Genular: Defining Cellular Identity and Function

Details for: Cxcl10

Gene ID: 15945

Symbol: Cxcl10

Ensembl ID: ENSMUSG00000034855

Description: C-X-C motif chemokine ligand 10

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cellular response to interleukin-17
(GO:0097398)
Cellular response to lipopolysaccharide
(GO:0071222)
Chemoattractant activity
(GO:0042056)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cxcr3 chemokine receptor binding
(GO:0048248)
Cxcr chemokine receptor binding
(GO:0045236)
Cytokine activity
(GO:0005125)
Defense response
(GO:0006952)
Defense response to virus
(GO:0051607)
Endothelial cell activation
(GO:0042118)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heparin binding
(GO:0008201)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Killing of cells of another organism
(GO:0031640)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of myoblast fusion
(GO:1901740)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Positive regulation of t cell migration
(GO:2000406)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell population proliferation
(GO:0042127)
Regulation of endothelial tube morphogenesis
(GO:1901509)
Regulation of t cell chemotaxis
(GO:0010819)
Response to bacterium
(GO:0009617)
T cell chemotaxis
(GO:0010818)

Other Information

Proteins

C-X-C motif chemokine 10

Genular Protein ID: 3186038520

Symbol: CXL10_MOUSE

Name: C-X-C motif chemokine 10

UniProtKB Accession Codes:

P17515

Database IDs:

Citations:

PubMed ID: 2189406

Title: A macrophage LPS-inducible early gene encodes the murine homologue of IP-10.

PubMed ID: 2189406

DOI: 10.1016/0006-291x(90)91164-n

PubMed ID: 2118520

Title: Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine.

PubMed ID: 2118520

DOI: 10.1016/s0021-9258(18)77222-0

PubMed ID: 8454640

Title: Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

PubMed ID: 8454640

DOI: 10.1016/s0021-9258(18)53303-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8145049

Title: Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes.

PubMed ID: 8145049

DOI: 10.1084/jem.179.4.1373

PubMed ID: 15456824

Title: CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion.

PubMed ID: 15456824

DOI: 10.1523/jneurosci.2451-04.2004

PubMed ID: 18624292

Title: CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy.

PubMed ID: 18624292

DOI: 10.1002/eji.200838155

PubMed ID: 19017990

Title: Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection.

PubMed ID: 19017990

DOI: 10.4049/jimmunol.181.11.7985

PubMed ID: 28468883

Title: CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease.

PubMed ID: 28468883

DOI: 10.1128/jvi.00278-17

PubMed ID: 28623423

Title: CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13.

PubMed ID: 28623423

DOI: 10.1007/s10456-017-9561-x

PubMed ID: 18560148

Title: Structure of mouse IP-10, a chemokine.

PubMed ID: 18560148

DOI: 10.1107/s0907444908007026

Sequence Information:

Length: 98
Mass: 10789
Checksum: 42B0E6A0CC56FE36
Sequence:

MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI IPASLSCPRV 
EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cxcl10

Associated with

Other Information

A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. PubMed ID: 2189406

Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. PubMed ID: 2118520

Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. PubMed ID: 8454640

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes. PubMed ID: 8145049

CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. PubMed ID: 15456824

CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. PubMed ID: 18624292

Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. PubMed ID: 19017990

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease. PubMed ID: 28468883

CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13. PubMed ID: 28623423

Structure of mouse IP-10, a chemokine. PubMed ID: 18560148