Gene AP2A1 - ENSG00000196961 | NCBI Gene ID: 160

Details for: AP2A1

Gene ID: 160

Symbol: AP2A1

Ensembl ID: ENSG00000196961

Description: adaptor related protein complex 2 subunit alpha 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
L1cam interactions
(R-HSA-373760)
Ldl clearance
(R-HSA-8964038)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Nef mediated cd8 down-regulation
(R-HSA-182218)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Pcp/ce pathway
(R-HSA-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Potential therapeutics for sars
(R-HSA-9679191)
Recycling pathway of l1
(R-HSA-437239)
Retrograde neurotrophin signalling
(R-HSA-177504)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Vldlr internalisation and degradation
(R-HSA-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-HSA-5140745)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Ap-2 adaptor complex
(GO:0030122)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Clathrin coat of trans-golgi network vesicle
(GO:0030130)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Endocytosis
(GO:0006897)
Endolysosome membrane
(GO:0036020)
Filopodium tip
(GO:0032433)
Golgi to endosome transport
(GO:0006895)
Intracellular protein transport
(GO:0006886)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Negative regulation of hyaluronan biosynthetic process
(GO:1900126)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Postsynapse
(GO:0098794)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Vesicle-mediated transport
(GO:0016192)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: Leydig cell (CL0000178)
Fold Change: 1.82
Marker Score: 1956.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.53
Marker Score: 6022
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.41
Marker Score: 15930
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.33
Marker Score: 2706
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.33
Marker Score: 13705
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.32
Marker Score: 48646.5
Cell Name: decidual cell (CL2000002)
Fold Change: 1.29
Marker Score: 5583
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.29
Marker Score: 878
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.29
Marker Score: 7657.5
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.29
Marker Score: 2515
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.29
Marker Score: 1992
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.26
Marker Score: 8227
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.26
Marker Score: 1410
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.24
Marker Score: 10687
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.23
Marker Score: 75769
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.21
Marker Score: 3002
Cell Name: male germ cell (CL0000015)
Fold Change: 1.2
Marker Score: 347
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.2
Marker Score: 1720
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.18
Marker Score: 1087
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.18
Marker Score: 2775
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.16
Marker Score: 2450
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.15
Marker Score: 11603.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.15
Marker Score: 10926
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.15
Marker Score: 1436
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.13
Marker Score: 849.5
Cell Name: neuron (CL0000540)
Fold Change: 1.13
Marker Score: 4587
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.12
Marker Score: 4627
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1
Marker Score: 17247
Cell Name: neural cell (CL0002319)
Fold Change: 1.09
Marker Score: 526
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.09
Marker Score: 2960
Cell Name: oocyte (CL0000023)
Fold Change: 1.08
Marker Score: 267
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.08
Marker Score: 10131
Cell Name: Unknown (CL0002371)
Fold Change: 1.06
Marker Score: 1131
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.06
Marker Score: 1218
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.05
Marker Score: 2526
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.04
Marker Score: 327
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.04
Marker Score: 35431
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.03
Marker Score: 332
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.01
Marker Score: 3757
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.01
Marker Score: 56524
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.01
Marker Score: 1214
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71662
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47886
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30380
Cell Name: keratocyte (CL0002363)
Fold Change: 0.98
Marker Score: 225
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.97
Marker Score: 1173
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.96
Marker Score: 1416
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.96
Marker Score: 606
Cell Name: erythroblast (CL0000765)
Fold Change: 0.95
Marker Score: 595
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.94
Marker Score: 233
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.94
Marker Score: 329
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.94
Marker Score: 888
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.94
Marker Score: 18721.5
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.94
Marker Score: 3638
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2387
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.93
Marker Score: 312.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.93
Marker Score: 13874
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.92
Marker Score: 1424
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.91
Marker Score: 471
Cell Name: Unknown (CL0000548)
Fold Change: 0.91
Marker Score: 665.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 430
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.91
Marker Score: 34389
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.9
Marker Score: 438.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9
Marker Score: 1827
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2688
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.9
Marker Score: 843.5
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.89
Marker Score: 374
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.88
Marker Score: 381
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.88
Marker Score: 304.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.88
Marker Score: 600
Cell Name: blood cell (CL0000081)
Fold Change: 0.88
Marker Score: 10197
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.87
Marker Score: 717
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.87
Marker Score: 1818
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.86
Marker Score: 2384
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.86
Marker Score: 1466
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.86
Marker Score: 372
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.85
Marker Score: 2007.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.84
Marker Score: 5038
Cell Name: acinar cell (CL0000622)
Fold Change: 0.84
Marker Score: 590
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.83
Marker Score: 17729.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.83
Marker Score: 1347
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.83
Marker Score: 4717
Cell Name: podocyte (CL0000653)
Fold Change: 0.82
Marker Score: 304
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.82
Marker Score: 335
Cell Name: plasmablast (CL0000980)
Fold Change: 0.82
Marker Score: 1090.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.81
Marker Score: 489
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.81
Marker Score: 1334
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.81
Marker Score: 6041
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.81
Marker Score: 7044
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.81
Marker Score: 857
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 616.5
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.8
Marker Score: 2104
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 321
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.8
Marker Score: 6137
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.8
Marker Score: 840
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.79
Marker Score: 1523
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.79
Marker Score: 525
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.79
Marker Score: 871

