Genular: Defining Cellular Identity and Function

Details for: Ifnar1

Gene ID: 15975

Symbol: Ifnar1

Ensembl ID: ENSMUSG00000022967

Description: interferon (alpha and beta) receptor 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon signaling
(R-MMU-913531)
Regulation of ifna/ifnb signaling
(R-MMU-912694)
Cellular response to interferon-alpha
(GO:0035457)
Cellular response to interferon-beta
(GO:0035458)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Defense response to virus
(GO:0051607)
Endosome
(GO:0005768)
Gene expression
(GO:0010467)
Interferon receptor activity
(GO:0004904)
Jak pathway signal transduction adaptor activity
(GO:0008269)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Phosphoribosylamine-glycine ligase activity
(GO:0004637)
Plasma membrane
(GO:0005886)
Positive regulation of cellular respiration
(GO:1901857)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of type ii interferon production
(GO:0032729)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Response to lipopolysaccharide
(GO:0032496)
T cell activation
(GO:0042110)
Type ii interferon production
(GO:0032609)
Type i interferon-mediated signaling pathway
(GO:0060337)
Type i interferon binding
(GO:0019962)
Type i interferon production
(GO:0032606)
Type i interferon receptor activity
(GO:0004905)

Other Information

Proteins

Interferon alpha/beta receptor 1

Genular Protein ID: 3455740964

Symbol: INAR1_MOUSE

Name: Interferon alpha/beta receptor 1

UniProtKB Accession Codes:

P33896 Q80UJ3

Database IDs:

Citations:

PubMed ID: 1533935

Title: Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background.

PubMed ID: 1533935

DOI: 10.1073/pnas.89.10.4774

PubMed ID: 7958966

Title: Structure of the murine interferon alpha/beta receptor-encoding gene: high-frequency rearrangements in the interferon-resistant L1210 cell line.

PubMed ID: 7958966

DOI: 10.1016/0378-1119(94)90710-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14532120

Title: SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.

PubMed ID: 14532120

DOI: 10.1093/emboj/cdg524

PubMed ID: 18724932

Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.

PubMed ID: 18724932

DOI: 10.1016/j.cell.2008.06.032

PubMed ID: 24075985

Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

PubMed ID: 24075985

DOI: 10.1016/j.celrep.2013.08.025

PubMed ID: 23872679

Title: Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1.

PubMed ID: 23872679

DOI: 10.1038/ni.2667

Sequence Information:

Length: 590
Mass: 65796
Checksum: E887ADFA6DFEAF3C
Sequence:

MLAVVGAAAL VLVAGAPWVL PSAAGGENLK PPENIDVYII DDNYTLKWSS HGESMGSVTF 
SAEYRTKDEA KWLKVPECQH TTTTKCEFSL LDTNVYIKTQ FRVRAEEGNS TSSWNEVDPF 
IPFYTAHMSP PEVRLEAEDK AILVHISPPG QDGNMWALEK PSFSYTIRIW QKSSSDKKTI 
NSTYYVEKIP ELLPETTYCL EVKAIHPSLK KHSNYSTVQC ISTTVANKMP VPGNLQVDAQ 
GKSYVLKWDY IASADVLFRA QWLPGYSKSS SGSRSDKWKP IPTCANVQTT HCVFSQDTVY 
TGTFFLHVQA SEGNHTSFWS EEKFIDSQKH ILPPPPVITV TAMSDTLLVY VNCQDSTCDG 
LNYEIIFWEN TSNTKISMEK DGPEFTLKNL QPLTVYCVQA RVLFRALLNK TSNFSEKLCE 
KTRPGSFSTI WIITGLGVVF FSVMVLYALR SVWKYLCHVC FPPLKPPRSI DEFFSEPPSK 
NLVLLTAEEH TERCFIIENT DTVAVEVKHA PEEDLRKYSS QTSQDSGNYS NEEEESVGTE 
SGQAVLSKAP CGGPCSVPSP PGTLEDGTCF LGNEKYLQSP ALRTEPALLC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ifnar1

Associated with

Other Information

Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background. PubMed ID: 1533935

Structure of the murine interferon alpha/beta receptor-encoding gene: high-frequency rearrangements in the interferon-resistant L1210 cell line. PubMed ID: 7958966

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. PubMed ID: 14532120

Trex1 prevents cell-intrinsic initiation of autoimmunity. PubMed ID: 18724932

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. PubMed ID: 24075985

Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. PubMed ID: 23872679