Genular: Defining Cellular Identity and Function

Details for: Igf2r

Gene ID: 16004

Symbol: Igf2r

Ensembl ID: ENSMUSG00000023830

Description: insulin-like growth factor 2 receptor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Golgi associated vesicle biogenesis
(R-MMU-432722)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Membrane trafficking
(R-MMU-199991)
Neutrophil degranulation
(R-MMU-6798695)
Retrograde transport at the trans-golgi-network
(R-MMU-6811440)
Trans-golgi network vesicle budding
(R-MMU-199992)
Vesicle-mediated transport
(R-MMU-5653656)
Cell surface
(GO:0009986)
Clathrin coat
(GO:0030118)
Early endosome
(GO:0005769)
Endocytic vesicle
(GO:0030139)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Enzyme binding
(GO:0019899)
Extracellular space
(GO:0005615)
G-protein alpha-subunit binding
(GO:0001965)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Insulin-like growth factor binding
(GO:0005520)
Insulin-like growth factor ii binding
(GO:0031995)
Late endosome
(GO:0005770)
Liver development
(GO:0001889)
Lysosomal transport
(GO:0007041)
Mannose binding
(GO:0005537)
Membrane
(GO:0016020)
Nuclear envelope lumen
(GO:0005641)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphoprotein binding
(GO:0051219)
Plasma membrane
(GO:0005886)
Positive regulation by host of viral process
(GO:0044794)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Response to retinoic acid
(GO:0032526)
Retinoic acid binding
(GO:0001972)
Retromer complex binding
(GO:1905394)
Signaling receptor activity
(GO:0038023)
Trans-golgi network
(GO:0005802)
Trans-golgi network transport vesicle
(GO:0030140)

Other Information

Proteins

Cation-independent mannose-6-phosphate receptor
Q8C6V9_MOUSE

Genular Protein ID: 313626223

Symbol: MPRI_MOUSE

Name: Cation-independent mannose-6-phosphate receptor

UniProtKB Accession Codes:

Q07113 Q61822 Q6LED1

Database IDs:

Citations:

PubMed ID: 8188212

Title: The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization.

PubMed ID: 8188212

DOI: 10.1006/geno.1994.1021

PubMed ID: 8194771

Title: Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor.

PubMed ID: 8194771

DOI: 10.1016/0378-1119(94)90282-8

PubMed ID: 8462104

Title: Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.

PubMed ID: 8462104

DOI: 10.1016/0092-8674(93)90160-r

PubMed ID: 8584025

Title: Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements.

PubMed ID: 8584025

DOI: 10.1210/mend.9.11.8584025

PubMed ID: 1848553

Title: Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells.

PubMed ID: 1848553

DOI: 10.1016/s0021-9258(19)67627-1

PubMed ID: 8226743

Title: Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes.

PubMed ID: 8226743

DOI: 10.1016/s0021-9258(18)41533-5

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 2483
Mass: 273815
Checksum: 8F64F6189FD05CD1
Sequence:

