Details for: Igf2

Gene ID: 16002

Symbol: Igf2

Ensembl ID: ENSMUSG00000048583

Description: insulin-like growth factor 2

Associated with

  • Hemostasis
    (R-MMU-109582)
  • Igf1r signaling cascade
    (R-MMU-2428924)
  • Irs-related events triggered by igf1r
    (R-MMU-2428928)
  • Metabolism of proteins
    (R-MMU-392499)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-MMU-381426)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Shc-related events triggered by igf1r
    (R-MMU-2428933)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
    (R-MMU-2404192)
  • Signal transduction
    (R-MMU-162582)
  • Animal organ morphogenesis
    (GO:0009887)
  • Carbohydrate metabolic process
    (GO:0005975)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic placenta morphogenesis
    (GO:0060669)
  • Exocrine pancreas development
    (GO:0031017)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glucose metabolic process
    (GO:0006006)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Integrin binding
    (GO:0005178)
  • In utero embryonic development
    (GO:0001701)
  • Memory
    (GO:0007613)
  • Negative regulation of muscle cell differentiation
    (GO:0051148)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Ossification
    (GO:0001503)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of skeletal muscle tissue growth
    (GO:0048633)
  • Positive regulation of steroid hormone biosynthetic process
    (GO:0090031)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of muscle cell differentiation
    (GO:0051147)
  • Response to nicotine
    (GO:0035094)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Spongiotrophoblast cell proliferation
    (GO:0060720)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)

Other Information

Genular Protein ID: 569106929

Symbol: IGF2_MOUSE

Name: Insulin-like growth factor II

UniProtKB Accession Codes:

P09535 E9QLW5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 46 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3780370

Title: Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor.

PubMed ID: 3780370

DOI: 10.1089/dna.1986.5.357

PubMed ID: 1702294

Title: Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons.

PubMed ID: 1702294

DOI: 10.1089/dna.1990.9.725

PubMed ID: 9039503

Title: Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.

PubMed ID: 9039503

DOI: 10.1093/dnares/3.5.331

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2537977

Title: Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation.

PubMed ID: 2537977

DOI: 10.1073/pnas.86.5.1543

PubMed ID: 8265819

Title: Differential expression of the human, mouse and rat IGF-II genes.

PubMed ID: 8265819

DOI: 10.1016/0167-0115(93)90337-8

PubMed ID: 11716772

Title: Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion.

PubMed ID: 11716772

DOI: 10.1042/0264-6021:3600431

PubMed ID: 2330056

Title: A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

PubMed ID: 2330056

DOI: 10.1038/345078a0

PubMed ID: 1997210

Title: Parental imprinting of the mouse insulin-like growth factor II gene.

PubMed ID: 1997210

DOI: 10.1016/0092-8674(91)90513-x

PubMed ID: 12087403

Title: Placental-specific IGF-II is a major modulator of placental and fetal growth.

PubMed ID: 12087403

DOI: 10.1038/nature00819

PubMed ID: 16901893

Title: Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II.

PubMed ID: 16901893

DOI: 10.1074/jbc.m605445200

PubMed ID: 16912056

Title: Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.

PubMed ID: 16912056

DOI: 10.1152/ajpendo.00642.2005

PubMed ID: 19706595

Title: NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation.

PubMed ID: 19706595

DOI: 10.1074/jbc.m109.034041

PubMed ID: 24593700

Title: Insulin-like growth factor-II: its role in metabolic and endocrine disease.

PubMed ID: 24593700

DOI: 10.1111/cen.12446

PubMed ID: 28522536

Title: A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.

PubMed ID: 28522536

DOI: 10.1126/science.aah6895

PubMed ID: 29440408

Title: The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

PubMed ID: 29440408

DOI: 10.1073/pnas.1719278115

PubMed ID: 32557799

Title: The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells.

PubMed ID: 32557799

DOI: 10.1096/fj.201901321r

Sequence Information:

  • Length: 180
  • Mass: 20030
  • Checksum: 01730F8856EE6D7B
  • Sequence:
    • MGIPVGKSML VLLISLAFAL CCIAAYGPGE TLCGGELVDT LQFVCSDRGF YFSRPSSRAN 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTSQAV LPDDFPRYPV GKFFQYDTWR 
QSAGRLRRGL PALLRARRGR MLAKELKEFR EAKRHRPLIV LPPKDPAHGG ASSEMSSNHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.