798695)
Peroxisomal protein import
(R-MMU-9033241)
Protein localization
(R-MMU-9609507)
2-oxoglutarate metabolic process
(GO:0006103)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glutathione metabolic process
(GO:0006749)
Glyoxylate cycle
(GO:0006097)
Identical protein binding
(GO:0042802)
Isocitrate dehydrogenase (nadp+) activity
(GO:0004450)
Isocitrate metabolic process
(GO:0006102)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Nad binding
(GO:0051287)
Nadp binding
(GO:0050661)
Nadp metabolic process
(GO:0006739)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Peroxisome
(GO:0005777)
Protein homodimerization activity
(GO:0042803)
Regulation of phospholipid biosynthetic process
(GO:0071071)
Regulation of phospholipid catabolic process
(GO:0060696)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Response to steroid hormone
(GO:0048545)
Tricarboxylic acid cycle
(GO:0006099)

Other Information

Proteins

Isocitrate dehydrogenase [NADP] cytoplasmic

Genular Protein ID: 1517483423

Symbol: IDHC_MOUSE

Name: Isocitrate dehydrogenase [NADP] cytoplasmic

UniProtKB Accession Codes:

O88844 Q3UAV7

Database IDs:

Citations:

PubMed ID: 9866202

Title: Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.

PubMed ID: 9866202

DOI: 10.1093/oxfordjournals.molbev.a025894

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12031902

Title: Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells.

PubMed ID: 12031902

DOI: 10.1016/s0891-5849(02)00815-8

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 29923039

Title: NADP(+)-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione.

PubMed ID: 29923039

DOI: 10.1007/s00775-018-1581-5

Sequence Information:

Length: 414
Mass: 46674
Checksum: C7FEF315D042C44C
Sequence:

MSRKIQGGSV VEMQGDEMTR IIWELIKEKL ILPYVELDLH SYDLGIENRD ATNDQVTKDA 
AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 
VTGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPKD GTQKVTYMVH DFEEGGGVAM 
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKKYKSQFE 
AQKICYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLICPDG 
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWSRGL AHRAKLDNNT ELSFFAKALE 
DVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKAKLA QAKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Idh1

Associated with

Other Information

Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. PubMed ID: 9866202

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. PubMed ID: 12031902

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

NADP(+)-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione. PubMed ID: 29923039