MRAVQLGPVP SGPRVALLPP LLLLLLLAAA GSAQAQAVDL DALCSYTWEA VDSKNNAVYK 
INVCGNVGIS SCGPTSAICM CDLKTENCRS VGDSLLRSSA RSLLEFNTTM GCQPSDSQHR 
IQTSITFLCG KTLGTPEFVT ATDCVHYFEW RTTAACKKDI FKADKEVPCY AFDDKLQKHD 
LNPLIKLNGG YLVDDSDPDT SLFINVCRDI DSLRDPSTQL RVCPAGTAAC LLKGNQAFDV 
GRPKEGLKLL SKDRLVLTYV KEEGEKPDFC NGHSPAVTVT FVCPSERREG TIPKLTAKSN 
CRYEVEWITE YACHRDYLQS ESCSLSSEQH DITIDLSPLA QYGGSPYVSD GREYTFFINV 
CGDTKVSLCN NKEAAVCQEK KADSTQVKIA GRHQNQTLRY SDGDLTLIYS GGDECSSGFQ 
RMSVINFECN KTAGKDGRGE PVFTGEVDCT YFFTWDTKYA CIKEKEDLLC GAINGKKRYD 
LSVLARHSES EQNWEAVDGS QAESEKYFFI NVCHRVLQEG KARNCPEDAA VCAVDKNGSK 
NLGKFVSSPT KEKGHIQLSY TDGDDCGSDK KISTNITLVC KPGDLESAPV LRAARSDGCF 
YEFEWHTAAA CVLSKTEGEN CTVLDAQAGF SFDLSLLTKK NGAYKVETEK YDFYINVCGP 
VSMDPCQSNS GACQVAKSGK SWNLGLSSTK LTYYDGMIQL SYRNGTPYNN EKHTPRATLI 
TFLCDRDAGV GFPEYQEEDN STYNFRWYTS YACPEEPLEC MVTDPSMMEQ YDLSSLVKSE 
GGSGGNWYAM ENSREHVTRR KYYLNVCRPL NPVPGCDRYA SACQMKYENH EGSLAETVSI 
SNLGVAKIGP VVEESGSLLL EYVNGSACTT SDGQLTTYST RIHLVCGRGF MNSHPIFTFN 
WECVVSFLWN TEAACPIQTI TETDQACSIR DPSSGFVFNL SPLNDSAQGH VVLGIGKTFV 
FNICGAMPAC GTVAGKPAYG CEAETQIEDI KDLRPQRPVG MERSLQLSAE GFLTLTYKGS 
SPSDRGTAFI IRFICNDDIY PGAPKFLHQD IDSTRGIRNT YFEFETALAC TPSLVDCQVT 
DPAGNEYDLS ALSMVRKPWT AVDTSAYGKR RHFYLSVCNP LPYIPGCHGI ALGSCMVSED 
NSFNLGVVQI SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY 
VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY YLRVCGKLSS 
DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG LLKMNYTGGD TCHKVYQRST 
TIYFYCDRTT QKPVFLKETS DCSYMFEWRT QYACPPFNVT ECSVQDAAGN SIDLSSLSRY 
SDNWEAVTRT GATEHYLINV CKSLSPHAGT EPCPPEAAVC LLNGSKPVNL GKVRDGPQWT 
DGVTVLQYVD GDLCPDKIRR RSTIIRFTCS DNQVNSRPLF ISAVQDCEYT FSWPTPSACP 
VKSNTHDDCQ VTNPSTGHLF DLSSLSGRAG INASYSEKGL VFMSICEENE NCGPGVGACF 
GQTRISVGKA SKRLSYKDQV LQLVYENGSP CPSLSDLRYK SVISFVCRPE AGPTNRPMLI 
SLDKQTCTLF FSWHTPLACE QATECTVRNG SSIIDLSPLI HRTGGYEAYD ESEDDTSDTT 
PDFYINICQP LNPMHGVPCP AGASVCKVPV DGPPIDIGRV TGPPIFNPVA NEVYLNFESS 
THCLADRYMN YTSLITFHCK RGVSMGTPKL IRTNDCDFVF EWETPIVCPD EVKTQGCAVT 
DEQLLYSFNL TSLSTSTFKV TRDARTYSIG VCTAAAGLGQ EGCKDGGVCL LSGNKGASFG 
RLASMQLDYR HQDEAVILSY VNGDPCPPET DDGEPCVFPF IYKGKSYDEC VLEGRAKLWC 
SKTANYDRDH EWGFCRQTNS YRMSAIIFTC DESEDIGRPQ VFSEDRGCEV TFEWKTKVVC 
PPKKMECKFV QKHKTYDLRL LSSLTGSWDF VHEGNSYFIN LCQRVYKGPL DCSERASICK 
KSATGQVQVL GLVHTQKLEV IDETVIVTYS KGYPCGGNKT ASSVIELTCA KTVGRPAFKR 
FDSVSCTYYF YWYSRAACAV RPQEVTMVNG TLTNPVTGKS FSLGEIYFKL FSASGDMRTN 
GDNYLYEIQL SSITSSSYPA CAGANICQVK PNDQHFSRKV GTSDMTKYYV QDGDLDVVFT 
SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP EFSHETADCQ YLFSWYTSAV CPLGVDFEDE 
SAGPEYKGLS ERSQAVGAVL SLLLVALTGC LLALLLHKKE RRETVINKLT SCCRRSSGVS 
YKYSKVSKEE ETDENETEWL MEEIQVPAPR LGKDGQENGH ITTKAVKAEA LSSLHGDDQD 
SEDEVLTVPE VKVHSGRGAE VESSQPLRNP QRKVLKEREG ERLGLVRGEK ARKGKFRPGQ 
RKPTAPAKLV SFHDDSDEDL LHI

Genular Protein ID: 406136996

Symbol: Q8C6V9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C6V9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 738
Mass: 82198
Checksum: 66F784C5657E0901
Sequence:

DRYMNYTSLI TFHCKRGVSM GTPKLIRTND CDFVFEWETP IVCPDEVKTQ GCAVTDEQLL 
YSFNLTSLST STFKVTRDAR TYSIGVCTAA AGLGQEGCKD GGVCLLSGNK GASFGRLASM 
QLDYRHQDEA VILSYVNGDP CPPETDDGEP CVFPFIYKGK SYDECVLEGR AKLWCSKTAN 
YDRDHEWGFC RQTNSYRMSA IIFTCDESED IGRPQVFSED RGCEVTFEWK TKVVCPPKKM 
ECKFVQKHKT YDLRLLSSLT GSWDFVHEGN SYFINLCQRV YKGPLDCSER ASICKKSATG 
QVQVLGLVHT QKLEVIDETV IVTYSKGYPC GGNKTASSVI ELTCAKTVGR PAFKRFDSVS 
CTYYFYWYSR AACAVRPQEV TMVNGTLTNP VTGKSFSLGE IYFKLFSASG DMRTNGDNYL 
YEIQLSSITS SSYPACAGAN ICQVKPNDQH FSRKVGTSDM TKYYVQDGDL DVVFTSSSKC 
GKDKTKSVSS TIFFHCDPLV KDGIPEFSHE TADCQYLFSW YTSAVCPLGV DFEDESAGPE 
YKGLSERSQA VGAVLSLLLV ALTGCLLALL LHKKERRETV INKLTSCCRR SSGVSYKYSK 
VSKEEETDEN ETEWLMEEIQ VPAPRLGKDG QENGHITTKA VKAEALSSLH GDDQDSEDEV 
LTVPEVKVHS GRGAEVESSQ PLRNPQRKVL KEREGERLGL VRGEKARKGK FRPGQRKPTA 
PAKLVSFHDD SDEDLLHI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Igf2r

Associated with

Other Information

The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization. PubMed ID: 8188212

Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor. PubMed ID: 8194771

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. PubMed ID: 8462104

Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements. PubMed ID: 8584025

Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells. PubMed ID: 1848553

Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes. PubMed ID: 8226743

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073