Genular: Defining Cellular Identity and Function

Details for: Ido1

Gene ID: 15930

Symbol: Ido1

Ensembl ID: ENSMUSG00000031551

Description: indoleamine 2,3-dioxygenase 1

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Tryptophan catabolism
(R-MMU-71240)
'de novo' nad biosynthetic process from tryptophan
(GO:0034354)
Amino acid binding
(GO:0016597)
Cytokine production involved in inflammatory response
(GO:0002534)
Cytoplasm
(GO:0005737)
Defense response
(GO:0006952)
Dioxygenase activity
(GO:0051213)
Heme binding
(GO:0020037)
Immune system process
(GO:0002376)
Indoleamine 2,3-dioxygenase activity
(GO:0033754)
Inflammatory response
(GO:0006954)
Interleukin-10 production
(GO:0032613)
Interleukin-12 production
(GO:0032615)
Kynurenic acid biosynthetic process
(GO:0034276)
Metal ion binding
(GO:0046872)
Multicellular organismal response to stress
(GO:0033555)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of t cell apoptotic process
(GO:0070233)
Negative regulation of t cell proliferation
(GO:0042130)
Oxidoreductase activity
(GO:0016491)
Oxygen binding
(GO:0019825)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of chronic inflammatory response
(GO:0002678)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of t cell apoptotic process
(GO:0070234)
Positive regulation of t cell tolerance induction
(GO:0002666)
Positive regulation of type 2 immune response
(GO:0002830)
Protein binding
(GO:0005515)
Response to lipopolysaccharide
(GO:0032496)
Smooth muscle contractile fiber
(GO:0030485)
Stereocilium bundle
(GO:0032421)
Swimming behavior
(GO:0036269)
T cell proliferation
(GO:0042098)
Tryptophan 2,3-dioxygenase activity
(GO:0004833)
Tryptophan catabolic process
(GO:0006569)
Tryptophan catabolic process to kynurenine
(GO:0019441)

Other Information

Proteins

Indoleamine 2,3-dioxygenase 1
D3YXV1_MOUSE

Genular Protein ID: 2613866326

Symbol: I23O1_MOUSE

Name: Indoleamine 2,3-dioxygenase 1

UniProtKB Accession Codes:

P28776

Database IDs:

Citations:

PubMed ID: 1937018

Title: Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase.

PubMed ID: 1937018

DOI: 10.1016/0378-1119(91)90154-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15063630

Title: Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific.

PubMed ID: 15063630

DOI: 10.1016/j.jri.2003.11.003

PubMed ID: 18026683

Title: Evolution of vertebrate indoleamine 2,3-dioxygenases.

PubMed ID: 18026683

DOI: 10.1007/s00239-007-9049-1

PubMed ID: 18384884

Title: Normal development and function of dendritic cells in mice lacking IDO-1 expression.

PubMed ID: 18384884

DOI: 10.1016/j.imlet.2008.02.006

PubMed ID: 19741271

Title: Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions.

PubMed ID: 19741271

DOI: 10.1369/jhc.2009.953604

PubMed ID: 22157149

Title: Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase.

PubMed ID: 22157149

DOI: 10.4161/cbt.12.12.18142

PubMed ID: 25691885

Title: Tryptophan-degrading enzymes in tumoral immune resistance.

PubMed ID: 25691885

DOI: 10.3389/fimmu.2015.00034

Sequence Information:

Length: 407
Mass: 45641
Checksum: 317681EABF96A727
Sequence:

MALSKISPTE GSRRILEDHH IDEDVGFALP HPLVELPDAY SPWVLVARNL PVLIENGQLR 
EEVEKLPTLS TDGLRGHRLQ RLAHLALGYI TMAYVWNRGD DDVRKVLPRN IAVPYCELSE 
KLGLPPILSY ADCVLANWKK KDPNGPMTYE NMDILFSFPG GDCDKGFFLV SLLVEIAASP 
AIKAIPTVSS AVERQDLKAL EKALHDIATS LEKAKEIFKR MRDFVDPDTF FHVLRIYLSG 
WKCSSKLPEG LLYEGVWDTP KMFSGGSAGQ SSIFQSLDVL LGIKHEAGKE SPAEFLQEMR 
EYMPPAHRNF LFFLESAPPV REFVISRHNE DLTKAYNECV NGLVSVRKFH LAIVDTYIMK 
PSKKKPTDGD KSEEPSNVES RGTGGTNPMT FLRSVKDTTE KALLSWP

Genular Protein ID: 4067864232

Symbol: D3YXV1_MOUSE

Name: N/A

UniProtKB Accession Codes:

D3YXV1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 316
Mass: 35463
Checksum: 173038D5E4A0516E
Sequence:

MAYVWNRGDD DVRKVLPRNI AVPYCELSEK LGLPPILSYA DCVLANWKKK DPNGPMTYEN 
MDILFSFPGG DCDKGFFLVS LLVEIAASPA IKAIPTVSSA VERQDLKALE KALHDIATSL 
EKAKEIFKRM RDFVDPDTFF HVLRIYLSGW KCSSKLPEGL LYEGVWDTPK MFSGGSAGQS 
SIFQSLDVLL GIKHEAGKES PAEFLQEMRE YMPPAHRNFL FFLESAPPVR EFVISRHNED 
LTKAYNECVN GLVSVRKFHL AIVDTYIMKP SKKKPTDGDK SEEPSNVESR GTGGTNPMTF 
LRSVKDTTEK ALLSWP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ido1

Associated with

Other Information

Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase. PubMed ID: 1937018

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. PubMed ID: 15063630

Evolution of vertebrate indoleamine 2,3-dioxygenases. PubMed ID: 18026683

Normal development and function of dendritic cells in mice lacking IDO-1 expression. PubMed ID: 18384884

Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions. PubMed ID: 19741271

Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase. PubMed ID: 22157149

Tryptophan-degrading enzymes in tumoral immune resistance. PubMed ID: 25691885

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303