Hover over a box to see details here...

**Key characteristics:** * AP2A1 is a transmembrane protein that is expressed on the surface of immune cells. * It is a glycoprotein that is composed of two extracellular immunoglobulin heavy chains and two extracellular immunoglobulin light chains. * AP2A1 is a member of the AP2 family of cell adhesion molecules, which are expressed in a variety of cell types. * It is involved in the regulation of T cell activation and differentiation. **Pathways and functions:** * AP2A1 is involved in the regulation of T cell activation and differentiation. * It is expressed on the surface of T cells, and its expression is upregulated during activation. * AP2A1 binds to the integrin beta-1 receptor, which is expressed on activated T cells. * This binding event recruits AP2A1 to the T cell surface, where it is able to interact with its target molecule, CD28. * This interaction between AP2A1 and CD28 is essential for the activation of T cells. **Clinical significance:** AP2A1 is a promising target for the treatment of cancer. Studies have shown that AP2A1 inhibitors can inhibit T cell activation and prevent the growth of cancer cells. This makes AP2A1 a potential therapeutic target for the treatment of cancer. **Additional notes:** * AP2A1 is a highly conserved protein, and it is found in organisms from mice to humans. * It is expressed in high levels in tissues that are involved in immune function, such as the thymus, lymph nodes, and spleen. * Mutations in the AP2A1 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis and lupus.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AP-2 complex subunit alpha-1

Genular Protein ID: 628385147

Symbol: AP2A1_HUMAN

Name: AP-2 complex subunit alpha-1

UniProtKB Accession Codes:

O95782 Q96CI7 Q96PP6 Q96PP7 Q9H070

Database IDs:

Citations:

PubMed ID: 12036598

Title: Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.

PubMed ID: 12036598

DOI: 10.1016/s0378-1119(02)00504-8

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 12364336

Title: Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.

PubMed ID: 12364336

DOI: 10.1074/jbc.m206316200

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 16262731

Title: Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.

PubMed ID: 16262731

DOI: 10.1111/j.1600-0854.2005.00355.x

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22262466

Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

PubMed ID: 22262466

DOI: 10.1002/hep.25591

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27022195

Title: Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.

PubMed ID: 27022195

DOI: 10.4049/jimmunol.1501734

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

Sequence Information:

Length: 977
Mass: 107546
Checksum: D9FB569E7EDDF6ED
Sequence:

MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC 
KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL 
ASRNPTFMCL ALHCIANVGS REMGEAFAAD IPRILVAGDS MDSVKQSAAL CLLRLYKASP 
DLVPMGEWTA RVVHLLNDQH MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA 
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL ESMCTLASSE 
FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS NAKQIVSEML RYLETADYAI 
REEIVLKVAI LAEKYAVDYS WYVDTILNLI RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA 
KTVFEALQAP ACHENMVKVG GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL 
LLSTYIKFIN LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST VSTPSPSADL 
LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE EAFLSELEPP APESPMALLA 
DPAPAADPGP EDIGPPIPEA DELLNKFVCK NNGVLFENQL LQIGVKSEFR QNLGRMYLFY 
GNKTSVQFQN FSPTVVHPGD LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL 
SVRFRYGGAP QALTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPQQEAQ KIFKANHPMD 
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ AQMYRLTLRT 
SKEPVSRHLC ELLAQQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AP2A1

Associated with

Cells (max top 100)

Other Information

Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. PubMed ID: 12036598

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. PubMed ID: 11532990

Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. PubMed ID: 12364336

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. PubMed ID: 14745134

Adaptors for clathrin coats: structure and function. PubMed ID: 15473838

Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. PubMed ID: 16262731

The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. PubMed ID: 19033387

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. PubMed ID: 22262466

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner. PubMed ID: 27022195

APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development. PubMed ID: 29262337