Details for: Ifng

Gene ID: 15978

Symbol: Ifng

Ensembl ID: ENSMUSG00000055170

Description: interferon gamma

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Ifng signaling activates mapks
    (R-MMU-9732724)
  • Immune system
    (R-MMU-168256)
  • Interferon gamma signaling
    (R-MMU-877300)
  • Interferon signaling
    (R-MMU-913531)
  • Regulation of ifng signaling
    (R-MMU-877312)
  • Adaptive immune response
    (GO:0002250)
  • Antigen processing and presentation
    (GO:0019882)
  • Apoptotic process
    (GO:0006915)
  • Astrocyte activation
    (GO:0048143)
  • Cd8-positive, alpha-beta t cell differentiation involved in immune response
    (GO:0002302)
  • Cytokine activity
    (GO:0005125)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Defense response to protozoan
    (GO:0042832)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Humoral immune response
    (GO:0006959)
  • Immune response
    (GO:0006955)
  • Inflammatory cell apoptotic process
    (GO:0006925)
  • Interleukin-12 production
    (GO:0032615)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Macrophage cytokine production
    (GO:0010934)
  • Macrophage differentiation
    (GO:0030225)
  • Microglial cell activation
    (GO:0001774)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell differentiation
    (GO:0030857)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of myelination
    (GO:0031642)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neutrophil apoptotic process
    (GO:0001781)
  • Neutrophil chemotaxis
    (GO:0030593)
  • Nitric oxide biosynthetic process
    (GO:0006809)
  • Positive regulation by host of viral process
    (GO:0044794)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation involved in immune response
    (GO:0032834)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell migration
    (GO:0010634)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of isotype switching to igg isotypes
    (GO:0048304)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of peptidyl-serine phosphorylation of stat protein
    (GO:0033141)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of synaptic transmission, cholinergic
    (GO:0032224)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein binding
    (GO:0005515)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Regulation of defense response to virus by host
    (GO:0050691)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of immune response
    (GO:0050776)
  • Regulation of insulin secretion
    (GO:0050796)
  • Regulation of the force of heart contraction
    (GO:0002026)
  • Response to virus
    (GO:0009615)
  • T cell proliferation
    (GO:0042098)
  • Type iii interferon-mediated signaling pathway
    (GO:0038196)
  • Type ii interferon receptor binding
    (GO:0005133)

Other Information

Genular Protein ID: 2288878715

Symbol: IFNG_MOUSE

Name: Interferon gamma

UniProtKB Accession Codes:

P01580 Q542B8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 4 EPD 1 Ensembl 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 6310596

Title: Cloning and expression of murine immune interferon cDNA.

PubMed ID: 6310596

DOI: 10.1073/pnas.80.19.5842

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8456301

Title: Immune response in mice that lack the interferon-gamma receptor.

PubMed ID: 8456301

DOI: 10.1126/science.8456301

PubMed ID: 11585387

Title: Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.

PubMed ID: 11585387

DOI: 10.1006/cimm.2001.1819

PubMed ID: 20535209

Title: Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.

PubMed ID: 20535209

DOI: 10.1038/nature09135

PubMed ID: 25078851

Title: Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells.

PubMed ID: 25078851

DOI: 10.1002/stem.1799

Sequence Information:

  • Length: 155
  • Mass: 17907
  • Checksum: 7EE80BAECB42071A
  • Sequence:
    • MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF LDIWRNWQKD 
GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT TFFSNSKAKK DAFMSIAKFE 
VNNPQVQRQA FNELIRVVHQ LLPESSLRKR KRSRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.