AP2A1 | ENSG00000196961 | NCBI 160

Details for: AP2A1

Gene ID: 160

Symbol: AP2A1

Ensembl ID: ENSG00000196961

Description: adaptor related protein complex 2 subunit alpha 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
L1cam interactions
(R-HSA-373760)
Ldl clearance
(R-HSA-8964038)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Nef mediated cd8 down-regulation
(R-HSA-182218)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Pcp/ce pathway
(R-HSA-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Potential therapeutics for sars
(R-HSA-9679191)
Recycling pathway of l1
(R-HSA-437239)
Retrograde neurotrophin signalling
(R-HSA-177504)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Vldlr internalisation and degradation
(R-HSA-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-HSA-5140745)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Ap-2 adaptor complex
(GO:0030122)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Clathrin coat of trans-golgi network vesicle
(GO:0030130)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Endocytosis
(GO:0006897)
Endolysosome membrane
(GO:0036020)
Filopodium tip
(GO:0032433)
Golgi to endosome transport
(GO:0006895)
Intracellular protein transport
(GO:0006886)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Negative regulation of hyaluronan biosynthetic process
(GO:1900126)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Postsynapse
(GO:0098794)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

AP-2 complex subunit alpha-1

Genular Protein ID: 628385147

Symbol: AP2A1_HUMAN

Name: AP-2 complex subunit alpha-1

UniProtKB Accession Codes:

O95782 Q96CI7 Q96PP6 Q96PP7 Q9H070

Database IDs:

Citations:

PubMed ID: 12036598

Title: Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.

PubMed ID: 12036598

DOI: 10.1016/s0378-1119(02)00504-8

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 12364336

Title: Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.

PubMed ID: 12364336

DOI: 10.1074/jbc.m206316200

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 16262731

Title: Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.

PubMed ID: 16262731

DOI: 10.1111/j.1600-0854.2005.00355.x

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22262466

Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

PubMed ID: 22262466

DOI: 10.1002/hep.25591

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27022195

Title: Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.

PubMed ID: 27022195

DOI: 10.4049/jimmunol.1501734

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

Sequence Information:

Length: 977
Mass: 107546
Checksum: D9FB569E7EDDF6ED
Sequence:

MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC 
KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL 
ASRNPTFMCL ALHCIANVGS REMGEAFAAD IPRILVAGDS MDSVKQSAAL CLLRLYKASP 
DLVPMGEWTA RVVHLLNDQH MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA 
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL ESMCTLASSE 
FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS NAKQIVSEML RYLETADYAI 
REEIVLKVAI LAEKYAVDYS WYVDTILNLI RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA 
KTVFEALQAP ACHENMVKVG GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL 
LLSTYIKFIN LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST VSTPSPSADL 
LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE EAFLSELEPP APESPMALLA 
DPAPAADPGP EDIGPPIPEA DELLNKFVCK NNGVLFENQL LQIGVKSEFR QNLGRMYLFY 
GNKTSVQFQN FSPTVVHPGD LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL 
SVRFRYGGAP QALTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPQQEAQ KIFKANHPMD 
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ AQMYRLTLRT 
SKEPVSRHLC ELLAQQF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AP2A1

Associated with

Other Information

Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. PubMed ID: 12036598

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. PubMed ID: 11532990

Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. PubMed ID: 12364336

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. PubMed ID: 14745134

Adaptors for clathrin coats: structure and function. PubMed ID: 15473838

Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. PubMed ID: 16262731

The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. PubMed ID: 19033387

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. PubMed ID: 22262466

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner. PubMed ID: 27022195

APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development. PubMed ID: 29262337