Details for: Ifnb1

Gene ID: 15977

Symbol: Ifnb1

Ensembl ID: ENSMUSG00000048806

Description: interferon beta 1, fibroblast

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interferon alpha/beta signaling
    (R-MMU-909733)
  • Interferon signaling
    (R-MMU-913531)
  • Regulation of ifna/ifnb signaling
    (R-MMU-912694)
  • Adaptive immune response
    (GO:0002250)
  • B cell activation involved in immune response
    (GO:0002312)
  • B cell differentiation
    (GO:0030183)
  • B cell proliferation
    (GO:0042100)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cellular response to dsrna
    (GO:0071359)
  • Cellular response to interferon-beta
    (GO:0035458)
  • Cellular response to virus
    (GO:0098586)
  • Chloramphenicol o-acetyltransferase activity
    (GO:0008811)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor binding
    (GO:0005126)
  • Defense response
    (GO:0006952)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to virus
    (GO:0051607)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Humoral immune response
    (GO:0006959)
  • Innate immune response
    (GO:0045087)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood-brain barrier permeability
    (GO:1905604)
  • Negative regulation of cell adhesion molecule production
    (GO:0060354)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of immunoglobulin production
    (GO:0002638)
  • Negative regulation of lewy body formation
    (GO:0140123)
  • Negative regulation of matrix metallopeptidase secretion
    (GO:1904465)
  • Negative regulation of mononuclear cell migration
    (GO:0071676)
  • Negative regulation of neuroinflammatory response
    (GO:0150079)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of t-helper 2 cell cytokine production
    (GO:2000552)
  • Negative regulation of t cell differentiation
    (GO:0045581)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of viral genome replication
    (GO:0045071)
  • Neuron cellular homeostasis
    (GO:0070050)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of peptidyl-serine phosphorylation of stat protein
    (GO:0033141)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Response to exogenous dsrna
    (GO:0043330)
  • T cell activation involved in immune response
    (GO:0002286)
  • Type i interferon-mediated signaling pathway
    (GO:0060337)
  • Type i interferon receptor binding
    (GO:0005132)

Other Information

Genular Protein ID: 3256940410

Symbol: IFNB_MOUSE

Name: N/A

UniProtKB Accession Codes:

P01575

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 6688252

Title: Structure and expression of a cloned cDNA for mouse interferon-beta.

PubMed ID: 6688252

DOI: 10.1016/s0021-9258(17)44698-9

PubMed ID: 2726460

Title: Nucleotide sequence of the mouse interferon-beta gene.

PubMed ID: 2726460

DOI: 10.1093/nar/17.8.3291

PubMed ID: 3221389

Title: Structure and characterization of a murine chromosomal fragment containing the interferon beta gene.

PubMed ID: 3221389

DOI: 10.1016/0022-2836(88)90571-2

PubMed ID: 3360010

Title: Purification and carbohydrate structure of natural murine interferon-beta.

PubMed ID: 3360010

DOI: 10.1111/j.1432-1033.1988.tb14000.x

PubMed ID: 1505514

Title: Three-dimensional crystal structure of recombinant murine interferon-beta.

PubMed ID: 1505514

DOI: 10.1002/j.1460-2075.1992.tb05396.x

PubMed ID: 10708458

Title: Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.

PubMed ID: 10708458

DOI: 10.1128/jvi.74.7.3404-3409.2000

PubMed ID: 12707359

Title: IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

PubMed ID: 12707359

DOI: 10.4049/jimmunol.170.9.4776

PubMed ID: 14597717

Title: Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha.

PubMed ID: 14597717

DOI: 10.1073/pnas.2230460100

PubMed ID: 26451483

Title: Lack of neuronal IFN-beta-IFNAR causes Lewy body- and Parkinson's disease-like dementia.

PubMed ID: 26451483

DOI: 10.1016/j.cell.2015.08.069

PubMed ID: 7473712

Title: Refined crystal structure of recombinant murine interferon-beta at 2.15-A resolution.

PubMed ID: 7473712

DOI: 10.1006/jmbi.1995.0544

PubMed ID: 23872679

Title: Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1.

PubMed ID: 23872679

DOI: 10.1038/ni.2667

Sequence Information:

  • Length: 182
  • Mass: 22127
  • Checksum: 8C4C32947FD1B917
  • Sequence:
    • MNNRWILHAA FLLCFSTTAL SINYKQLQLQ ERTNIRKCQE LLEQLNGKIN LTYRADFKIP 
MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI VVRLLDELHQ QTVFLKTVLE 
EKQEERLTWE MSSTALHLKS YYWRVQRYLK LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF 
QN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.