Genular: Defining Cellular Identity and Function

Details for: Ifi204

Gene ID: 15951

Symbol: Ifi204

Ensembl ID: ENSMUSG00000073489

Description: interferon activated gene 204

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Activation of innate immune response
(GO:0002218)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to interferon-alpha
(GO:0035457)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to ionizing radiation
(GO:0071479)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Inner ear development
(GO:0048839)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Monocyte differentiation
(GO:0030224)
Multicellular organism development
(GO:0007275)
Negative regulation of aim2 inflammasome complex assembly
(GO:0140972)
Negative regulation of cysteine-type endopeptidase activity
(GO:2000117)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of viral genome replication
(GO:0045071)
Nuclear inclusion body
(GO:0042405)
Nuclear speck
(GO:0016607)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to bacterium
(GO:0009617)
Transcription coregulator activity
(GO:0003712)
Transcription factor binding
(GO:0008134)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Interferon-activable protein 204

Genular Protein ID: 105389985

Symbol: IFI4_MOUSE

Name: Interferon-activable protein 204

UniProtKB Accession Codes:

P0DOV2 B7ZNS3 P15092 Q08619 Q3TM07 Q3U776 Q3U7F4 Q3U7K5 Q3UCH9 Q8C4X3 Q921V9

Database IDs:

Citations:

PubMed ID: 2477366

Title: Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1.

PubMed ID: 2477366

DOI: 10.1016/s0021-9258(18)71476-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10329630

Title: The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription.

PubMed ID: 10329630

DOI: 10.1093/emboj/18.10.2845

PubMed ID: 11940648

Title: The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.

PubMed ID: 11940648

DOI: 10.1128/mcb.22.9.2893-2905.2002

PubMed ID: 15557274

Title: The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.

PubMed ID: 15557274

DOI: 10.1074/jbc.m412604200

PubMed ID: 16458891

Title: p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.

PubMed ID: 16458891

DOI: 10.1016/j.febslet.2006.01.032

PubMed ID: 16556595

Title: p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.

PubMed ID: 16556595

DOI: 10.1074/jbc.m511747200

PubMed ID: 16556596

Title: p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.

PubMed ID: 16556596

DOI: 10.1074/jbc.m511748200

PubMed ID: 16244109

Title: The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells.

PubMed ID: 16244109

DOI: 10.1189/jlb.0205083

PubMed ID: 25710914

Title: cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.

PubMed ID: 25710914

DOI: 10.4049/jimmunol.1402764

PubMed ID: 28529930

Title: The Central Role of IFI204 in IFN-beta Release and Autophagy Activation during Mycobacterium bovis Infection.

PubMed ID: 28529930

DOI: 10.3389/fcimb.2017.00169

PubMed ID: 30936875

Title: DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.

PubMed ID: 30936875

DOI: 10.3389/fimmu.2019.00474

PubMed ID: 33619523

Title: Structural mechanism of DNA recognition by the p204 HIN domain.

PubMed ID: 33619523

DOI: 10.1093/nar/gkab076

Sequence Information:

Length: 619
Mass: 69438
Checksum: 877717943E654308
Sequence:

MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN MMEEKFPADS 
GLGKLIAFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ EAGPATPTST TSHMLASERG 
ETSATQEETS TAQAGTSTAQ ARTSTAQAGT STAQKRKIMR EEETGVKKSK AAKEPDQPPC 
CEEPTARCQS PILHSSSSAS SNIPSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF 
EYESPEHEVK NMLHATVATV SQYFHVKVFN INLKEKFTKK NFIIISNYFE SKGILEINET 
SSVLEAAPDQ MIEVPNSIIR NANASPKICD IQKGTSGAVF YGVFTLHKKT VNRKNTIYEI 
KDGSGSIEVV GSGKWHNINC KEGDKLHLFC FHLKTIDRQP KLVCGEHSFI KISKRGNVPK 
EPAKEEDHHH GPKQVMVLKV TEPFTYDLKE DKRMFHATVA TETEFFRVKV FDTALKSKFI 
PRNIIAISDY FGCNGFLEIY RASCVSDVNV NPTMVISNTL RQRANATPKI SYLFSQARGT 
FVSGEYLVNK KTERNKFIYY GIGDDTGKME VVVYGRLTNV RCEPGSKLRL VCFELTSTED 
GWQLRSVRHS YMQVINARK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ifi204

Associated with

Other Information

Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. PubMed ID: 2477366

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. PubMed ID: 10329630

The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins. PubMed ID: 11940648

The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. PubMed ID: 15557274

p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. PubMed ID: 16458891

p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins. PubMed ID: 16556595

p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins. PubMed ID: 16556596

The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells. PubMed ID: 16244109

cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. PubMed ID: 25710914

The Central Role of IFI204 in IFN-beta Release and Autophagy Activation during Mycobacterium bovis Infection. PubMed ID: 28529930

DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice. PubMed ID: 30936875

Structural mechanism of DNA recognition by the p204 HIN domain. PubMed ID: 33619523