Details for: Igf1

Gene ID: 16000

Symbol: Igf1

Ensembl ID: ENSMUSG00000020053

Description: insulin-like growth factor 1

Associated with

  • Hemostasis
    (R-MMU-109582)
  • Igf1r signaling cascade
    (R-MMU-2428924)
  • Irs-related events triggered by igf1r
    (R-MMU-2428928)
  • Metabolism of proteins
    (R-MMU-392499)
  • Peptide hormone metabolism
    (R-MMU-2980736)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-MMU-381426)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Shc-related events triggered by igf1r
    (R-MMU-2428933)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
    (R-MMU-2404192)
  • Signal transduction
    (R-MMU-162582)
  • Synthesis, secretion, and deacylation of ghrelin
    (R-MMU-422085)
  • Activation of protein kinase b activity
    (GO:0032148)
  • Androgen receptor signaling pathway
    (GO:0030521)
  • Blood vessel remodeling
    (GO:0001974)
  • Bone mineralization involved in bone maturation
    (GO:0035630)
  • Cell activation
    (GO:0001775)
  • Cell population proliferation
    (GO:0008283)
  • Cerebellar granule cell precursor proliferation
    (GO:0021930)
  • Circadian rhythm
    (GO:0007623)
  • Exocrine pancreas development
    (GO:0031017)
  • Glial cell differentiation
    (GO:0010001)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin receptor binding
    (GO:0005158)
  • Integrin binding
    (GO:0005178)
  • Lung development
    (GO:0030324)
  • Mammary gland development
    (GO:0030879)
  • Memory
    (GO:0007613)
  • Multicellular organism growth
    (GO:0035264)
  • Muscle hypertrophy
    (GO:0014896)
  • Myoblast differentiation
    (GO:0045445)
  • Myotube cell development
    (GO:0014904)
  • Myotube differentiation
    (GO:0014902)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of immune system process
    (GO:0002683)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of muscle cell apoptotic process
    (GO:0010656)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nervous system development
    (GO:0007399)
  • Osteoblast differentiation
    (GO:0001649)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cerebellar granule cell precursor proliferation
    (GO:0021940)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna binding
    (GO:0043388)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of glycoprotein biosynthetic process
    (GO:0010560)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of myelination
    (GO:0031643)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Proteoglycan biosynthetic process
    (GO:0030166)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of establishment or maintenance of cell polarity
    (GO:0032878)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of intracellular steroid hormone receptor signaling pathway
    (GO:0033143)
  • Regulation of nitric oxide biosynthetic process
    (GO:0045428)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Regulation of translation
    (GO:0006417)
  • Response to ethanol
    (GO:0045471)
  • Response to heat
    (GO:0009408)
  • Sensory perception of smell
    (GO:0007608)
  • Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
    (GO:0014834)
  • Steroid binding
    (GO:0005496)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)
  • Type b pancreatic cell proliferation
    (GO:0044342)
  • Wound healing
    (GO:0042060)

Other Information

Genular Protein ID: 3310803282

Symbol: IGF1_MOUSE

Name: Insulin-like growth factor I

UniProtKB Accession Codes:

P05017 P05018 Q6LDP4 Q8C4U6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3774549

Title: Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors.

PubMed ID: 3774549

DOI: 10.1093/nar/14.20.7873

PubMed ID: 2474537

Title: Insulin-like growth factors (IGF) in muscle development. Expression of IGF-I, the IGF-I receptor, and an IGF binding protein during myoblast differentiation.

PubMed ID: 2474537

DOI: 10.1016/s0021-9258(18)80073-4

PubMed ID: 3467309

Title: Regulation of insulin-like growth factor I gene expression by growth hormone.

PubMed ID: 3467309

DOI: 10.1073/pnas.83.24.9343

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20685873

Title: Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.

PubMed ID: 20685873

DOI: 10.1210/en.2010-0407

PubMed ID: 20881139

Title: The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.

PubMed ID: 20881139

DOI: 10.1523/jneurosci.3289-10.2010

PubMed ID: 21496647

Title: Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.

PubMed ID: 21496647

DOI: 10.1016/j.cell.2011.03.034

Sequence Information:

  • Length: 153
  • Mass: 17093
  • Checksum: 967596AEAC0CA387
  • Sequence:
    • MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSTTAGP ETLCGAELVD 
ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPTKAARS 
IRAQRHTDMP KTQKEVHLKN TSRGSAGNKT YRM

Genular Protein ID: 715610975

Symbol: Q4VJB9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q4VJB9

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16099410

Title: Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

PubMed ID: 16099410

DOI: 10.1016/j.ymthe.2005.04.001

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 159
  • Mass: 17888
  • Checksum: 8699553C6311A323
  • Sequence:
    • MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSTTAGP ETLCGAELVD 
ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPTKAARS 
IRAQRHTDMP KTQKSPSLST NKKTKLQRRR KGSTFEEHK

Genular Protein ID: 3141183303

Symbol: E9PU89_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PU89

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 Genevisible 1 InterPro 6 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 143
  • Mass: 15992
  • Checksum: E3242F4BA7C15440
  • Sequence:
    • MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC GPRGFYFNKP 
TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK AARSIRAQRH TDMPKTQKSP 
SLSTNKKTKL QRRRKGSTFE EHK

Genular Protein ID: 14420947

Symbol: Q8CAR0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CAR0

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 49 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SAM 2 SMART 2 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 165
  • Mass: 18473
  • Checksum: 2CE0D3DA981C93F8
  • Sequence:
    • MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC GPRGFYFNKP 
TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK AARSIRAQRH TDMPKTQKSP 
SLSTNKKTKL QRRRKGEPKT HPEGEQEEVT EATRKIRGPR EKRLG

Genular Protein ID: 3313480782

Symbol: E9Q138_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9Q138

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 137
  • Mass: 15197
  • Checksum: B116D99EF4BFB864
  • Sequence:
    • MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC GPRGFYFNKP 
TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK AARSIRAQRH TDMPKTQKEV 
HLKNTSRGSA GNKTYRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.