Details for: Irgm1
Associated with
Other Information
Genular Protein ID: 186157172
Symbol: IRGM1_MOUSE
Name: Interferon-inducible GTPase 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7561525
Title: Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family.
PubMed ID: 7561525
DOI: 10.1002/jlb.58.4.477
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11457893
Title: Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.
PubMed ID: 11457893
PubMed ID: 14576437
Title: Immune control of tuberculosis by IFN-gamma-inducible LRG-47.
PubMed ID: 14576437
PubMed ID: 15607973
Title: Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
PubMed ID: 15607973
PubMed ID: 14707092
Title: Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.
PubMed ID: 14707092
PubMed ID: 15294976
Title: Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis.
PubMed ID: 15294976
PubMed ID: 15908352
Title: p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.
PubMed ID: 15908352
PubMed ID: 16339555
Title: Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.
PubMed ID: 16339555
PubMed ID: 17911638
Title: The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
PubMed ID: 17911638
PubMed ID: 17982087
Title: Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).
PubMed ID: 17982087
PubMed ID: 18371424
Title: The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
PubMed ID: 18371424
PubMed ID: 18806793
Title: The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.
PubMed ID: 18806793
DOI: 10.1038/ni.1653
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 19620982
Title: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.
PubMed ID: 19620982
DOI: 10.1038/ni.1759
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 19920210
PubMed ID: 20072621
Title: Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.
PubMed ID: 20072621
PubMed ID: 21633090
Title: Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
PubMed ID: 21633090
PubMed ID: 21757726
Title: Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
PubMed ID: 21757726
PubMed ID: 22874556
Title: Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.
PubMed ID: 22874556
DOI: 10.4161/auto.21561
PubMed ID: 23785284
Title: IRG and GBP host resistance factors target aberrant, 'non-self' vacuoles characterized by the missing of 'self' IRGM proteins.
PubMed ID: 23785284
PubMed ID: 24751652
Title: Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.
PubMed ID: 24751652
PubMed ID: 27439214
Title: Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development.
PubMed ID: 27439214
PubMed ID: 27098192
Title: Loss of the interferon-gamma-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
PubMed ID: 27098192
PubMed ID: 28154172
Title: Metabolic alterations contribute to enhanced inflammatory cytokine production in Irgm1-deficient macrophages.
PubMed ID: 28154172
PubMed ID: 28814662
Title: Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
PubMed ID: 28814662
PubMed ID: 27443879
Title: Irgm1 is required for the inflammatory function of M1 macrophage in early experimental autoimmune encephalomyelitis.
PubMed ID: 27443879
PubMed ID: 30612879
Title: The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy.
PubMed ID: 30612879
PubMed ID: 32715615
Title: Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
PubMed ID: 32715615
PubMed ID: 32453761
Title: Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.
PubMed ID: 32453761
PubMed ID: 34467632
Title: Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses.
PubMed ID: 34467632
PubMed ID: 33510463
Title: IRGM1 links mitochondrial quality control to autoimmunity.
PubMed ID: 33510463
PubMed ID: 35197566
Title: Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis.
PubMed ID: 35197566
PubMed ID: 36629440
Title: Differential requirement for IRGM proteins during Tuberculosis infection in mice.
PubMed ID: 36629440
DOI: 10.1128/iai.00510-22
Sequence Information:
- Length: 409
- Mass: 46552
- Checksum: E4913367193059B6
- Sequence:
MKPSHSSCEA APLLPNMAET HYAPLSSAFP FVTSYQTGSS RLPEVSRSTE RALREGKLLE LVYGIKETVA TLSQIPVSIF VTGDSGNGMS SFINALRVIG HDEDASAPTG VVRTTKTRTE YSSSHFPNVV LWDLPGLGAT AQTVEDYVEE MKFSTCDLFI IIASEQFSSN HVKLSKIIQS MGKRFYIVWT KLDRDLSTSV LSEVRLLQNI QENIRENLQK EKVKYPPVFL VSSLDPLLYD FPKLRDTLHK DLSNIRCCEP LKTLYGTYEK IVGDKVAVWK QRIANESLKN SLGVRDDDNM GECLKVYRLI FGVDDESVQQ VAQSMGTVVM EYKDNMKSQN FYTLRREDWK LRLMTCAIVN AFFRLLRFLP CVCCCLRRLR HKRMLFLVAQ DTKNILEKIL RDSIFPPQI
Genular Protein ID: 944607876
Symbol: J7NUP1_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 22892676
Title: Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases.
PubMed ID: 22892676
PubMed ID: 26862561
Title: Curated eutherian third party data gene data sets.
PubMed ID: 26862561
Title: Eutherian third-party data gene collections.
Sequence Information:
- Length: 393
- Mass: 44888
- Checksum: AA29EED4F483B044
- Sequence:
MAETHYAPLS SAFPFVTSYQ TGSSRLPEVS RSTERALREG KLLELVYGIK ETVATLSQIP VSIFVTGDSG NGMSSFINAL RVIGHDEDAS APTGVVRTTK TRTEYSSSHF PNVVLWDLPG LGATAQTVED YVEEMKFSTC DLFIIIASEQ FSSNHVKLSK IIQSMGKRFY IVWTKLDRDL STSVLSEVRL LQNIQENIRE NLQKEKVKYP PVFLVSSLDP LLYDFPKLRD TLHKDLSNIR CCEPLKTLYG TYEKIVGDKV AVWKQRIANE SLKNSLGVRD DDNMGECLKV YRLIFGVDDE SVQQVAQSMG TVVMEYKDNM KSQNFYTLRR EDWKLRLMTC AIVNAFFRLL RFLPCVCCCL RRLRHKRMLF LVAQDTKNIL EKILRDSIFP PQI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.