Genular: Defining Cellular Identity and Function

Details for: Cd79b

Gene ID: 15985

Symbol: Cd79b

Ensembl ID: ENSMUSG00000040592

Description: CD79B antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Cd22 mediated bcr regulation
(R-MMU-5690714)
Immune system
(R-MMU-168256)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Adaptive immune response
(GO:0002250)
B cell differentiation
(GO:0030183)
B cell receptor complex
(GO:0019815)
B cell receptor signaling pathway
(GO:0050853)
Cell surface receptor signaling pathway
(GO:0007166)
External side of plasma membrane
(GO:0009897)
Identical protein binding
(GO:0042802)
Igm b cell receptor complex
(GO:0071755)
Immune system process
(GO:0002376)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Response to bacterium
(GO:0009617)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

B-cell antigen receptor complex-associated protein beta chain

Genular Protein ID: 2789077112

Symbol: CD79B_MOUSE

Name: B-cell antigen receptor complex-associated protein beta chain

UniProtKB Accession Codes:

P15530 Q4FJP4

Database IDs:

Citations:

PubMed ID: 3137575

Title: B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

PubMed ID: 3137575

DOI: 10.1073/pnas.85.18.6890

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2508087

Title: Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.

PubMed ID: 2508087

DOI: 10.1073/pnas.86.19.7341

PubMed ID: 1506682

Title: The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.

PubMed ID: 1506682

PubMed ID: 15335855

Title: B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.

PubMed ID: 15335855

DOI: 10.1016/0960-9822(93)90062-s

PubMed ID: 8175787

Title: Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta.

PubMed ID: 8175787

DOI: 10.1016/s0021-9258(17)36863-1

PubMed ID: 7592958

Title: Reconstitution of the B cell antigen receptor signaling components in COS cells.

PubMed ID: 7592958

DOI: 10.1074/jbc.270.45.27072

PubMed ID: 8976175

Title: The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors.

PubMed ID: 8976175

DOI: 10.1084/jem.184.6.2197

PubMed ID: 10587346

Title: A role for lipid rafts in B cell antigen receptor signaling and antigen targeting.

PubMed ID: 10587346

DOI: 10.1084/jem.190.11.1549

PubMed ID: 10352267

Title: Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation.

PubMed ID: 10352267

PubMed ID: 11238609

Title: Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling.

PubMed ID: 11238609

DOI: 10.4049/jimmunol.166.6.3693

PubMed ID: 12356683

Title: Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting.

PubMed ID: 12356683

DOI: 10.1093/intimm/dxf083

PubMed ID: 15661879

Title: Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization.

PubMed ID: 15661879

DOI: 10.4049/jimmunol.174.3.1245

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20696394

Title: Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.

PubMed ID: 20696394

DOI: 10.1016/j.str.2010.04.019

Sequence Information:

Length: 228
Mass: 25726
Checksum: 9A3A2008648E8307
Sequence:

MATLVLSSMP CHWLLFLLLL FSGEPVPAMT SSDLPLNFQG SPCSQIWQHP RFAAKKRSSM 
VKFHCYTNHS GALTWFRKRG SQQPQELVSE EGRIVQTQNG SVYTLTIQNI QYEDNGIYFC 
KQKCDSANHN VTDSCGTELL VLGFSTLDQL KRRNTLKDGI ILIQTLLIIL FIIVPIFLLL 
DKDDGKAGME EDHTYEGLNI DQTATYEDIV TLRTGEVKWS VGEHPGQE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd79b

Associated with

Other Information

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. PubMed ID: 3137575

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene. PubMed ID: 2508087

The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. PubMed ID: 1506682

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. PubMed ID: 15335855

Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta. PubMed ID: 8175787

Reconstitution of the B cell antigen receptor signaling components in COS cells. PubMed ID: 7592958

The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors. PubMed ID: 8976175

A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. PubMed ID: 10587346

Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation. PubMed ID: 10352267

Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. PubMed ID: 11238609

Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting. PubMed ID: 12356683

Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization. PubMed ID: 15661879

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. PubMed ID: 20696394